...-specific patterning is explained by intersecting morphogenic and transcriptional organizing principles. Gonad Organogenesis Sertoli Sex determination SRY Testis Urogenital National Institutes of Health http://dx.doi.org/10.13039/100000002 R01-HD039963 R37-HD039963 ...

... to recapitulate different stages of early mammalian development. Here, we examine the wide variety of stem cell-based embryo models that have been developed to recapitulate and study embryonic events, from pre-implantation development through to early organogenesis. We discuss the applications of these models...

... of nephron progenitors during renal development. Organogenesis Tissue-specific progenitors Pycr1/Pycr2 Self-renewal Differentiation Development Metabolism Receptor tyrosine kinase signaling Intracellular signaling cascades Academy of Finland http://dx.doi.org/10.13039/501100002341...

... during Caenorhabditis elegans vulval development to link the vulva and uterus as they form. Caenorhabditis elegans Epidermal growth factor Organogenesis Microfluidics Kanton Zürich Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung http...

... embryonic development, and highlight the presence of largely autonomous but interconnected developmental modules that orchestrate organogenesis. * Present address: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany. ‡ Author...

... interpretation of developmental studies in those systems. Pancreas Metabolism Organogenesis β-Cell α-Cell δ-cell Diabetes mellitus Pig Highlighted Article: Transcriptional, signaling and cellular programs governing pig pancreatic islet development exhibit striking similarities to human...

... framework to further investigate the mechanisms involved. FGF signaling Myogenesis Organogenesis Myotube guidance Rho GTPase Actin cytoskeleton Heartless Drosophila embryogenesis In mature skeletal muscle, myofibers are perfectly aligned with the skeleton so that muscle contractions...

... of the developing kidney. Kidney development Single cell RNA-seq Organogenesis Nephron progenitor Ureteric epithelium Mammalian kidney development has been studied using the mouse for over 70 years. The developing mammalian kidney consists of three main cell lineages, all of which derive from...

...Eric D. Bankaitis; Matthew E. Bechard; Guoqiang Gu; Mark A. Magnuson; Christopher V. E. Wright ABSTRACT During mouse pancreas organogenesis, endocrine cells are born from progenitors residing in an epithelial plexus niche. After a period in a lineage-primed Neurog3 LO state, progenitors become...

... haustorium organogenesis in parasitic plants. * Author for correspondence ( ken.shirasu@riken.jp ) Competing interests The authors declare no competing or financial interests. 7 3 2018 18 6 2018 © 2018. Published by The Company of Biologists Ltd 2018 This is an Open Access...

...-Kishore , R. , White , J. G. , Southgate , E. and Podbilewicz , B. ( 1999 ). Formation of the vulva in C. elegans: a paradigm for organogenesis . Development   126 , 691 - 699 . Shemer , G. and Podbilewicz , B. ( 2002 ). LIN-39/Hox triggers cell division and represses...

... and their translation into the clinic reported at this 2017 EMBO Conference. Stem cell Regenerative medicine Epigenetics Metabolism Regulation Organogenesis One of the ultimate goals of stem cell biologists is to learn more about the development, homeostasis and regeneration of organisms...

... to underlie pancreas development, from induction and lineage formation to morphogenesis and organogenesis. Elucidating such principles will help to identify novel candidate disease genes and unravel the pathogenesis of pancreas-related diseases, such as diabetes, pancreatitis and cancer. Fig. 1...

... cells provides a detailed spatiotemporal analysis of marker expression and tissue formation during corneal development. Human induced pluripotent stem cells Ocular differentiation Organogenesis Corneal organoids Cornea is the transparent, avascular tissue on the ocular surface through...

...J. Gray Camp; Barbara Treutlein Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these ‘organoids’ into constituent...

... the measurements performed in organoids to understand the role of chemical diffusion, contact signaling, differential cell adhesion and mechanical controls. Here, we discuss what it means to take a biophysical approach to understanding organogenesis in vitro and how we might expect such approaches to develop...

... and reproduction in any medium provided that the original work is properly attributed. Summary: Two parallel sensory lines in medaka share a common origin and are composed of identical organs that are, nevertheless, generated through different morphogenetic programmes. Organogenesis Lateral line...

...://www.biologists.com/user-licence-1-1/ Summary: Lineage tracing approaches in zebrafish reveal that intestinal smooth muscle originates from the lateral plate mesoderm. Migration and differentiation of these cells involves TGFβ signaling. Zebrafish Organogenesis Lateral plate mesoderm Smooth muscle...

... direct evidence of an anteroposterior nuclear β-CATENIN-1 gradient in adult planarians and uncover novel, context-dependent roles for β-catenin-1 during anterior regeneration and organogenesis. * Author for correspondence ( tadellc@ub.edu ) Competing interests The authors declare no competing...

... birth owing to organogenesis defects as in ciliopathies. Shh signaling is impaired in null embryos and primary cilia are reduced in multiple tissues. We show that CP110 is required for anchoring of basal bodies to the membrane during cilia formation. CP110 loss resulted in an abnormal distribution...