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Keywords: Organoid
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Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (11): dev201284.
Published: 1 June 2023
...Shuyu Liu; Dawei Sun; Richard Butler; Emma L. Rawlins ABSTRACT Multipotent epithelial progenitor cells can be expanded from human embryonic lungs as organoids and maintained in a self-renewing state using a defined medium. The organoid cells are columnar, resembling the cell morphology...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (10): dev201619.
Published: 26 May 2023
... additional p53-independent mechanisms contribute to later stages. Live imaging of mouse and human neural progenitors reveals that Eif4a3 controls mitosis length, which influences progeny fate and viability. These phenotypes are conserved, as cortical organoids derived from RCPS iPSCs exhibit aberrant...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (4): dev201375.
Published: 16 February 2023
... is variably expressed among CVP epithelial cells, suggesting that their progenitor potential may vary. Using transcriptome analysis and organoid technology, we show that cells expressing SOX2 at higher levels are taste-competent progenitors that give rise to organoids comprising both TRCs and lingual...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (20): dev200614.
Published: 24 October 2022
... , and the diversity of epithelial cell types in culture is dependent on cell density. We also demonstrate that cultures can be grown in 2D or as 3D organoids, and these methods can be employed for modeling the complete epithelial layers, thereby enabling in vitro modeling of the human adult esophagus. Competing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201052.
Published: 18 October 2022
... is limited by the lack of physiologically realistic three-dimensional (3D) in vitro models. Here, we report a self-organizing 3D neural tube organoid model derived from single mouse embryonic stem cells that exhibits an in vivo -like tissue architecture, cell type composition and anterior-posterior (AP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev200933.
Published: 22 September 2022
.... In the mouse context, 3D gastruloids with more advanced features, such as somite development ( Veenvliet et al., 2020 ) and beating heart-like structures ( Rossi et al., 2021 ), have been generated, although no such improved human gastruloid models have been reported yet. Finally, human organoids could...
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (20): dev200613.
Published: 4 August 2022
... mechanisms and is associated with asymmetric segregation of mono- and polyubiquitylated damaged proteins. Further, forebrain regionalized organoids derived from hESCs were used to show the establishment of an ER membrane diffusion barrier in more naturalistic tissues, mimicking early steps of human brain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev188367.
Published: 25 June 2021
... to organoids, single-cell technology and clinical applications. Over 3 days, the symposium covered different aspects of stem cell research ranging from early embryonic development and organogenesis to disease modelling and clinical applications. The symposium was anchored by outstanding keynote presentations...
Journal Articles
Journal: Development
Development (2021) 148 (9): dev199386.
Published: 29 April 2021
... to maintain Ret expression. These cells move to the nascent tips, and remain there during many cycles of branching; this tip-seeking behavior may require positional signals from the mesenchyme, as it occurs in whole kidneys but not in epithelial ureteric bud organoids. In organoids, cells forced to express...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev191064.
Published: 17 July 2020
... Organoid Microphysiological model Sonic hedgehog A multifactorial model of birth defect etiology can be traced back to F. Clarke Fraser's research in the 1950s. At the time, the recent discovery that the uterus was not impervious to the environment led many developmental biologists to pursue...
Journal Articles
Journal: Development
Development (2019) 146 (21): dev177212.
Published: 1 November 2019
... also be dissociated to the single cell level and can regenerate a complete body axis from aggregates, behaving as natural organoids. In recent years, the ability to exploit Hydra has been expanded with the advent of new live-imaging approaches, genetic manipulations that include stable transgenesis...
Journal Articles
Journal: Development
Development (2019) 146 (14): dev175430.
Published: 25 July 2019
... distinct spatial dynamics of BMP signalling within the self-emerging epithelia of both mouse and human pluripotent stem cell-derived spinal organoids. The pattern of BMP signalling results in the stereotyped spatial arrangement of dorsal neural tube cell types, and concentration, timing and duration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev174557.
Published: 12 June 2019
... Lgr5 + hepatoblasts can be clonally expanded in vitro into embryonic liver organoids, which can commit to either hepatocyte or cholangiocyte fates. Our study demonstrates functional heterogeneity within E9.5 hepatoblasts and identifies Lgr5 as a marker for a subpopulation of bipotent liver progenitors...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (16): dev156125.
Published: 18 May 2018
...-chip approach relative to organoids and other human cell cultures are also discussed. * Author for correspondence ( don.ingber@wyss.harvard.edu ) Competing interests D.E.I. holds equity in Emulate and chairs its scientific advisory board. © 2018. Published by The Company of Biologists...
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (5): dev156166.
Published: 8 March 2018
... at the three-dimensional (3D) level. Recent bioengineering approaches have begun to combine different 3D organoid types into a single ‘4D multi-organ system’. We summarize the advantages of this approach and speculate on the future role of 4D multi-organ systems in human disease modeling. * Author...
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (12): 2099–2103.
Published: 15 June 2017
... and our evolutionary history. Human development Single-cell sequencing Epigenetics Organoid Evolution Developmental biology research has a long history of studying model organisms such as the fruit fly Drosophila melanogaster , focusing mainly on early embryogenesis. One major...