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Keywords: PDGF
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (13): 2456–2468.
Published: 1 July 2017
...-cadherins during epithelial-to-mesenchymal transition (EMT). However, the mechanism that controls the upregulation of N-cadherin remains unknown. Here, we show that platelet-derived growth factor receptor alpha (PDGFRα) and its ligand platelet-derived growth factor A (PDGF-A) are co-expressed in migrating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3043–3051.
Published: 15 September 2008
... migration, and that platelet-derived growth factor (Pdgf)appears to act as a guidance cue in this process. However, the mechanisms underlying this process at the individual cell level remain poorly understood. We have identified miles apart ( mil ) as a suppressor of defective anterior migration...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (10): 1863–1874.
Published: 15 May 2008
... interactions between the neural tube and adjacent ectoderm. This induction triggers expression of Pax3, ingression of placode cells and their differentiation into neurons. However, the molecular nature of the underlying signals remains unknown. Here, we investigate the role of PDGF signaling in ophthalmic...
Journal Articles
Journal: Development
Development (2008) 135 (4): 637–646.
Published: 15 February 2008
... characteristic oligodendroglial markers. Aberrant expression of astrocytic and neuronal markers was not observed. Strikingly, we failed to detect PDGF receptor α expression in the mutant oligodendrocyte precursors, arguing that PDGF receptor α is under transcriptional control of Sox9 and Sox10. Altered PDGF...
Journal Articles
Journal: Development
Development (2008) 135 (3): 589–598.
Published: 1 February 2008
... of spina bifida in a PDGFRα mutant background. In addition to vertebral defects, mislocalization of oligodendrocytes and melanocytes hinted that loss of PI3K activation downstream of PDGFRα may result in aberrant cell migration. Although stimulation of PDGF receptors can induce cytoskeletal rearrangements...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (14): 2579–2591.
Published: 15 July 2007
... 5)] or that of smooth muscle cell marker (SMA), indicating that PDGF-induced connective tissue is not highly vascularized and does not contain smooth muscle cells (data not shown). Fig. 6. Blocking vessel formation leads to muscle fusion. ( A-D )Dorsal views of wings from E8 chick embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (11): 2727–2736.
Published: 1 June 2004
... PDGF Gastrulation Cell migration The migration of mesodermal cells away from their site of internalization is a conserved feature of vertebrate gastrulation, although the importance of this process on the mechanics of gastrulation may differ between taxonomic groups ( Winklbauer, 1994...
Journal Articles
Journal: Development
Development (2004) 131 (9): 1939–1948.
Published: 1 May 2004
...Dalia Rosin; Eyal Schejter; Talila Volk; Ben-Zion Shilo Epithelial tissue functions depend largely on a polarized organization of the individual cells. We examined the roles of the Drosophila PDGF/VEGF receptor (PVR) in polarized epithelial cells, with specific emphasis on the wing disc epithelium...
Journal Articles
Journal: Development
Development (2003) 130 (15): 3469–3478.
Published: 1 August 2003
... PDGF VEGF PVF Ecdysone Border cells Cell migration Drosophila The conversion of stationary, epithelial cells to migratory, invasive cells is an important feature of embryonic development and tumor metastasis. The border cells of the Drosophila ovary have emerged as a useful model...
Journal Articles
Journal: Development
Development (2003) 130 (2): 355–367.
Published: 15 January 2003
... of vascular defects around E11.5 due to haemorrhage and vascular integrity defects. Vascular supporting cells did not develop appropriately. C3G-deficient fibroblasts responded to PDGF-BB abnormally, exhibited cell adhesion defects and lacked paxillin and integrin-β1-positive cell adhesions. In contrast...