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Keywords: Notch
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Journal Articles
Journal: Development
Development dev.199928.
Published: 10 January 2022
... in central regions of foetal muscles. We also identified a similar regionalization for the NOTCH ligand JAGGED2 along with an absence of NOTCH activity in TMEM8C + fusion-competent myocytes. NOTCH function in myoblast fusion had not been addressed so far. We analysed the consequences of NOTCH inhibition...
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199630.
Published: 22 November 2021
... pERK and may promote Notch signaling in pFCs. In a JNK-independent manner, ben downregulates Hh signaling in pFCs. Schematics depict signaling pathway activity profiles in region 2a (2a), FSCs, Region 2b (2b), region 3 (3), polar (P) and stalk (S) cells in the FSC lineage. In schematics for each...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199940.
Published: 10 November 2021
... poorly understood. Here, we identify a regulatory pathway that controls alveolar progenitor differentiation and lactation by governing Notch activation in mouse. Loss of Robo1 in the mammary gland epithelium activates Notch signaling, which expands the alveolar progenitor cell population at the expense...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199831.
Published: 14 October 2021
...Julia Falo-Sanjuan; Sarah J. Bray ABSTRACT The Notch pathway mediates cell-to-cell communication in a variety of tissues, developmental stages and organisms. Pathway activation relies on the interaction between transmembrane ligands and receptors on adjacent cells. As such, pathway activity could...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev196345.
Published: 02 August 2021
... in the nematode Caenorhabditis elegans is regulated by conserved Notch signaling. Here, we reveal that the exocyst complex regulates C. elegans GSC proliferation by modulating Notch signaling cell autonomously. Notch membrane density is asymmetrically maintained on GSCs. Knockdown of exocyst complex subunits...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev197301.
Published: 17 May 2021
... predicts an adhesion-dominant intercalation mechanism. Genetic experiments support this prediction, revealing a role for adhesion through the Nephrin proteins Roughest and Hibris. Second, we found that cone cell intercalation is regulated by the Notch pathway. Third, we show that endocytosis is required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev189191.
Published: 17 February 2021
...Toshiyuki Ohtsuka; Ryoichiro Kageyama ABSTRACT Neural stem cells (NSCs) gradually alter their characteristics during mammalian neocortical development, resulting in the production of various neurons and glial cells, and remain in the postnatal brain as a source of adult neurogenesis. Notch-Hes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev192203.
Published: 07 October 2020
...-positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in DN4 and DP cells is oncogenic. Here, we show that pre-TCR signalling leads to increased expression of the transcriptional repressor Bcl6...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev193482.
Published: 28 September 2020
...Katherine Leisan Luo; Ryan S. Underwood; Iva Greenwald ABSTRACT During animal development, ligand binding releases the intracellular domain of LIN-12/Notch by proteolytic cleavage to translocate to the nucleus, where it associates with the DNA-binding protein LAG-1/CSL to activate target gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev162263.
Published: 22 June 2020
... and patterning. Atoh1 Deafness Hearing Notch Organ of Corti Radial intercalation Several studies have demonstrated similar levels of plasticity in cells within the cochlear roof. Overexpression of Atoh1 , Sox2 or activated Notch1 induces ectopic regions of HCs and SCs in Reissner's...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178988.
Published: 22 June 2020
... of self-tolerance, but the mechanisms controlling their fetal specification and differentiation are poorly understood. Here, we show that notch signaling is required to specify and expand the mTEC lineage. Notch1 is expressed by and active in TEC progenitors. Deletion of Notch1 in TECs resulted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev181024.
Published: 27 August 2019
... by the identity of the approaching secondary sprout emerging from the posterior cardinal vein. Here, we show that the formation of a balanced trunk vasculature involves an early heterogeneity in endothelial cell behaviour and Notch signalling activity in the seemingly identical primary ISVs that is independent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev170241.
Published: 02 August 2019
... at the boundary between tendon and bone by regulating cell fate decisions through a mechanism that employs Notch signaling. All μCT scans were performed by the University of Southern California Molecular Imaging Center using a μCT50 (Scanco Medical). Samples were rotated 360° and X-ray settings were...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev170837.
Published: 24 July 2019
...Ankita Singh; Maimuna S. Paul; Debdeep Dutta; Mousumi Mutsuddi; Ashim Mukherjee ABSTRACT Notch signaling plays a pleiotropic role in a variety of cellular processes, including cell fate determination, differentiation, proliferation and apoptosis. The increasingly complex regulatory mechanisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev173195.
Published: 23 April 2019
... number, we analyzed the Notch signaling pathway. The Notch effectors LST-1 and SYGL-1 displayed age-related decreases in expression domains, suggesting a role for Notch signaling in germline aging. The results indicate that although sporadic defects account for the sterility of some animals, population...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev163618.
Published: 20 February 2019
... The undifferentiated state of muscle stem (satellite) cells (MuSCs) is maintained by the canonical Notch pathway. Although three bHLH transcriptional factors, Hey1, HeyL and Hes1, are considered to be potential effectors of the Notch pathway exerting anti-myogenic effects, neither HeyL nor Hes1 inhibits myogenic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev172510.
Published: 20 February 2019
... - and gata3 -dependent precursors co-expressing markers of V2b and V2s interneurons. Chemical blockage of Notch signalling causes a decrease in V2s and an increase in V2b cells. Our results are consistent with the existence of at least two types of precursor arranged in a hierarchical manner in the V2 domain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev172148.
Published: 01 February 2019
...Domingos Henrique; François Schweisguth ABSTRACT Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch receptors relay information from the cell surface to the genome via a very simple mechanism, yet Notch plays multiple roles...
Journal Articles
Journal: Development
Development (2019) 146 (2): dev165589.
Published: 25 January 2019
.... The emergence of peri-arterial pdgfrb high MCs required Notch signaling. We found that pdgfrb -positive cells express notch2 in addition to notch3 , and although depletion of notch2 or notch3 failed to block MC emergence, embryos depleted of both notch2 and notch3 lost mesoderm- as well as neural crest-derived...
Includes: Supplementary data