...Judith A. Blake; Melanie R. Ziman Pax genes encode a family of transcription factors that orchestrate complex processes of lineage determination in the developing embryo. Their key role is to specify and maintain progenitor cells through use of complex molecular mechanisms such as alternate RNA...

... binding sites; box 3 is a HMG-binding site. (Bottom) The tree shows the phylogenetic relationship of these three species. * Author for correspondence (e-mail: ralf.sommer@tuebingen.mpg.de ) 22 6 2007 © 2007. 2007 P. pacificus Vulva development C. elegans Pax genes lin...

... of the scapular blade, whereas, by contrast, the scapular head derives from the somatopleure. It also became clear that signals from the surface ectoderm provide essential instructive signals( Ehehalt et al., 2004 ). Aristaless-like genes Gli3 Mouse mutants Pax genes Scapula Skeletogenesis Tbx15...

.... * Author for correspondence (e-mail: nazpiazu@cbm.uam.es ) 3 6 2003 © 2003. 2003 eyg toe Thorax Pax genes Drosophila In Drosophila , much is known about genetic subdivisions of the body. An early and fundamental one is the segregation of anterior (A) and posterior (P...

...Lei Xue; Markus Noll The Drosophila Pax gene paired encodes a transcription factor that is required for the activation of segment-polarity genes and proper segmentation of the larval cuticle, postembryonic viability and male fertility. We show that paired executes a dual role in the development...

... and growth alterations in Drosophila wings . EMBO J . 13 , 4459 – 4468 . 10.1002/j.1460-2075.1994.tb06768.x Dahl , E. , Koseki , H. and Balling , R. ( 1997 ). Pax genes and organogenesis . BioEssays 19 , 755 – 765 . 10.1002/bies.950190905 FlyBase . ( 1998...

... 1999 © 1999 by Company of Biologists 1999 Neurogenesis Forebrain Optic stalk fgf8 pax genes acerebellar noisthmus Zebrafish Danio rerio During early vertebrate development, the nervous system becomes subdivided into discrete regions along its anterior- posterior...

... integrator of midbrain-hindbrain boundary development. * Author for correspondence (e-mail: brand@sun0.urz.uni-heidelberg.de ) © 1998 by Company of Biologists 1998 Midbrain-hindbrain organizer Neurogenesis Regionalization Neural patterning Splicing Pax genes no isthmus Zebrafish...

... ). The ventral and posterior expression of the zebrafish homeobox gene eve1 is perturbed in dorsalized and mutant embryos . Development 119 , 1261 – 1275 . 10.1242/dev.119.4.1261 Joyner , A. L. ( 1996 ). Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development . TIG 12 , 15...

...@genetics.washington.edu ) † Current address: Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030-3498, USA 06 07 1997 © 1997 by Company of Biologists 1997 Caenorhabditis elegans PAX genes paired domain cell lineage pattern formation An important question...

... 04 1996 The first vertebrate members of the pax gene family were isolated using a ‘paired-box’-containing probe from the Drosophila paired locus (reviewed by Noll, 1993 ; Chalepakis et al., 1993 ). The Drosophila paired gene cooperates with wingless, hedgehog and engrailed...

... genes BMP proteins somitic differentiation neural tube polarisation vertebral cartilage formation Pax genes In a previous study carried out on the avian embryo, we have shown that the vertebra is composed of two regions, the development of which obeys distinct regulatory mechanisms...

.... , Tremblay , P. and Gruss , P. ( 1993 ). Pax : gene regulators in the developing nervous system. [Review] . J. Neurobiol . 24 , 1367 – 84 . 10.1002/neu.480241009 Czerny , T. , Schaffner , G. and Busslinger , M. ( 1993 ). DNA sequence recognition by Pax proteins...

... , 873 – 884 . 10.1016/0092-8674(91)90434-Z Chalepakis , G. , Stoykova , A. , Wijnholds , J. , Tremblay , P. and Gruss , P. ( 1993 ). Pax: gene regulators in the developing nervous system . J. Neurobiol . 24 , 1367 – 1384 . 10.1002/neu.480241009 Chan , S. K...

...Patrick Tremblay; Fabienne Pituello; Peter Gruss ABSTRACT The Pax genes containing a complete paired-type homeobox are expressed in restricted dorsoventral domains of the undifferentiated neuroepithelium. Their expression respond to signals that pattern the neural tube and which emanate from...

... dorsal neural tube, surface ectoderm and dorsomedial somite regions in specifying epaxial musculature are discussed. * Author for correspondence at address 1 18 09 1995 © 1996 by Company of Biologists 1996 neural tube Pax genes myogenic factors somite hypaxial muscle...

...Martyn D. Goulding; Andrew Lumsden; Peter Gruss ABSTRACT Members of the paired box (Pax) gene family are expressed in discrete regions of the developing central nervous system, suggesting a role in neural patterning. In this study, we describe the isolation of the chicken homologues of Pax-3...