... ). To determine whether differentiated neurons were also affected by Snr1 RNAi in neuroepithelial cells, our scRNA-seq was used to identify differentially expressed temporal markers of optic lobe neurons ( Konstantinides et al., 2022 ; Li et al., 2013 ; Zhu et al., 2022 ). Of the series of known early...

...-carbon cycle, during Drosophila brain development. We show that, although loss of Shmt does not cause obvious defects in the central brain, it leads to severe phenotypes in the optic lobe. The shmt mutants have smaller optic lobe neuroepithelia, partly justified by increased apoptosis. In addition, shmt...

... work is properly attributed. Summary: RNA interference identifies SoxN and Sox102F as key regulators of the morphological properties of a neuronal type of the fruit fly visual system that computes the direction of motion. Neural development Layer specificity Optic lobe Drosophila...

... in the optic lobe during early larval stages by boosting symmetric self-renewing divisions while preventing differentiation. Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of neural stem cell...

...Eri Hasegawa; Yusuke Kitada; Masako Kaido; Rie Takayama; Takeshi Awasaki; Tetsuya Tabata; Makoto Sato The Drosophila optic lobe comprises a wide variety of neurons, which form laminar neuropiles with columnar units and topographic projections from the retina. The Drosophila optic lobe shares many...

...Javier Morante; Ted Erclik; Claude Desplan In the developing Drosophila optic lobe, eyeless, apterous and distal-less , three genes that encode transcription factors with important functions during development, are expressed in broad subsets of medulla neurons. Medulla cortex cells follow two...

...Boris Egger; Katrina S. Gold; Andrea H. Brand The proper balance between symmetric and asymmetric stem cell division is crucial both to maintain a population of stem cells and to prevent tumorous overgrowth. Neural stem cells in the Drosophila optic lobe originate within a polarised neuroepithelium...

... at pupariation and died at head eversion. They showed premature ecdysone receptor B1 (EcR-B1) in the photoreceptors and in the optic lobe, downregulation of proliferation in the optic lobe, and separation of R7 from R8 in the medulla during the prepupal period. All of these effects of allatectomy were reversed...

.... In contrast to the wiring defects described above, however, we demonstrate that these aberrations are not caused by defects in photoreceptor innervation or changes in cell fate of target neurons within the brain. Instead, they result primarily from reduced proliferation within the optic lobe and central brain...

...Timothy D. Tayler; Myles B. Robichaux; Paul A. Garrity Brain morphogenesis depends on the maintenance of boundaries between populations of non-intermingling cells. We used molecular markers to characterize a boundary within the optic lobe of the Drosophila brain and found that Slit and the Robo...

... brain/eye anlage. Dpp is secreted in the dorsal midline of the head. Lowering Dpp levels (in dpp heterozygotes or hypomorphic alleles) results in a ‘cyclops’ phenotype, where mid-dorsal head epidermis is transformed into dorsolateral structures, i.e. eye/optic lobe tissue, which causes a continuous...

... visual system. The embryonic visual system consists of the optic lobe primordium, which, during later larval life, develops into the prominent optic lobe neuropiles, and the larval photoreceptor (Bolwig’s organ). Both structures derive from a neurectodermal placode in the embryonic head. Expression...

...David T. Champlin; James W. Truman ABSTRACT Cell proliferation within the optic lobe anlagen is dependent on ecdysteroids during metamorphosis of the moth Manduca sexta . We use cultured tissues to show that ecdysteroids must be maintained above a sharp threshold concentration to sustain...

...Margaret L. Winberg; Sharon E. Perez; Hermann Steller ABSTRACT We have examined the generation and development of glial cells in the first optic ganglion, the lamina, of Drosophila melanogaster . Previous work has shown that the growth of retinal axons into the developing optic lobes induces...