... of order/disorder as well as symmetry/asymmetry, revealing developmental instabilities that are part of normal morphogenesis. Craniofacial Avian embryo Frontonasal Fluctuating asymmetry Mathematical analysis Live cell imaging Organ culture Actomyosin Facial morphogenesis requires...

... Branching morphogenesis Organ culture Organoid Receptor tyrosine kinase To examine the sequence of events that caused the recombinant UB cells, which express either Rosa26 RetWT or Rosa26 RetPTC2 , to become localized to the UB tips, we induced Ret CreERT2 with tamoxifen at E9.5...

... attributed. Summary: Time-lapse confocal imaging of organoids and embryonic tissues through fixed z -direction culture allows long-term single-cell resolution live imaging of tissue growth and morphogenesis. Kidney Organ culture Time-lapse Organoid, Imaging High-resolution confocal...

... of Notch signaling components, including Jag1, Hes5 and in a manner consistent with reduced Notch signaling,and correlated with increases in hair cell and support cell differentiation. The disruption of Notch signaling by a γ-secretase inhibitor in an in vitro organ culture system of wild-type cochleae...

... regression in organ culture. Müllerian duct regression can also be inhibited or accelerated by siRNA targeting Smad8 and Smad5 ,respectively. Thus, the early action of MIS is to initiate an epithelial-to-mesenchymal transition of MISRII-expressing cells and to specify the components of the receptor/SMAD...

... FGF10 Signaling Salivary gland development Organ culture Fibroblast growth factors (FGFs), a family of 23 growth factors, are crucial for many developmental processes, including branching morphogenesis( Martin, 1998 ; Ornitz, 2000 ). Multiple FGF and FGF receptor (FGFR) isoforms...

... and analyzed the developmental expression patterns of other FGFR and FGF isoforms. The functional significance of FGFR1 was confirmed by submandibular gland organ culture. Antisense oligonucleotides decreased expression of FGFR1 and reduced branching morphogenesis of the glands. Inhibiting FGFR1 signaling...

..., we investigated the mechanisms by which TGF-β3 deletions caused cleft palate in 129 × CF-1 mice. For organ culture, palatal shelves were dissected from embryonic day 13.5 (E13.5) mouse embryos. Palatal shelves were placed singly or in pairs on Millipore filters and cultured in DMEM/F12 medium...

... 14 12 1992 © 1993 by Company of Biologists 1993 N -myc targeted gene disruption ES cells organogenesis limb buds organ culture mouse It is a widely accepted notion that proto-oncogenes have essential regulatory functions in normal ontogenesis. Many of them are expressed...

.... * Present address and address for correspondence: Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK 19 10 1992 © 1993 by Company of Biologists 1993 odontogenesis organ culture in situ hybridization The murine first molar tooth develops...

... of Biologists 1992 E-cadherin En brain morphogenesis organ culture mouse embryo Morphogenesis of the brain is regulated by a complex series of cellular interactions. One of these processes, the specific adhesion of cells, is assumed to be important. Various classes of adhesion molecules...

...Setsunosuke Ihara; Yumiko Motobayashi ABSTRACT Foetal rat skin rapidly closes an open wound in organ culture and in vivo , this possibly being unique to organs still in the morphogenetic stage. In the present study, examination was made of morphological changes in foetal rat skin during closure...

...G. G. Altmann; A. Quaroni ABSTRACT A model of organ culture of 18 day old fetal rat intestine (Quaroni, 1985) was modified and characterized in the present work with the purpose of developing an in vitro model for the study of intestinal epithelial cell behaviour. Fragments of this intestine were...

...H. Sobis; J. Goebels; M. Vandeputte ABSTRACT The proliferation and differentiation potentiality of the rat visceral yolk sac was investigated both in organ culture and after grafting in vivo . Using alkaline phosphatase as a marker for germ cells, it was shown that these cells are absent in the 12...

... embryos. Secondary cartilage did form when clavicles were organ cultured, either submerged, or at the air-medium interface. This stands in contrast to craniofacial membrane bone such as the quadratojugal, which only forms secondary cartilage in vitro when cultured submerged. Growth of the clavicle...