... primordium were provided by the axons of a transient population of unipolar neurons, which they called `pioneer' neurons( Whitlock and Westerfield,1998 ). robo2 is transiently expressed in the olfactory placode and its temporal expression parallels the axon outgrowth of unipolar neurons ( Fig. 1...

...-mail: saizawa@cdb.riken.go.jp ) 18 4 2002 © 2002. 2002 Neocortex Cortical lamination Radial cell migration Tangential cell migration Emx1 Emx2 Cajal-Retzius cells Subplate neurons Pioneer neurons Interneurons Ganglionic eminence Mouse The mammalian cortex is the most...

...A. Hidalgo; A. H. Brand ABSTRACT Although pioneer neurons are the first to delineate the axon pathways, it is uncertain whether they have unique pathfinding abilities. As a first step in defining the role of pioneer neurons in the Drosophila embryonic CNS, we describe the temporal profile...

... the final stage of the work. L. G-A. was an EMBO Postdoctoral Fellow and HHMI Fellow. R. D. F. is a Senior Research Associate and C. S. G. is an Investigator with the Howard Hughes Medical Institute. REFERENCES Anderson , H. and Tucker , R. P. ( 1988 ). Pioneer neurones use basal lamina...

... for assisting axon guidance over long distances is to use pioneer neurons. Pioneer neurons arise early in embryogenesis and grow an axon to establish a pathway to the CNS whilst the distances to be navigated are still short and less complex. Thus, later developing axons can find the CNS by following the route...

.... ( 1989 ). Transient pioneer neurons are essential for formation of an embryonic peripheral nerve . Science 245 , 982 – 984 . Kroger , S. and Schwarz , U. ( 1990 ). The avian tectobulbar tract: Development, explant culture, and effects of antibodies on the pattern of neurite...

... within the leg discs. 29 09 1989 © 1989 by Company of Biologists 1989 Drosophila selective labelling pioneer neurons imaginal discs In holometabolous insects, the imaginal appendages develop from nests of undifferentiated cells, the imaginal discs. Growth...