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Keywords: Nuclear receptor
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Journal Articles
Journal: Development
Development (2014) 141 (20): 3955–3965.
Published: 15 October 2014
... by the sequential expression of the nuclear receptors E75, DHR3 and βFtz-f1, representing a model for steroid hormone signalling. Here, we have combined genetic and imaging approaches to investigate the precise role of this signalling cascade within theprothoracic gland (PG), where ecdysone synthesis takes place...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3549–3562.
Published: 15 September 2006
...Laura Palanker; Aleksandar S. Necakov; Heidi M. Sampson; Ruoyu Ni; Chun Hu; Carl S. Thummel; Henry M. Krause Nuclear receptors are a large family of transcription factors that play major roles in development, metamorphosis, metabolism and disease. To determine how, where and when nuclear receptors...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (17): 4189–4200.
Published: 1 September 2004
... encoded by Hr (HR) functions as a nuclear receptor co-repressor. To address the role of HR in vivo, we generated a loss-of-function ( Hr -/- ) mouse model. The Hr -/- phenotype includes both hair loss and severe wrinkling of the skin. Wrinkling is correlated with increased cell proliferation...
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (7): 1739–1750.
Published: 1 April 2002
...Tatiana Kozlova; Carl S. Thummel Ecdysteroid signaling in insects is transduced by a heterodimer of the EcR and USP nuclear receptors. In order to monitor the temporal and spatial patterns of ecdysteroid signaling in vivo we established transgenic animals that express a fusion of the GAL4 DNA...
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (11): 2049–2062.
Published: 1 June 2001
... ) 8 3 2001 © 2001. 2001 Nuclear receptor Retinoic acid Gene knockout Transcriptional activity Activation function Placenta Limb Mouse Retinoids (vitamin A derivatives) are crucial for many aspects of vertebrate physiology and homeostasis (reviewed in Sporn et al., 1994...
Journal Articles
Journal: Development
Development (1998) 125 (23): 4709–4717.
Published: 1 December 1998
... development. * Author for correspondence (e-mail: carl.thummel@genetics.utah.edu ) 25 10 1998 9 11 1998 © 1998 by Company of Biologists 1998 Nuclear receptor Gene regulation Metamorphosis Juvenile hormone Drosophila Ecdysone receptor RXR Ultraspiracle...
Journal Articles
Journal: Development
Development (1994) 120 (7): 1861–1872.
Published: 1 July 1994
... ). 9-cis retinoic acid stereoisomer bind and activates the nuclear receptor RXRα . Nature 355 , 359 – 361 . 10.1038/355359a0 Maden , M. ( 1982 ). Vitamin A and pattern formation in the regenerating limb . Nature 295 , 672 – 675 . 10.1038/295672a0 Nagpal , S...
Journal Articles
Journal: Development
Development (1992) 115 (2): 449–462.
Published: 1 June 1992
.... This contrasts with other Drosophila nuclear receptors such as tailless ( Steingrimsson et al., 1991 ) and other transcription factors, such as fushi tarazu ( Struhl, 1985 ), for which ectopic expression results in distinctive alterations in development. One possible explanation for the benign behavior...