... ). The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C . Dev. Cell   3 , 183 - 194 . 10.1016/S1534-5807(02)00218-6 Hall , B. K. and Miyake , T. ( 1992 ). The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis...

...Minoti Hiremath; Pamela Dann; Jennifer Fischer; Daniela Butterworth; Kata Boras-Granic; Julie Hens; Joshua Van Houten; Wei Shi; John Wysolmerski Parathyroid hormone-related protein (PTHrP) regulates cell fate and specifies the mammary mesenchyme during embryonic development. Loss of PTHrP or its...

...) and PTHrP signaling play crucial roles in regulating the onset of chondrocyte hypertrophy by forming a negative feedback loop, in which Ihh signaling regulates chondrocyte hypertrophy by controlling PTHrP expression. To understand whether there is a PTHrP -independent role of Ihh signaling in regulating...

...Sylvain Provot; Hervé Kempf; L. Charles Murtaugh; Ung-il Chung; Dae-Won Kim; Jay Chyung; Henry M. Kronenberg; Andrew B. Lassar Parathyroid hormone-related protein (PTHrP) is essential to maintain a pool of dividing, immature chondrocytes in the growth plate of long bones. In chick and mouse...

... column-forming proliferating cells (columnar chondrocytes), stop dividing and finally differentiate into hypertrophic cells. Indian hedgehog (Ihh), which is predominantly expressed in prehypertrophic cells, stimulates expression of parathyroid hormone (PTH)-related peptide (PTHrP) which negatively...

... peptide (PTHrP) has been described in which hypertrophic differentiation is limited by a signal secreted from chondrocytes as they become committed to hypertrophy. In this negative-feedback loop, Ihh inhibits hypertrophic differentiation by regulating the expression of Pthrp , which in turn acts directly...

...Eleonora Minina; Hans Markus Wenzel; Conny Kreschel; Seth Karp; William Gaffield; Andrew P. McMahon; Andrea Vortkamp During endochondral ossification, two secreted signals, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP), have been shown to form a negative feedback loop...

...John Foley; Pamela Dann; James Hong; Jason Cosgrove; Barbara Dreyer; David Rimm; Maureen E. Dunbar; William Philbrick; John J. Wysolmerski Prior reports have demonstrated that both parathyroid hormone-related protein (PTHrP) and the type I PTH/PTHrP receptor are necessary for the proper development...