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Keywords: Optic fissure
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Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (24): dev193649.
Published: 28 December 2020
...Aara Patel; Glenn Anderson; Gabriel L. Galea; Monika Balys; Jane C. Sowden ABSTRACT Ocular coloboma is a congenital eye malformation, resulting from a failure in optic fissure closure (OFC) and causing visual impairment. There has been little study of the epithelial fusion process underlying...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2711–2723.
Published: 1 July 2013
..., ocular coloboma. Defective FGF signaling does not abrogate Shh or BMP signaling, nor does it affect axial patterning of the optic vesicle. Instead, FGF signaling regulates Mitf and Pax2 in coordinating the closure of the optic fissure and optic disc specification, which is necessary for the outgrowth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (21): 3567–3576.
Published: 1 November 2008
... (Fz5; Fzd5) Microphthalmia Optic fissure PFV Retinal degeneration Eye development is perturbed in a wide variety of syndromic and non-syndromic disorders. Among the more common defects are microphthalmia,coloboma (congenital ocular fissure) and persistent fetal vasculature (PFV)within...
Journal Articles
Journal: Development
Development (2006) 133 (16): 3179–3190.
Published: 15 August 2006
... fissure BMP SHH The optic disc (OD or blind spot of the retina) is the region of the retina where the optic fibres converge to become part of the optic nerve. This structure constitutes the interface between the optic stalk and the retina,and develops from the edges of the optic fissure...
Includes: Supplementary data