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Keywords: Parkinson's disease
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Journal Articles
Journal: Development
Development dev.200504.
Published: 28 October 2022
... differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting...
Journal Articles
Journal: Development
Development (2020) 147 (18): dev192567.
Published: 17 September 2020
... by The Company of Biologists Ltd 2020 Summary: This short Spotlight summarizes the current state of pre-clinical and clinical research using pluripotent stem cells for regenerative therapy, and the influence of developmental biology-inspired approaches. Cardiomyopathy Diabetes Parkinson's disease...
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156117.
Published: 8 January 2018
...Malin Parmar ABSTRACT Treating neurodegenerative diseases with cell transplantation has been within reach since the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain were transplanted to individuals with Parkinson's disease. However, the use of fetal tissue...
Journal Articles
Journal: Development
Development (2015) 142 (14): 2392–2396.
Published: 15 July 2015
... that the retromer complex is involved in specific developmental processes. Moreover, a number of recent studies implicate aberrant retromer function in photoreceptor degeneration, Alzheimer's disease and Parkinson's disease. Here, and in the accompanying poster, we provide an overview of the molecular and cellular...
Journal Articles
Journal: Development
Development (2015) 142 (11): 1918–1936.
Published: 1 June 2015
..., such as Parkinson's disease (PD), might be facilitated by a better understanding of how these neurons are specified, differentiated and maintained in vivo . This knowledge might help to instruct efforts to generate mDA neurons in vitro , which holds promise not only for cell replacement therapy, but also for disease...
Journal Articles
Journal: Development
Development (2012) 139 (17): 3136–3141.
Published: 1 September 2012
... Competing interests statement The authors declare no competing financial interests. 11 6 2012 © 2012. Midbrain Neuronal migration Parkinson’s disease Neuronal migration is a fundamental process in the development of the central nervous system because neurons eventually...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2447–2451.
Published: 1 July 2012
... and maturation of Nurr1-induced DA neurons. Mature DA neurons were generated by manipulating Nurr1 expression patterns to resemble those in the developing midbrain. 24 4 2012 © 2012. Parkinson’s disease Dopamine neurons Nurr1 Neuronal maturation Doxycycline inducible expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 531–540.
Published: 15 February 2009
...Frank M. J. Jacobs; Susan van Erp; Annemarie J. A. van der Linden; Lars von Oerthel; J. Peter H. Burbach; Marten P. Smidt In recent years, the meso-diencephalic dopaminergic (mdDA) neurons have been extensively studied for their association with Parkinson's disease. Thus far, specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3459–3470.
Published: 15 October 2008
...Daniela Omodei; Dario Acampora; Pietro Mancuso; Nilima Prakash; Luca Giovanni Di Giovannantonio; Wolfgang Wurst; Antonio Simeone Meso-diencephalic dopaminergic (mdDA) neurons control voluntary movement,cognition and the reward response, and their degeneration is associated with Parkinson's disease...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3213–3225.
Published: 1 September 2007
... issues for realizing safe and efficient cell transplantation therapies for Parkinson's disease. Although recent studies have identified the factors that regulate mesDA neuron development, the mechanisms underlying mesDA neuron specification are not fully understood. Recently, it has been suggested...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (15): 2881–2887.
Published: 1 August 2007
...Clare L. Parish; Anna Beljajeva; Ernest Arenas; András Simon Death and lack of functional regeneration of midbrain dopaminergic (DA)neurons, decreased DA input in the target striatum and movement anomalies characterise Parkinson's disease (PD). There is currently no cure for PD. One way to promote...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (14): 2673–2684.
Published: 15 July 2007
...Frank M. J. Jacobs; Simone M. Smits; Cornelle W. Noorlander; Lars von Oerthel; Annemarie J. A. van der Linden; J. Peter H. Burbach; Marten P. Smidt Selective neuronal loss in the substantia nigra (SNc), as described for Parkinson's disease (PD) in humans and for Pitx3 deficiency in mice,highlights...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (3): 495–505.
Published: 1 February 2006
... Sox2 Nurr1 Stem cells Parkinson's disease During the initial phases of nervous system development, progenitor cells in the neural tube proliferate and divide symmetrically to give rise to identical multipotent neuroepithelial cells. These progenitors subsequently divide asymmetrically...
Journal Articles
Journal: Development
Development (2006) 133 (3): 507–516.
Published: 1 February 2006
... abnormalities in the ventral midbrain. † Author for correspondence (e-mail: anders.bjorklund@med.lu.se ) * These authors contributed equally to this work 25 11 2005 ©2006. 2006 Parkinson's disease Proneural genes Differentiation Midbrain Tyrosine hydroxylase Mouse...