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Keywords: Notch signalling
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Journal Articles
Journal: Development
Development (2021) 148 (1): dev191437.
Published: 10 January 2021
... activation relies on the correct localization of the Notch signalling actors. We report that AP-1 and Stratum ensure the basolateral targeting of Notch during asymmetric cell division. Notch signalling Intracellular trafficking Asymmetric cell division Stratum AP-1 Cell-cell signalling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev191544.
Published: 23 November 2020
... asymmetric cell division, progenitors send a Delta-Notch signal to their sibling stem cells. Here, we show that excessive activation of Notch or overexpression of its direct targets of the Hes family causes stem-cell hyperplasias in the Drosophila larval central nervous system, which can progress...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev183665.
Published: 17 February 2020
.... Notch signalling regulates the balance between the rostral and caudal domains: high levels of Notch signalling expand the caudal domain at the expense of the rostral domain, whereas loss of Notch signalling produces the converse phenotype. Collectively, these data unravel a new patterning principle...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (1): dev166595.
Published: 9 January 2019
... of Notch signalling disrupts the maintenance of this zone. When Notch is blocked, progenitor cells differentiate precociously, the proliferative ventricular zone is lost and differentiation markers become expressed throughout the spinal cord. Comparison with other chordates suggests that the emergence...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (24): 4701–4712.
Published: 15 December 2016
... Photoreceptor Notch signalling Atonal homolog 7 Fibroblast growth factor 3 Neurogenin 2 Primate retinas are characterised by a specialised central region, the macula, while their periphery resembles that of other mammals. The macula is subdivided into different areas, including the fovea...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2305–2310.
Published: 1 July 2016
..., as neighbouring cells physically interact with each other via lateral contacts and/or basal protrusions. Since Notch signalling controls cell division timing downstream of Cdc25, ECs in lateral contact with a Delta-expressing cell experience higher levels of Notch signalling and divide first, followed by more...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1325–1335.
Published: 1 April 2015
... Drosophila oogenesis. Cc2d1a Aki Tape Dpp Lgd [L(2)gd1] Notch signalling Endocytosis In recent years, it has been established that the tumour suppressor gene lethal (2) giant discs ( lgd ) [ l(2)gd1 – FlyBase] has a function in the endosomal pathway and in the regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4806–4816.
Published: 15 December 2014
... is a target of Notch signalling, whereas Dll1 is Wnt regulated. Regulation of Dll1 and Notch1 expression thus links the activity of Wnt and Notch, the two main signalling pathways driving the clock. We developed an algorithm that facilitates the identification of spatiotemporal expression patterns from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2014–2023.
Published: 15 May 2014
... dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate a new ISC and an enteroblast (EB) differentiating daughter. Notch signalling activity restricted to the EB regulates intestinal cell fate decision. Here, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2657–2668.
Published: 1 July 2013
... that centrosome movements are controlled by the cell fate determinant Numb, which does not act via its classical effectors, Sanpodo and α-Adaptin, but via the Collapsin Response Mediator Protein (CRMP). Furthermore, we find that CRMP is necessary for efficient Notch signalling and that it regulates the duration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 66–75.
Published: 1 January 2013
... activation of Notch signalling. Consistent with the interpretation that the combination of Notch and Wnt signalling maintains crypt cells in a low proliferative state, the treatment of β-catenin-expressing mice with a Notch inhibitor turned such slow-cycling cells into actively proliferating cells. Our...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3745–3757.
Published: 1 September 2011
... involved in MHB establishment. Here, we present evidence for a role for Notch signalling in stabilising cell lineage restriction and regulating organiser gene expression at the MHB. Experimental interference with Notch signalling in the chick embryo disrupts MHB formation, including downregulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2947–2956.
Published: 15 July 2011
... for a long-standing puzzle regarding the functions of the two Delta proteins in the somite segmentation clock – an explanation that is based on the proposition that they associate heterophilically to activate Notch. Notch signalling mediates communication between adjacent cells through the binding...
Journal Articles
Journal: Development
Development (2011) 138 (10): 1893–1902.
Published: 15 May 2011
... Hippo pathway Notch signalling Morphogen © 2011. 2011 23 2 2011 Competing interests statement The authors declare no competing financial interests. ‡ Authors for correspondence ( m.placzek@sheffield.ac.uk ; stuart.wilson@sheffield.ac.uk ) † Present address: Division...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 735–744.
Published: 15 February 2011
...Joana Neves; Carolina Parada; Mireia Chamizo; Fernando Giráldez Hair cells of the inner ear sensory organs originate from progenitor cells located at specific domains of the otic vesicle: the prosensory patches. Notch signalling is necessary for sensory development and loss of function of the Notch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3025–3035.
Published: 15 September 2010
...Thimios A. Mitsiadis; Daniel Graf; Hansueli Luder; Thomas Gridley; Gilles Bluteau The Notch signalling pathway is an evolutionarily conserved intercellular signalling mechanism that is essential for cell fate specification and proper embryonic development. We have analysed the expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2527–2537.
Published: 1 August 2010
... and structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (6): 913–922.
Published: 15 March 2010
... but their in vivo role is not clear. The sole Drosophila Gas2-like gene, CG3973 ( pigs ), was recently identified as a transcriptional target of Notch signalling and might therefore link cell fate decisions through Notch activation directly to morphogenetic changes. We have generated a null mutant in CG3973 ( pigs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2369–2378.
Published: 15 June 2007
...Nicolas Daudet; Linda Ariza-McNaughton; Julian Lewis Notch signalling is well-known to mediate lateral inhibition in inner ear sensory patches, so as to generate a balanced mixture of sensory hair cells and supporting cells. Recently, however, we have found that ectopic Notch activity at an early...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3391–3399.
Published: 15 July 2004
... of the embryo, and loss of cyclic gene expression in the presomitic mesoderm. Analysis of cyclic genes in RPTP ψ morphant embryos indicates an important requirement for RPTP ψ in the control of the somitogenesis clock upstream of or in parallel with Delta/Notch signalling. Impairing RPTPψ activity also...