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Keywords: Organoid
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Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (20): dev200614.
Published: 24 October 2022
... , and the diversity of epithelial cell types in culture is dependent on cell density. We also demonstrate that cultures can be grown in 2D or as 3D organoids, and these methods can be employed for modeling the complete epithelial layers, thereby enabling in vitro modeling of the human adult esophagus. Table 1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201052.
Published: 18 October 2022
... is limited by the lack of physiologically realistic three-dimensional (3D) in vitro models. Here, we report a self-organizing 3D neural tube organoid model derived from single mouse embryonic stem cells that exhibits an in vivo -like tissue architecture, cell type composition and anterior-posterior (AP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev200933.
Published: 22 September 2022
... medium provided that the original work is properly attributed. Summary: Emerging in vitro models of human development, such as blastoids, gastruloids and organoids, could be applied in prospective developmental toxicity testing, provided they are thoroughly validated and meet regulatory...
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (20): dev200613.
Published: 4 August 2022
... mechanisms and is associated with asymmetric segregation of mono- and polyubiquitylated damaged proteins. Further, forebrain regionalized organoids derived from hESCs were used to show the establishment of an ER membrane diffusion barrier in more naturalistic tissues, mimicking early steps of human brain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev188367.
Published: 25 June 2021
... to organoids, single-cell technology and clinical applications. Funding C.B. is supported by Austrian Science Fund (FWF) (P30599 and P34123). F.T.M. is a New York Stem Cell Foundation Robertson Investigator (NYSCF-R-156), and is supported by the Wellcome Trust and Royal Society (211221/Z/18/Z...
Journal Articles
Journal: Development
Development (2021) 148 (9): dev199386.
Published: 29 April 2021
... to maintain Ret expression. These cells move to the nascent tips, and remain there during many cycles of branching; this tip-seeking behavior may require positional signals from the mesenchyme, as it occurs in whole kidneys but not in epithelial ureteric bud organoids. In organoids, cells forced to express...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev191064.
Published: 17 July 2020
... Organoid Microphysiological model Sonic hedgehog A multifactorial model of birth defect etiology can be traced back to F. Clarke Fraser's research in the 1950s. At the time, the recent discovery that the uterus was not impervious to the environment led many developmental biologists to pursue...
Journal Articles
Journal: Development
Development (2019) 146 (21): dev177212.
Published: 1 November 2019
... also be dissociated to the single cell level and can regenerate a complete body axis from aggregates, behaving as natural organoids. In recent years, the ability to exploit Hydra has been expanded with the advent of new live-imaging approaches, genetic manipulations that include stable transgenesis...
Journal Articles
Journal: Development
Development (2019) 146 (14): dev175430.
Published: 25 July 2019
... distinct spatial dynamics of BMP signalling within the self-emerging epithelia of both mouse and human pluripotent stem cell-derived spinal organoids. The pattern of BMP signalling results in the stereotyped spatial arrangement of dorsal neural tube cell types, and concentration, timing and duration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev174557.
Published: 12 June 2019
... Lgr5 + hepatoblasts can be clonally expanded in vitro into embryonic liver organoids, which can commit to either hepatocyte or cholangiocyte fates. Our study demonstrates functional heterogeneity within E9.5 hepatoblasts and identifies Lgr5 as a marker for a subpopulation of bipotent liver progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (5): dev172361.
Published: 7 March 2019
...Santhosh V. Kumar; Pei X. Er; Kynan T. Lawlor; Ali Motazedian; Michelle Scurr; Irene Ghobrial; Alexander N. Combes; Luke Zappia; Alicia Oshlack; Edouard G. Stanley; Melissa H. Little ABSTRACT Kidney organoids have potential uses in disease modelling, drug screening and regenerative medicine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev156125.
Published: 18 May 2018
...-chip approach relative to organoids and other human cell cultures are also discussed. * Author for correspondence ( don.ingber@wyss.harvard.edu ) Competing interests D.E.I. holds equity in Emulate and chairs its scientific advisory board. © 2018. Published by The Company of Biologists...
Journal Articles
Journal: Development
Development (2018) 145 (6): dev153049.
Published: 14 March 2018
... provided a wealth of information about intestinal stem cells, whereas less is known about human intestinal stem cells owing to difficulty detecting and isolating these cells. We established an organoid repository from patient-derived adenomas, adenocarcinomas and normal colon, which we analyzed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev156166.
Published: 8 March 2018
... at the three-dimensional (3D) level. Recent bioengineering approaches have begun to combine different 3D organoid types into a single ‘4D multi-organ system’. We summarize the advantages of this approach and speculate on the future role of 4D multi-organ systems in human disease modeling. * Author...
Journal Articles
Journal: Development
Development (2018) 145 (1): dev155838.
Published: 9 January 2018
... of clinically relevant, light-focusing micro-lenses. Lens development Stem cell Organoid Focus Cataract Vx-770 During embryogenesis, the ocular lens arises from the lens placode in the surface ectoderm opposite the optic cup ( Mann, 1964 ; Tholozan and Quinlan, 2007 ). Although the exact...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2099–2103.
Published: 15 June 2017
... (University of Cambridge, UK) discussed the impact of transposons and their methylation status on non-genetic inheritance of certain traits in mice ( Miska and Ferguson-Smith, 2016 ). Readers will be aware that the late Yoshiki Sasai opened up the organoid research area, taking advantage of the self...
Journal Articles
Journal: Development
Development (2017) 144 (9): 1584–1587.
Published: 1 May 2017
...J. Gray Camp; Barbara Treutlein Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these ‘organoids’ into constituent...
Journal Articles
Journal: Development
Development (2017) 144 (6): 998–1007.
Published: 15 March 2017
...Lyndsay M. Murrow; Robert J. Weber; Zev J. Gartner ABSTRACT For many tissues, single resident stem cells grown in vitro under appropriate three-dimensional conditions can produce outgrowths known as organoids. These tissues recapitulate much of the cell composition and architecture of the in vivo...
Journal Articles
Journal: Development
Development (2017) 144 (6): 1107–1112.
Published: 15 March 2017
...Norman Sachs; Yoshiyuki Tsukamoto; Pekka Kujala; Peter J. Peters; Hans Clevers ABSTRACT Multiple recent examples highlight how stem cells can self-organize in vitro to establish organoids that closely resemble their in vivo counterparts. Single Lgr5 + mouse intestinal stem cells can be cultured...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 1045–1055.
Published: 15 March 2017
... human embryonic stem cell-derived intestinal organoids, we demonstrate that the duration of exposure to active FGF and WNT signaling controls regional identity. Short-term exposure to FGF4 and CHIR99021 (a GSK3β inhibitor that stabilizes β-catenin) resulted in organoids with gene expression patterns...
Includes: Supplementary data