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Keywords: Photoreceptor
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Journal Articles
Journal: Development
Development (2021) 148 (23): dev199551.
Published: 8 December 2021
... synapse of the visual system between photoreceptors and bipolar cells in the outer plexiform layer (OPL) of the human retina is crucial for visual processing but poorly understood. By studying the maturation state and spatial organization of photoreceptors, depolarizing bipolar cells and horizontal cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev198549.
Published: 30 April 2021
... of daughter cells, such as a cone photoreceptor and a horizontal cell (HC). We used genome-wide assays of chromatin structure to compare the profiles of a restricted cone/HC RPC and those of other RPCs in chicks. These data nominated regions of regulatory activity, which were tested in tissue, leading...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev184432.
Published: 5 February 2020
... photoreceptor CREs from wild-type and mutant mouse retinas, defined by presence or absence, respectively, of the rod-specific transcription factor (TF) Nrl . Nrl -dependent ncRNA expression strongly correlated with epigenetic profiles of rod and cone photoreceptors, identified thousands of candidate rod...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (3): dev158246.
Published: 5 February 2018
... behavior. Sidekick is required in photoreceptors, but not in their target lamina neurons, to promote the alignment of lamina neurons into columns and subsequent sorting of photoreceptor axons into synaptic modules based on their precise spatial orientation. Sidekick is also localized to the dendrites...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (5): 844–855.
Published: 1 March 2017
... Proventriculus (Dve) at distinct cell type-specific levels is required for terminal differentiation of color- and motion-detecting photoreceptors. Here, we find that the activities of two cis- regulatory enhancers are coordinated to drive dve expression in the fly eye. Three transcription factors act...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4701–4712.
Published: 15 December 2016
... Photoreceptor Notch signalling Atonal homolog 7 Fibroblast growth factor 3 Neurogenin 2 Primate retinas are characterised by a specialised central region, the macula, while their periphery resembles that of other mammals. The macula is subdivided into different areas, including the fovea...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2389–2397.
Published: 1 July 2016
... specification is incompletely understood. In this article, we identify the insulator protein BEAF-32 as a regulator of Hippo pathway activity in Drosophila photoreceptor differentiation. Though morphologically uniform, the fly eye is composed of two subtypes of R8 photoreceptor neurons defined by expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1571–1584.
Published: 1 May 2016
... cell type. Of these, rod and cone photoreceptors represent the functional unit of light detection and phototransduction and are frequently affected in retinal degenerative diseases. During mouse development, the Polycomb group protein Bmi1 is expressed in immature retinal progenitors and differentiated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (8): 1413–1423.
Published: 15 April 2016
... to differentiate into photoreceptors. We show that photoreceptor cell identity in Drosophila is critically regulated by the transcription factor Glass, which is primarily expressed in photoreceptors and whose role in this process was previously unknown. Glass is both required and sufficient for the expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3263–3273.
Published: 1 October 2015
...Joseph A. Brzezinski; Thomas A. Reh Photoreceptors – the light-sensitive cells in the vertebrate retina – have been extremely well-characterized with regards to their biochemistry, cell biology and physiology. They therefore provide an excellent model for exploring the factors and mechanisms...
Journal Articles
Journal: Development
Development (2015) 142 (14): 2487–2498.
Published: 15 July 2015
...Reut Ohana; Benjamin Weiman-Kelman; Shaul Raviv; Ernst R. Tamm; Metsada Pasmanik-Chor; Ariel Rinon; Dvir Netanely; Ron Shamir; Arie S. Solomon; Ruth Ashery-Padan Dysfunction of the retinal pigmented epithelium (RPE) results in degeneration of photoreceptors and vision loss and is correlated...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: Primer Series
Development (2013) 140 (3): 493–503.
Published: 1 February 2013
... 2013. Published by The Company of Biologists Ltd 2013 Hippo pathway Cell identity maintenance Olfactory receptor Opsin Photoreceptor Sensory Multicellular organisms are able to perceive and discriminate a broad range of environmental stimuli within a number of sensory modalities...
Journal Articles
Journal: Development
Development (2012) 139 (16): 2891–2896.
Published: 15 August 2012
... null mutants of Drosophila Patj ( dPatj ). Our data show conclusively that dPatj only plays supporting and non-essential roles in regulating apical-basal polarity, although such a supporting role may become crucial in cells such as photoreceptors that undergo complex cellular morphogenesis. In addition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (22): 4899–4909.
Published: 15 November 2011
... of a subset of photoreceptor (R cell) axons to innervate appropriate target columns. In particular, single-cell mosaic analyses demonstrate that R cell growth cones lacking Gek function grow to the appropriate ganglion, but frequently fail to innervate the correct target column. Further studies reveal that R...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2325–2336.
Published: 1 June 2011
...Jimmy de Melo; Guang-Hua Peng; Shiming Chen; Seth Blackshaw The mammalian retina is a tractable model system for analyzing transcriptional networks that guide neural development. Spalt family zinc-finger transcription factors play a crucial role in photoreceptor specification in Drosophila...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2895–2904.
Published: 1 September 2010
...Monalisa Mishra; Ashwini Oke; Cindy Lebel; Elizabeth C. McDonald; Zachary Plummer; Tiffany A. Cook; Andrew C. Zelhof The function and integrity of photoreceptor cells are dependent upon the creation and maintenance of specialized apical structures: membrane discs/outer segments in vertebrates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (4): 619–629.
Published: 15 February 2010
...Joseph A. Brzezinski, IV; Deepak A. Lamba; Thomas A. Reh Photoreceptors, rods and cones are the most abundant cell type in the mammalian retina. However, the molecules that control their development are not fully understood. In studies of photoreceptor fate determination, we found that Blimp1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (2): 273–281.
Published: 15 January 2010
... these interactions is required for its ability to suppress the eye fate. We show that two LIM-homeodomain proteins, Arrowhead and Lim1, are expressed in the region of the eye-antennal disc affected in Chip mutants, and that both require Chip for their ability to suppress photoreceptor differentiation when...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 2955–2964.
Published: 1 September 2009
... of the dynactin complex. Loss of ako function results in a degeneration of photoreceptors and mechanosensory hair cells. Additionally, mutant Müller cells lose apical processes and their perikarya translocate rapidly towards the vitreal surface of the retina. This is accompanied by the accumulation of the apical...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 4071–4079.
Published: 15 December 2008
... selection of single founder photoreceptors (R8s) for each unit eye or ommatidium. R8 selection requires mechanisms that restrict R8 potential to a single cell from within a group of cells expressing the proneural gene atonal ( ato ). One model of R8 selection suggests that R8 precursors are selected from...
Includes: Supplementary data