... state of myoblasts, suppressing their differentiation, while a further branchial arch derived signal, namely Bmp7, is an overall negative regulator of head myogenesis. Bmp7 beads ( Fig. 9P-W , n =23) downregulated the lateral rectus markers (shown for Paraxis , Fig. 9P,Q ,open arrowhead), but also...

... the Wnt6 signal. Intracellularly, this leads to the activation of theβ-catenin/LEF1-dependent pathway. Finally, we demonstrate that the bHLH transcription factor paraxis , which was previously shown to be a major player in the epithelial organisation of somites, is a target of theβ-catenin signal. We...

... and differentiation of graft-derived cells were assayed using QCPN and QH1 antibodies to identify all quail cells and quail endothelial cells, respectively. Chimeric embryos were assayed for expression of myf5, myod, paraxis and lbx1 , and the synthesis of myosin heavy chain (MyHC), between 1 and 6 days later (stages...

...Roy C. Mootoosamy; Susanne Dietrich Most head muscles arise from the pre-otic axial and paraxial head mesoderm. This tissue does not form somites, yet expresses the somitic markers Lbx1 , Pax7 and Paraxis in a regionalised fashion. The domain set aside by these markers provides the lateral rectus...

... the dorsomedial and dorsolateral lips of the dermomyotome and entry into the myotome or dispersal into the periphery. Paraxis is a developmentally regulated transcription factor that is required to direct and maintain the epithelial characteristic of the dermomyotome. Therefore, we hypothesized that Paraxis acts...