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Keywords: Notochord
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Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (10): dev200252.
Published: 16 May 2022
... and that they are later incorporated in the anterior notochord. Our analysis of notochord formation in wild type and in embryos in which FGF signalling is inhibited also reveals that amphioxus anterior notochord presents transient prechordal plate features. Altogether, our results give insight into how changes in FGF...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (16): dev199430.
Published: 20 August 2021
... across different organisms. Here, we apply a quantitative approach to learn how the notochord forms during the development of amphioxus: a basally branching chordate. Using a single-cell morphometrics pipeline, we quantify the geometries of thousands of amphioxus notochord cells, and project them...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199459.
Published: 21 July 2021
...Susannah B. P. McLaren; Benjamin J. Steventon ABSTRACT How force generated by the morphogenesis of one tissue impacts the morphogenesis of other tissues to achieve an elongated embryo axis is not well understood. The notochord runs along the length of the somitic compartment and is flanked...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev195230.
Published: 5 February 2021
...Wendy M. Reeves; Kotaro Shimai; Konner M. Winkley; Michael T. Veeman ABSTRACT The notochord is a defining feature of the chordates. The transcription factor Brachyury (Bra) is a key regulator of notochord fate but here we show that it is not a unitary master regulator in the model chordate Ciona...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (21): dev175794.
Published: 6 October 2020
..., and highlight open questions. We specifically focus on the processes of notochord development and cerebrospinal fluid physiology, and how defects in those processes may lead to scoliosis. * Authors for correspondence ( michel.bagnat@duke.edu , ryan.gray@austin.utexas.edu ) Competing interests...
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (18): 3375–3387.
Published: 15 September 2017
...Wendy M. Reeves; Yuye Wu; Matthew J. Harder; Michael T. Veeman The notochord of the ascidian Ciona consists of only 40 cells, and is a longstanding model for studying organogenesis in a small, simple embryo. Here, we perform RNAseq on flow-sorted notochord cells from multiple stages to define...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (10): 1733–1744.
Published: 15 May 2015
... that the notochord plays an instructive role in segmental patterning, alongside the somites, and contributes to mineralization. By clarifying the evolutionary relationship between centra and arches, and their varying modes of skeletal mineralization, we can better appreciate the detailed mechanisms that regulate...
Journal Articles
Journal: Development
Development (2015) 142 (9): 1639–1650.
Published: 1 May 2015
...Elsa Denker; Ivonne M. Sehring; Bo Dong; Julien Audisso; Birthe Mathiesen; Di Jiang Regulation of lumen growth is crucial to ensure the correct morphology, dimensions and function of a tubular structure. How this is controlled is still poorly understood. During Ciona intestinalis notochord...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1516–1527.
Published: 15 April 2015
... A-P axis elongation. Both genes regulate trunk notochord extension through PCP-controlled CE of notochord cells, establishing a role for Wnt11 in mammalian PCP. We show that Wnt5a and Wnt11 are required for proper patterning of the neural tube and somites by regulating notochord formation, and provide...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 692–701.
Published: 15 February 2015
... environmental and genetic variation that might otherwise perturb development and growth. (3) Force production is distributed between neural and mesodermal tissues in the dorsal isolate, and the notochord, a central structure involved in patterning vertebrate morphogenesis, is not required for force production...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (11): 2422–2433.
Published: 1 June 2013
...Diana S. José-Edwards; Izumi Oda-Ishii; Yutaka Nibu; Anna Di Gregorio T-box genes are potent regulators of mesoderm development in many metazoans. In chordate embryos, the T-box transcription factor Brachyury (Bra) is required for specification and differentiation of the notochord. In some...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (22): 4943–4953.
Published: 15 November 2011
... signaling. More broadly, genome-wide target extraction with validation using an in vivo tissue-specific sensor assay indicates that miR-124 shapes neuronal progenitor fields by downregulating non-neural genes, notably the muscle specifier Macho-1 and 50 Brachyury-regulated notochord genes, as well...
Includes: Supplementary data