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Keywords: Placenta
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (8): dev200104.
Published: 22 April 2022
...Laina Freyer; Yvan Lallemand; Pascal Dardenne; Alina Sommer; Anne Biton; Elisa Gomez Perdiguero ABSTRACT Hofbauer cells (HBCs) are tissue macrophages of the placenta thought to be important for fetoplacental vascular development and innate immune protection. The developmental origins of HBCs remain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200115.
Published: 31 March 2022
... promoted proliferation identical to Rocki, indicating an all-encompassing upstream regulation. Morphological differentiation included formation of binucleate cells and infrequent multinucleate syncytia, features we also localize in the in vivo bovine placenta. Collectively, we demonstrate a central role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200013.
Published: 17 February 2022
.... ( 2014 ). The placenta harbors a unique microbiome . Sci. Transl. Med. 6 , 237ra65 . 10.1126/scitranslmed.3008599 Aghaeepour , N. , Ganio , E. A. , Mcilwain , D. , Tsai , A. S. , Tingle , M. , Van Gassen , S. , Gaudilliere , D. K. , Baca , Q. , McNeil , L...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199840.
Published: 12 January 2022
... is known about the processes controlling human CTB progenitor maintenance and differentiation. To address this, we established a single cell RNA sequencing (scRNA-seq) dataset from first trimester placentas to identify cell states important in trophoblast progenitor establishment, renewal...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (1): dev199811.
Published: 4 January 2022
... the importance of ICR1 in the placental production of hormones that promote maternal nutrient allocation to the fetus is unknown. To address this, we used a novel mouse model to selectively delete ICR1 in the endocrine junctional zone (Jz) of the mouse placenta (Jz-ΔICR1). The Jz-ΔICR1 mice exhibit increased...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (20): dev199626.
Published: 19 October 2021
... the uterine surface, these progenitors assume a different fate, becoming cancer-like cells that invade its lining and blood vessels. The latter process physically connects the placenta to the mother and shunts uterine blood to the syncytiotrophoblasts. Isolation of trophoblast subtypes is technically...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (13): dev199561.
Published: 1 July 2021
...Hao Chen; Katherine E. Williams; Elaine Y. Kwan; Mirhan Kapidzic; Kenisha A. Puckett; Rayyan K. Aburajab; Joshua F. Robinson; Susan J. Fisher ABSTRACT During human pregnancy, cytotrophoblasts (CTBs) from the placenta differentiate into specialized subpopulations that play crucial roles in proper...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197673.
Published: 27 April 2021
... of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev187013.
Published: 8 September 2020
...Sara K. Taylor; Sahar Houshdaran; Joshua F. Robinson; Matthew J. Gormley; Elaine Y. Kwan; Mirhan Kapidzic; Birgit Schilling; Linda C. Giudice; Susan J. Fisher ABSTRACT The placenta releases large quantities of extracellular vesicles (EVs) that likely facilitate communication between the embryo...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev190371.
Published: 3 July 2020
... cell mass (ICM). The recombined allele is inherited in the trophoblast lineage, enabling placenta-specific Cre/loxP gene editing. The most common conditional knockout system relies on loxP sites that flank critical exon(s) of the target locus, in combination with Cre recombinase expressed under...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (11): dev186551.
Published: 29 May 2020
... risk for abnormal placentation. Using a mouse model, we investigate how individual procedures contribute to placental defects across development. Assisted reproductive technologies Fetal growth Placenta Preeclampsia sFLT1 Assisted reproductive technologies (ARTs), including in vitro...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev163428.
Published: 27 November 2019
...Margherita Y. Turco; Ashley Moffett ABSTRACT The placenta is essential for normal in utero development in mammals. In humans, defective placental formation underpins common pregnancy disorders such as pre-eclampsia and fetal growth restriction. The great variation in placental types across mammals...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (11): dev172205.
Published: 10 June 2019
... from poor functioning of the placenta. In vivo models of maternal stressors, such as nutrient deficiency, and placental insufficiency often focus on inadequate growth of the fetus and placenta in late gestation. These studies rarely investigate the origins of poor placental formation in early gestation...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (4): dev174037.
Published: 22 February 2019
... placentas result from deregulation of the above events, we collected embryos at E8.5-E9 and carefully observed the structure of the allantois fusing into the chorionic plate. We did not detect any obvious morphological differences in this process between wild-type and Usp22 mutant embryos ( Fig. 2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev162305.
Published: 16 April 2018
...Cheryl Q. E. Lee; Margherita Y. Turco; Lucy Gardner; Benjamin D. Simons; Myriam Hemberger; Ashley Moffett ABSTRACT During pregnancy the trophoblast cells of the placenta are the only fetal cells in direct contact with maternal blood and decidua. Their functions include transport of nutrients...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev156273.
Published: 29 January 2018
... differences in early placental development between mouse and human, but a detailed comparison of placentae in these two species is missing. We set out to compare placentae from both species across gestation, with a focus on trophoblast progenitor markers. We found that CDX2 and ELF5, but not EOMES...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev148932.
Published: 29 January 2018
...Wen-Lin Chang; Ya-Wei Liu; Yan-Li Dang; Xiang-Xiang Jiang; Honglin Xu; Xing Huang; Yan-Ling Wang; Haibin Wang; Cheng Zhu; Li-Qun Xue; Hai-Yan Lin; Wenxiang Meng; Hongmei Wang ABSTRACT Proper differentiation of trophoblast cells in the human placenta is a prerequisite for a successful pregnancy...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4481–4495.
Published: 15 December 2017
... Organogenesis Cell-cell fusion Syncytin Fusexins EFF-1 HAP2 GCS1 AFF-1 Myomaker Myomixer Myomerger Minion Placenta Muscle Virus-cell fusion Tick-borne encephalitis Zika Influenza Dengue viruses SNAREs Hemifusion Pore formation The vast majority of cells are capable of cell division...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (20): 3731–3743.
Published: 15 October 2017
..., suggesting a role in placental development. Here, we evaluate that role. A knock-in reporter for the mouse miR-290 cluster is expressed throughout the embryo until gastrulation, when it becomes specifically expressed in extraembryonic tissues and the germline. In the placenta, expression is limited...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (13): 2469–2479.
Published: 1 July 2017
... gross defects in chorioallantoic branching morphogenesis and placental vascular patterning. Microangiography and 3D imaging revealed patchy perfusion of Egfl7 −/− placentas marked by impeded blood conductance through sites of narrowed vessels. Consistent with poor feto-placental perfusion, Egfl7...
Includes: Supplementary data