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Keywords: PTEN
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Journal Articles
Journal: Development
Development (2016) 143 (6): 1005–1015.
Published: 15 March 2016
... upregulates phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (PTEN) expression to activate FoxO, thereby promoting proteolysis during molting in the lepidopteran insect Helicoverpa armigera . FoxO expression is increased during molting and metamorphosis. The knockdown of FoxO in fifth instar larvae...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3752–3763.
Published: 15 October 2012
... and PTEN control blood progenitor proliferation through a common TOR- and 4EBP-dependent pathway. Tsc2 or Pten deficiency in progenitors increases TOR signaling and causes LG overgrowth by increasing the number of actively dividing cells that accumulate high levels of phosphorylated (p) 4EBP during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3422–3431.
Published: 15 September 2012
... they differentiate into interneurons. We found that the PI3K-Akt-mTorc1 pathway is selectively inactivated in migrating neuroblasts in the subventricular zone and rostral migratory stream, and activated when these cells reach the olfactory bulb. Postnatal deletion of Pten caused aberrant activation of the PI3K-Akt...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (23): 5257–5267.
Published: 1 December 2011
... is the lipid phosphatase DAF-18/PTEN, which can modulate PI3K pathway activity during neurodevelopment. Here, we identify a novel role for DAF-18 in promoting neurite outgrowth during development in Caenorhabditis elegans . We find that DAF-18 modulates the PI3K signaling pathway to activate DAF-16/FOXO...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 3011–3020.
Published: 15 July 2011
... of the Nap1/WAVE complex to promote migration of the nascent mesoderm. In addition to migration phenotypes, Rac1 Δ epi cells fail to adhere to matrix, which leads to extensive cell death. Cell death is largely rescued in Rac1 Δ epi mutants that are heterozygous for a null mutation in Pten , providing evidence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1433–1444.
Published: 1 April 2011
...Anyonya R. Guntur; Martina I. Reinhold; Joe Cuellar, Jr; Michael C. Naski Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a direct antagonist of phosphatidylinositol 3 kinase. Pten is a well recognized tumor suppressor and is one of the most commonly mutated genes in human...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 825–833.
Published: 1 March 2010
... to be a downstream target of Alk5 in vivo and in vitro. Loss of Alk5 -mediated signaling also stimulated Pten gene expression and inhibited ERK phosphorylation in vivo. Using lung epithelial cells, we show that Alk5 -regulated Hes1 expression is stimulated through Pten and the MEK/ERK and PI3K/AKT pathways. Thus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (4): 631–640.
Published: 15 February 2010
... of distal bowel aganglionosis induced by vitamin A deficiency in Rbp4 –/– animals. Furthermore, RA reduces phosphatase and tensin homolog (Pten) accumulation in migrating cells, whereas Pten overexpression slows ENS precursor migration. Collectively, these data support the hypothesis that vitamin...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (23): 4731–4735.
Published: 1 December 2006
... signalling antagonist PTEN, which stimulates cell growth in most developing tissues, produces a very different phenotype in nurse cells, inducing formation of highly enlarged lipid droplets. Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 611–619.
Published: 15 February 2006
... activity also triggers developmental quiescence independent of the insulin-like pathway. Our data suggest that these two signalling pathways converge on the C. elegans PTEN orthologue to coordinate germline proliferation with somatic development during dauer formation, via the regulation of AMPK and its...
Journal Articles
Journal: Development
Development (2005) 132 (14): 3281–3291.
Published: 15 July 2005
... as a mechanism for abnormal laminar formation, the role of radial glia, which provide the environmental cues, in modulating neuronal migration is less clear. We provide evidence that loss of PTEN in Bergmann glia leads to premature differentiation of this crucial cell population and subsequently to extensive...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (17): 4103–4109.
Published: 1 September 2002
... present biochemical and genetic evidence that loss of the homolog of the tumor suppressor gene, Pten , results in increased PtdIns P 3 levels and that these increased levels are sufficient to compensate for the complete loss of the Insulin/insulin-like growth factor receptor function. This reduction...
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (5): 791–800.
Published: 1 March 2001
... pathway in differentiation but it is essential for normal growth. Loss of Lilli function causes an autonomous reduction in cell size and partially suppresses the increased growth associated with loss of PTEN function. These results suggest that Lilli acts in parallel with the Ras/MAPK and the PI3K/PKB...