... signalling pathway factors either activating or inhibiting the pathway. For example, increased cytoplasmic Ca 2+ due to lack of buffering capacity by fragmented mitochondria in Opa1- and Mfn1-depleted cardiomyocytes increases calcineurin activation and Notch processing, thereby activating the Notch...

... WNT Notch hiPSC Neurogenetic niche Cell transplantation Zbtb20 Laminin 511 European Commission http://dx.doi.org/10.13039/501100000780 603191 H2020 LEIT Information and Communication Technologies http://dx.doi.org/10.13039/100010669 732678 Although...

...Yan Li; Chao Tang; Fan Liu; Caiying Zhu; Feng Liu; Ping Zhu; Lu Wang ABSTRACT The earliest hematopoietic stem and progenitor cells (HSPCs) are generated from the ventral wall of the dorsal aorta, through endothelial-to-hematopoietic transition during vertebrate embryogenesis. Notch signaling...

...Kathryn Duvall; Lauren Crist; Alison J. Perl; Naomi Pode Shakked; Praneet Chaturvedi; Raphael Kopan ABSTRACT Notch signaling promotes maturation of nephron epithelia, but its proposed contribution to nephron segmentation into proximal and distal domains has been called into doubt. We leveraged...

...Yukino Wada; Hikaru Tsukatani; Chihiro Kuroda; Yurika Miyazaki; Miku Otoshi; Isao Kobayashi ABSTRACT During development, the somites play a key role in the specification of hematopoietic stem cells (HSCs). In zebrafish, the somitic Notch ligands Delta-c (Dlc) and Dld, both of which are regulated...

... whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed...

... regionalized in central regions of foetal muscles. We also identified a similar regionalization for the gene encoding the NOTCH ligand JAG2 along with an absence of NOTCH activity in TMEM8C + fusion-competent myocytes. NOTCH function in myoblast fusion had not been addressed so far. We analysed...

... Assa-Kunik , E. , Torres , I. L. , Schejter , E. D. , Johnston , D. S. and Shilo , B.-Z. ( 2007 ). Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways . Development 134 , 1161 - 1169 . 10.1242...

... poorly understood. Here, we identify a regulatory pathway that controls alveolar progenitor differentiation and lactation by governing Notch activation in mouse. Loss of Robo1 in the mammary gland epithelium activates Notch signaling, which expands the alveolar progenitor cell population at the expense...

...Julia Falo-Sanjuan; Sarah J. Bray ABSTRACT The Notch pathway mediates cell-to-cell communication in a variety of tissues, developmental stages and organisms. Pathway activation relies on the interaction between transmembrane ligands and receptors on adjacent cells. As such, pathway activity could...

... in the nematode Caenorhabditis elegans is regulated by conserved Notch signaling. Here, we reveal that the exocyst complex regulates C. elegans GSC proliferation by modulating Notch signaling cell autonomously. Notch membrane density is asymmetrically maintained on GSCs. Knockdown of exocyst complex subunits...

... predicts an adhesion-dominant intercalation mechanism. Genetic experiments support this prediction, revealing a role for adhesion through the Nephrin proteins Roughest and Hibris. Second, we found that cone cell intercalation is regulated by the Notch pathway. Third, we show that endocytosis is required...

...Toshiyuki Ohtsuka; Ryoichiro Kageyama ABSTRACT Neural stem cells (NSCs) gradually alter their characteristics during mammalian neocortical development, resulting in the production of various neurons and glial cells, and remain in the postnatal brain as a source of adult neurogenesis. Notch-Hes...

...-positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in DN4 and DP cells is oncogenic. Here, we show that pre-TCR signalling leads to increased expression of the transcriptional repressor Bcl6...

...Katherine Leisan Luo; Ryan S. Underwood; Iva Greenwald ABSTRACT During animal development, ligand binding releases the intracellular domain of LIN-12/Notch by proteolytic cleavage to translocate to the nucleus, where it associates with the DNA-binding protein LAG-1/CSL to activate target gene...

... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...

... of cochlear formation including cell fate, outgrowth and patterning. Atoh1 Deafness Hearing Notch Organ of Corti Radial intercalation The mammalian inner ear is a remarkable structure, made up of a labyrinth of elaborate ducts and canals ( Fig. 1 ). Together, these facilitate the perception...

... of self-tolerance, but the mechanisms controlling their fetal specification and differentiation are poorly understood. Here, we show that notch signaling is required to specify and expand the mTEC lineage. Notch1 is expressed by and active in TEC progenitors. Deletion of Notch1 in TECs resulted...

... by the identity of the approaching secondary sprout emerging from the posterior cardinal vein. Here, we show that the formation of a balanced trunk vasculature involves an early heterogeneity in endothelial cell behaviour and Notch signalling activity in the seemingly identical primary ISVs that is independent...

... at the boundary between tendon and bone by regulating cell fate decisions through a mechanism that employs Notch signaling. Fig. 9. Loss of Fgfr2 alters expression of Notch pathway members at the tendon-bone interface. (A) In control at E16.5, Notch2 is high in the angular cartilage (dashed line...