... of the subventricular zone (SVZ) and generate multiple olfactory bulb (OB) interneuron subtypes in the adult brain. However, the molecular mechanisms underlying such NSC heterogeneity remain largely unknown. Here, we show that the basic helix-loop-helix transcription factor Olig2 defines a subset of NSCs in the early...

... cell differentiation in various contexts has remained elusive. Here, we studied the role of Zeb2 and its domains in neurogenesis and neural differentiation in the young postnatal ventricular-subventricular zone (V-SVZ), in which neural stem cells generate olfactory bulb-destined interneurons...

... of mature neurons. Many transcription factors are continuously expressed during this process but it is presently unclear how these factors modify their targets as cells transition through different stages of specification. In olfactory bulb adult neurogenesis, the transcription factor PBX1 controls...

... for neuroendocrine neurons to migrate into the hypothalamus and release gonadotropins into the circulation. GnRH neuron Olfactory bulb Testes Axon guidance Plexin Semaphorin Hypogonadotropic hypogonadism Kallmann syndrome GnRH-secreting neurons are hypothalamic neuroendocrine cells that regulate...

... progenitors, resulting in the ectopic expression of Gsx2 and massive production of GABAergic olfactory bulb interneurons in the dorsal telencephalon. Furthermore, double-mutant progenitors in the medial region exhibit upregulated Pax6 and more lateral characteristics. These ventral and lateral shifts...

...Neelima Vaddadi; Katrine Iversen; Reesha Raja; Alina Phen; Alexandra Brignall; Emilie Dumontier; Jean-François Cloutier ABSTRACT The formation of olfactory maps in the olfactory bulb (OB) is crucial for the control of innate and learned mouse behaviors. Olfactory sensory neurons (OSNs) expressing...

... studies, as exemplified by transient overexpression of the neurogenic factor Myt1l and by stably inactivating Dicer nuclease in vivo in adult born olfactory bulb interneurons and in fully integrated cortical projection neurons. * These authors contributed equally to this work ‡ Author...

... cells, which in turn generate neuroblasts that migrate along the rostral migratory stream (RMS) to the olfactory bulb (OB). Here, we have examined the role of the COUP-TFI and COUP-TFII orphan nuclear receptor transcription factors in mouse OB interneuron development. We observed that COUP-TFI...

...Malin Åkerblom; Rebecca Petri; Rohit Sachdeva; Thies Klussendorf; Bengt Mattsson; Bernhard Gentner; Johan Jakobsson New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found...

.... , Estevez A. G. , Baker H. , Cave J. W. ( 2009 ). gamma-Aminobutyric acid-mediated regulation of the activity-dependent olfactory bulb dopaminergic phenotype . J. Neurosci. Res. 87 , 2211 – 2221 . Altman J. ( 1969 ). Autoradiographic and histological studies of postnatal...

... that is severely affected in human ciliopathies. Here, we study telencephalic morphogenesis in a mouse mutant for the ciliopathy gene Ftm ( Rpgrip1l ). We show that the olfactory bulbs are present in an ectopic location in the telencephalon of Ftm −/− fetuses and do not display morphological outgrowth at the end...

...Andreas Walz; Paul Feinstein; Mona Khan; Peter Mombaerts The olfactory system of the mouse includes several subsystems that project axons from the olfactory epithelium to the olfactory bulb. Among these is a subset of neurons that do not express the canonical pathway of olfactory signal...

...Eduardo Gascon; Laszlo Vutskits; Benoit Jenny; Pascale Durbec; Jozsef Zoltan Kiss In the mammalian brain, ongoing neurogenesis via the rostral migratory stream (RMS) maintains neuronal replacement in the olfactory bulb throughout life. Mechanisms that regulate the final number of new neurons...

.... To reveal its function, we generated Fez -deficient mice. The Fez -deficient mice showed several abnormalities in the olfactory system: (1) impaired axonal projection of the olfactory sensory neurons; (2) reduced size of the olfactory bulb; (3)abnormal layer formation in the olfactory bulb; and (4) aberrant...

... of the Arx homeobox gene in the developing olfactory system by analyzing its mutant phenotypes. Arx protein was expressed strongly in the interneurons and weakly in the radial glia of the olfactory bulb, but in neither the olfactory sensory neurons nor bulbar projection neurons. Arx -deficient mice showed...

...Tadashi Nomura; Noriko Osumi The olfactory bulb is a protruding structure formed at the rostral end of the telencephalon. Pax6 -mutant mice and rats lack the olfactory bulb and, instead, develop an olfactory bulb-like structure at the lateral part of the telencephalon. Here, we report that ectopic...

... and the medial ganglionic eminence, the rostral telencephalon also gives rise to oligodendrocytes. We show that oligodendrocytes in the olfactory bulb are generated within the rostral pallium from ventricular progenitors characterized by the expression of Plp . We provide evidence that these Plp oligodendrocyte...