...Yasuhito Yahara; Tuyet Nguyen; Koji Ishikawa; Katsuhiko Kamei; Benjamin A. Alman ABSTRACT The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells. Osteoclasts are multinucleated monocyte...

...Joana Caetano-Lopes; Katrin Henke; Katia Urso; Jeffrey Duryea; Julia F. Charles; Matthew L. Warman; Matthew P. Harris ABSTRACT Evolution is replete with reuse of genes in different contexts, leading to multifunctional roles of signaling factors during development. Here, we explore osteoclast...

... as autocrine signals that promote the survival of bone cells but also stimulate angiogenesis in a paracrine fashion. MMPs are secreted from osteoclasts (Osc) and vascular endothelial cells (ECs), induce proteolytic breakdown of ECM and enhance VEGF signaling. RUNX2, a transcription factor expressed...

... expand and are resorbed by osteoclasts then replaced by osteoblastic bone formation. Ephrin B2 is a receptor tyrosine kinase expressed by osteoblasts and growth plate chondrocytes that promotes osteoblast differentiation and inhibits osteoclast formation. We investigated the role of ephrin B2...

... genes. Resorption of bone matrix by osteoclasts is an obligatory process during bone growth, remodeling and fracture healing in mammals ( Väänänen et al., 2000 ). Moreover, osteoclasts have been shown to be involved in healing of fin ray fractures in Medaka ( Takeyama et al., 2014 ). Thus far...

... and osteoclasts using immunohistochemical staining analysis with specific TGF- β antibodies. TGF- β s in osteoclasts and chondroclasts were restricted to those cells located on the respective matrices. TGF- β 3 localization was mainly cytoplasmic in the transitional (early hypertrophic) chondrocytes, but nuclear...