... signaling through phosphorylation of Dishevelled. However, besides general protein phosphatases 1 and 2 (PP1 and PP2), no specific protein phosphatases have been identified. Here, we report on the identification and functional characterization of the protein phosphatase Pgam5 in vitro and in vivo in Xenopus...

... the molecular pathways active during epidermal barrier formation. Akt signaling increased as the barrier wave crossed epidermis and Jun was transiently dephosphorylated. Inhibitor experiments on embryonic explants showed that the dephosphorylation of Jun was dependent on both Akt and protein phosphatase 2A(Pp2a...

...Donald G. McEwen; Mark Peifer MAPK phosphatases (MKPs) are important negative regulators of MAPKs in vivo, but ascertaining the role of specific MKPs is hindered by functional redundancy in vertebrates. Thus, we characterized MKP function by examining the function of Puckered (Puc), the sole...

...Robert J. Harrington; Michael J. Gutch; Michael O. Hengartner; Nicholas K. Tonks; Andrew D. Chisholm Receptor-like protein-tyrosine phosphatases (RPTPs) form a diverse family of cell surface molecules whose functions remain poorly understood. The LAR subfamily of RPTPs has been implicated in axon...

... revealed a complete block of meiosis in males and severe meiotic defects in females. * Author for correspondence 06 07 1992 © 1992 by Company of Biologists 1992 cdc25 Drosophila phosphatase meiosis string twine The cdc25 gene was initially identified...