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Keywords: Notch signalling
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Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (1): dev191437.
Published: 10 January 2021
... activation relies on the correct localization of the Notch signalling actors. We report that AP-1 and Stratum ensure the basolateral targeting of Notch during asymmetric cell division. Notch signalling Intracellular trafficking Asymmetric cell division Stratum AP-1 Cell-cell signalling...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (4): dev183665.
Published: 17 February 2020
.... Notch signalling regulates the balance between the rostral and caudal domains: high levels of Notch signalling expand the caudal domain at the expense of the rostral domain, whereas loss of Notch signalling produces the converse phenotype. Collectively, these data unravel a new patterning principle...
Includes: Supplementary data
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Neural development
Journal: Development
Development (2019) 146 (1): dev166595.
Published: 9 January 2019
... of Notch signalling disrupts the maintenance of this zone. When Notch is blocked, progenitor cells differentiate precociously, the proliferative ventricular zone is lost and differentiation markers become expressed throughout the spinal cord. Comparison with other chordates suggests that the emergence...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (24): 4701–4712.
Published: 15 December 2016
... Photoreceptor Notch signalling Atonal homolog 7 Fibroblast growth factor 3 Neurogenin 2 Summary: The pigeon retina bears striking structural and functional similarities to the primate macula. Neurogenesis in this system shows a delayed onset, and is uncoupled from tissue growth. © 2016...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2305–2310.
Published: 1 July 2016
..., as neighbouring cells physically interact with each other via lateral contacts and/or basal protrusions. Since Notch signalling controls cell division timing downstream of Cdc25, ECs in lateral contact with a Delta-expressing cell experience higher levels of Notch signalling and divide first, followed by more...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1325–1335.
Published: 1 April 2015
... Drosophila oogenesis. Cc2d1a Aki Tape Dpp Lgd [L(2)gd1] Notch signalling Endocytosis In recent years, it has been established that the tumour suppressor gene lethal (2) giant discs ( lgd ) [ l(2)gd1 – FlyBase] has a function in the endosomal pathway and in the regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4806–4816.
Published: 15 December 2014
... is a target of Notch signalling, whereas Dll1 is Wnt regulated. Regulation of Dll1 and Notch1 expression thus links the activity of Wnt and Notch, the two main signalling pathways driving the clock. References Agrawal , S. , Archer , C. and Schaffer , D. V. ( 2009 ). Computational models...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2014–2023.
Published: 15 May 2014
... dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate a new ISC and an enteroblast (EB) differentiating daughter. Notch signalling activity restricted to the EB regulates intestinal cell fate decision. Here, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2657–2668.
Published: 1 July 2013
... that centrosome movements are controlled by the cell fate determinant Numb, which does not act via its classical effectors, Sanpodo and α-Adaptin, but via the Collapsin Response Mediator Protein (CRMP). Furthermore, we find that CRMP is necessary for efficient Notch signalling and that it regulates the duration...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (17): 3745–3757.
Published: 1 September 2011
... involved in MHB establishment. Here, we present evidence for a role for Notch signalling in stabilising cell lineage restriction and regulating organiser gene expression at the MHB. Experimental interference with Notch signalling in the chick embryo disrupts MHB formation, including downregulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2947–2956.
Published: 15 July 2011
... ). Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta . Nature 375 , 761 - 766 . Crosnier C. , Vargesson N. , Gschmeissner S. , Ariza-McNaughton L. , Morrison A. , Lewis J. ( 2005 ). Delta-Notch signalling...
Journal Articles
Journal: Development
Development (2011) 138 (10): 1893–1902.
Published: 15 May 2011
... declare no competing financial interests. 23 2 2011 © 2011. 2011 Cadherin Neural tube Chick RNAi Screen FatJ Progenitor cells Interneurons Phenotype Hippo pathway Notch signalling Morphogen Neural progenitor cells are patterned along the dorsoventral axis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 735–744.
Published: 15 February 2011
...Joana Neves; Carolina Parada; Mireia Chamizo; Fernando Giráldez Hair cells of the inner ear sensory organs originate from progenitor cells located at specific domains of the otic vesicle: the prosensory patches. Notch signalling is necessary for sensory development and loss of function of the Notch...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2010) 137 (6): 913–922.
Published: 15 March 2010
... but their in vivo role is not clear. The sole Drosophila Gas2-like gene, CG3973 ( pigs ), was recently identified as a transcriptional target of Notch signalling and might therefore link cell fate decisions through Notch activation directly to morphogenetic changes. We have generated a null mutant in CG3973 ( pigs...
Includes: Supplementary data
Journal Articles