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Keywords: Notch1
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Journal Articles
Journal: Development
Development (2021) 148 (7): dev197319.
Published: 15 April 2021
... that a conditional knockout of Yy1 in the hematopoietic system results in an early T cell developmental blockage at the double negative (DN) 1 stage with reduced Notch1 signaling. There is a lineage-specific requirement for YY1 PcG function. YY1 PcG domain is required for T and B cell development but not necessary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2629–2639.
Published: 15 July 2017
... not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human NOTCH1 and zebrafish notch1b genes. These enhancers were able...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1193–1202.
Published: 15 March 2015
...Zhenyi Liu; Eric Brunskill; Scott Boyle; Shuang Chen; Mustafa Turkoz; Yuxuan Guo; Rachel Grant; Raphael Kopan We have previously described the creation and analysis of a Notch1 activity-trap mouse line, Notch1 intramembrane proteolysis-Cre6MT or N1IP::Cre LO , that marked cells experiencing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2365–2376.
Published: 1 June 2013
... studies suggested that Jag1/Notch1 signaling functions in veins during lymphatic endothelial specification. Using an inducible lymphatic endothelial Prox1CreER T2 driver, Notch signaling was suppressed by deleting Notch1 or expressing dominant-negative Mastermind-like in Prox1+ endothelial cells. Either...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1946–1957.
Published: 1 May 2013
... within the developing endocardia in regulating the morphogenesis of ventricular trabeculation and compaction. Further analysis demonstrated that Fkbp1a is a novel negative modulator of activated Notch1. Activated Notch1 (N1ICD) was significantly upregulated in Fkbp1a -ablated endothelial cells in vivo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (13): 2251–2261.
Published: 1 July 2008
... epidermis, and that Wnt signaling mediates this placode-epidermis fate decision. We now present evidence for reciprocal interactions between the Wnt and Notch signaling pathways during inner ear induction. Activation of Notch1 in Pax2 + ectoderm expands the placodal epithelium at the expense of cranial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (19): 3427–3436.
Published: 1 October 2007
... in experiments conducted using mouse and chick that Foxn4 induces expression of delta-like 4 (Dll4) and Mash1 (Ascl1). Dll4 then signals through Notch1 to subdivide the p2 progenitor pool. Foxn4, Mash1 and activated Notch1 trigger the genetic cascade leading to V2b INs, whereas the complementary set...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (15): 2795–2806.
Published: 1 August 2007
...Jonghyeob Lee; Jacob M. Basak; Shadmehr Demehri; Raphael Kopan Notch1-deficient epidermal keratinocytes become progressively hyperplastic and eventually produce tumors. By contrast, Notch1-deficient hair matrix keratinocytes have lower mitotic rates, resulting in smaller follicles with fewer cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1553–1563.
Published: 15 April 2006
... formation develops normally. The N-terminally truncated isoform of p63(ΔNp63) was expressed at high levels in embryonic ectoderm at all stages of tooth and hair development, and it was already dominant over the transactivating TAp63 isoform prior to epidermal stratification. Bmp7,Fgfr2b, Jag1 and Notch1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (7): 1367–1378.
Published: 1 April 2006
...Orly Yaron; Chen Farhy; Till Marquardt; Meredithe Applebury; Ruth Ashery-Padan Notch receptor-mediated cell-cell signaling is known to negatively regulate neurogenesis in both vertebrate and invertebrate species, while being implicated in promoting the acquisition of glial fates. We studied Notch1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (19): 4247–4258.
Published: 1 October 2005
... on gain-of-function approaches because perturbation of Notch signaling results in death prior to the onset of neurogenesis. Here, we examine the requirement for Notch signaling in the development of the striatum through the analysis of different single and compound Notch1 conditional and Notch3 null...
Journal Articles
Journal: Development
Development (2002) 129 (5): 1175–1183.
Published: 1 March 2002
... deltaC precede somite formation. Our study focuses on how the oscillations in the expression of these two genes is affected in the mutants aei / deltaD and des / notch1 , in ‘morpholino knockdowns’ of deltaC and her1 and in double ‘mutant’ combinations. This analysis indicates that these oscillations...