... provided that the original work is properly attributed. Highlighted Article: YAP, an intracellular mediator of the Hippo signaling pathway, establishes epiblast competency for germ cell differentiation through activation of the WNT pathway. EpiSCs PGCs Hippo pathway Pluripotent stem...

...Amanda M. Butler; Dawn A. Owens; Lingyu Wang; Mary Lou King ABSTRACT Xenopus primordial germ cells (PGCs) are determined by the presence of maternally derived germ plasm. Germ plasm components both protect PGCs from somatic differentiation and begin a unique gene expression program. Segregation...

... of maternal vegetally localized mRNAs show that sox7 plays a novel and important role in primordial germ cell (PGC) development and that ephrinB1 ( efnb1 ) is required for proper PGC migration. We propose potential pathways operating at the vegetal pole that highlight where future investigations might be most...

...Yasuhisa Matsui; Asuka Takehara; Yuko Tokitake; Makiko Ikeda; Yuka Obara; Yuiko Morita-Fujimura; Tohru Kimura; Toru Nakano Primordial germ cells (PGCs) are undifferentiated germ cells in embryos, the fate of which is to become gametes; however, mouse PGCs can easily be reprogrammed into pluripotent...

... of epimutations. Notably, primordial germ cells (PGCs) erase genome-wide DNA methylation and H3K9 dimethylation marks in a stepwise manner during migration and gonadal periods. In this study, we profiled DNA and histone methylation on transposable elements during PGC development, and examined the role of DNA...

...Fangfang Lai; Amar Singh; Mary Lou King Nanos is expressed in multipotent cells, stem cells and primordial germ cells (PGCs) of organisms as diverse as jellyfish and humans. It functions together with Pumilio to translationally repress targeted mRNAs. Here we show by loss-of-function experiments...

... to this work 29 5 2003 © 2003. 2003 PGCs SDF1 CXCR4 Chemokine Migration Mouse The gametes of many species arise from a small group of founder cells, the primordial germ cells. These are set aside early in development, in different regions of the embryo in different species...

...Kohji Ikenishi; Yoshinari Tsuzaki To determine whether the location of ‘germ plasm’-bearing cells [presumptive primordial germ cells (pPGCs)] is crucial for their differentiation into PGCs in Xenopus , [ 3 H]thymidine-labelled pPGCs were implanted into the anterior or posterior halves...

...Yasuko Akita; Masami Wakahara ABSTRACT Correlation of the number of primordial germ cells (PGCs) at stage 47 with the amount of germ plasm at the 8-cell stage and with the number of the germ-plasm-containing cells (GPCCs) was analysed using two different laboratory-raised colonies of Xenopus laevis...