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Keywords: Pioneer factor
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Journal Articles
Journal: Development
Development (2022) 149 (14): dev200547.
Published: 21 July 2022
... as in controlling cell proliferation, lineage decisions and differentiation. Recent studies have revealed that the ability of SOX2 to regulate these stem cell features involves its function as a pioneer factor, with the capacity to target nucleosomal DNA, modulate chromatin accessibility and prepare silent genes...
Journal Articles
Journal: Development
Development (2020) 147 (5): dev185009.
Published: 11 March 2020
... have the unique property of binding closed chromatin and facilitating the establishment of these accessible regions. Nonetheless, much of how pioneer transcription factors coordinate changes in chromatin accessibility during development remains unknown. To determine whether pioneer-factor function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (6): dev163162.
Published: 20 March 2018
... pathway terms for genes associated with newly primed enhancers in Ngn3-high cells. Of the 54,514 primed enhancers identified in Ngn3-high cells, 57.9% were unmarked in the Ngn3-low cells ( Fig. 3 C). The selection of new enhancer loci during cell fate transitions may be guided by ‘pioneerfactors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2281–2291.
Published: 1 July 2016
... to maintain a proper balance between self-renewal and differentiation towards neuronal or glial lineages. TALE-homeodomain protein Adult neurogenesis Subventricular zone Cell fate specification Doublecortin Pioneer factor Highlighted article: The TALE-homeodomain protein PBX1 promotes...
Includes: Supplementary data