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Keywords: Pitx2
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Journal Articles
Journal: Development
Development (2021) 148 (17): dev199265.
Published: 6 September 2021
... in the leftward curvature of the stomach. To elucidate the molecular events that shape this archetypal laterality, we performed transcriptome analyses of the left versus right sides of the developing stomach in frog embryos. Besides the known LR gene pitx2 , the only gene found to be expressed asymmetrically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev186023.
Published: 4 June 2020
... that Pitx2 (the first transcriptional marker for tooth development) controls the embryonic formation and patterning of epithelial signaling centers during incisor development. We demonstrate using Krt14 Cre / Pitx2 flox/flox ( Pitx2 cKO ) and Rosa26 CreERT /Pitx2 flox/flox mice that loss of Pitx2 delays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev180398.
Published: 14 June 2019
...Matthew C. Hill; Zachary A. Kadow; Lele Li; Tien T. Tran; Joshua D. Wythe; James F. Martin; Allon Klein; Barbara Treutlein ABSTRACT The Pitx2 gene encodes a homeobox transcription factor that is required for mammalian development. Disruption of PITX2 expression in humans causes congenital heart...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1477–1483.
Published: 15 April 2017
... tube itself. The left wall of the primitive stomach expands more than the right wall, as the left epithelium becomes more polarized and undergoes radial rearrangement. These asymmetries exist across several species, and are dependent on LR patterning genes, including Foxj1 , Nodal and Pitx2 . Our...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (7): 1572–1579.
Published: 1 April 2014
... Pitx2 Epithalamus Left-right Parapineal Zebrafish The epithalamus is composed of the left and right habenulae, and the pineal complex, which is itself composed of the pineal gland and the parapineal nucleus ( Concha and Wilson, 2001 ). Although the habenulae link the anterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3348–3359.
Published: 15 August 2013
... rise to ameloblasts, which generate enamel, and little is known about the function of microRNAs in this process. Here, we describe the role of a novel Pitx2:miR-200c/141:noggin regulatory pathway in dental epithelial cell differentiation. miR-200c repressed noggin, an antagonist of Bmp signaling. Pitx2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (13): 2807–2821.
Published: 1 July 2011
... for HH4; Fig. 1Ai-Ei for HH5). At HH6, the anterior head mesoderm expressed Pitx2 ( Fig. 1Aii ), the posterior head mesoderm Tbx1 ( Fig. 1Dii ). Twist was also expressed, with elevated levels in the posterior head mesoderm and the developing somites ( Fig. 1Eii ). Overall, expression was more...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3025–3035.
Published: 15 September 2010
... Jag2-mediated Notch signalling and transcription factors and growth factors. Analysis of lineage and differentiation marker genes, such as Pitx1 ( Mitsiadis and Drouin, 2008 ), Pitx2 ( Mitsiadis and Drouin, 2008 ; Mitsiadis et al., 1998b ; Mucchielli et al., 1997 ), Pax9 ( Peters et al., 1998...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (8): 1339–1349.
Published: 15 April 2010
... Shroom3 expression in the epidermis ( Fig. 6C,D ). Similar results were obtained with Pitx2 and Pitx3 ( Fig. 6E-H and data not shown). Moreover, ectopic Pitx expression in the epidermis resulted in ectopic pigment accumulation ( Fig. 6B,F ), a phenotype that is similar to that caused by ectopic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (4): 677–685.
Published: 15 February 2008
... ovary. A possible role for estrogen in this asymmetric ovarian development has been proposed in the chick, but the mechanism underlying this process is largely unknown. Here, we identify the molecular mechanism responsible for this ovarian asymmetry. Asymmetric PITX2 expression in the left presumptive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4199–4208.
Published: 1 December 2007
... for testis differentiation. We find that these L-R differences depend on the L-R asymmetry pathway that controls the situs of organs such as the heart and gut. Moreover, a key determinant of this, Pitx2 , is expressed asymmetrically, such that it is found only in the left gonad in both sexes from the start...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 3015–3025.
Published: 1 August 2006
...Hidetaka Shiratori; Kenta Yashiro; Michael M. Shen; Hiroshi Hamada Pitx2 is expressed in developing visceral organs on the left side and is implicated in left-right (LR) asymmetric organogenesis. The asymmetric expression of Pitx2 is controlled by an intronic enhancer (ASE) that contains multiple...
Journal Articles
Journal: Development
Development (2006) 133 (8): 1565–1573.
Published: 15 April 2006
... goal is to understand the molecular pathogenesis of cardiovascular defects in this syndrome. However, the molecular pathways of Tbx1 are still largely unexplored. Here, we show that Tbx1 is co-expressed with the bicoid -like homeodomain transcription factor Pitx2 in secondary heart field cells...
Journal Articles
Journal: Development
Development (2003) 130 (1): 45–55.
Published: 1 January 2003
...Alexandre Marcil; Émilie Dumontier; Michel Chamberland; Sally A. Camper; Jacques Drouin Two closely related homeobox transcription factors, Pitx1 and Pitx2, have been implicated in patterning of lateral plate mesoderm derivatives: Pitx1 for specification of hindlimb identity and Pitx2...
Journal Articles
Journal: Development
Development (2002) 129 (14): 3421–3429.
Published: 15 July 2002
... and paraxial mesoderm and observed a strong upregulation of Nodal and its target genes Pitx2 and Nkx3.2 . In addition Cfc , the Nodal type II receptor ActrIIa and Snr were found to depend on BMP signaling for their expression. Comparison of the expression domains of Nodal , Bmp2 , Car and Cfc revealed co...
Journal Articles
Journal: Development
Development (2002) 129 (14): 3431–3440.
Published: 15 July 2002
... that exogenous application of BMP to the right LPM rapidly and consistently induced Nodal expression and subsequently that of Pitx2 . Increased BMP signaling in the left LPM also upregulated the normal Nodal and Pitx2 expression. Car , Snail and Cfc expression in the LPM were also positively...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (22): 4787–4795.
Published: 15 November 2000
... upstream of asymmetric nodal related 1 ( Xnr1 ) and Pitx2 expression in L-R patterning. We report here that Zic3 carries the left-sided signal from the initial activin-like signal to determinative factors such as Pitx2 . Overexpression of Zic3 on the right side of the embryo altered the orientation...