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Keywords: Notch
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Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (11): dev201785.
Published: 8 June 2023
...Jonathan M. Townson; Maria J. Gomez-Lamarca; Carmen Santa Cruz Mateos; Sarah J. Bray ABSTRACT Active Notch signalling is elicited through receptor–ligand interactions that result in release of the Notch intracellular domain (NICD), which translocates into the nucleus. NICD activates transcription...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (11): dev201297.
Published: 1 June 2023
...Tao He; Yu Fan; Juan Du; Mengyuan Yi; Yajuan Li; Min Liu; Alan Jian Zhu ABSTRACT Evolutionarily conserved Notch signaling is highly sensitive to changes in Notch receptor dose caused by intrinsic and environmental fluctuations. It is well known that epigenetic regulation responds dynamically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (7): dev201030.
Published: 11 April 2023
... endothelial growth factor (Vegf), Notch and cxcr4a signalling. Subsequently, veins produced veins in more proximal fin regions, transforming pre-existing artery-vein loops into a three-vessel pattern consisting of an artery and two veins. A distinct set of vascular plexuses formed at the base of the fin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (4): dev201138.
Published: 16 February 2023
...Oren Gozlan; David Sprinzak ABSTRACT Notch signaling is a highly conserved signaling pathway that coordinates cellular differentiation during the development and homeostasis in numerous organs and tissues across metazoans. Activation of Notch signaling relies on direct contact between neighboring...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (23): dev200870.
Published: 29 November 2022
... Drosophila and vertebrates on how mitochondrial respiration and morphology interact with neural stem cell transitions in the developing and adult brain in vivo . Neural stem cell Mitochondria Oxidative phosphorylation Mitochondrial morphology Reactive oxygen species Notch Wellcome http...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200339.
Published: 7 April 2022
...Yukino Wada; Hikaru Tsukatani; Chihiro Kuroda; Yurika Miyazaki; Miku Otoshi; Isao Kobayashi ABSTRACT During development, the somites play a key role in the specification of hematopoietic stem cells (HSCs). In zebrafish, the somitic Notch ligands Delta-c (Dlc) and Dld, both of which are regulated...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199928.
Published: 25 January 2022
... regionalized in central regions of foetal muscles. We also identified a similar regionalization for the gene encoding the NOTCH ligand JAG2 along with an absence of NOTCH activity in TMEM8C + fusion-competent myocytes. NOTCH function in myoblast fusion had not been addressed so far. We analysed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199630.
Published: 22 November 2021
... cells are specified by JAK-STAT signaling from polar cells, and differentiation toward the polar cell fate is induced in early pFCs by Notch signaling ( Assa-Kunik et al., 2007 ; Dai et al., 2017 ; Lopez-Schier and St Johnston, 2001 ). Therefore, we next investigated whether a loss of JNK signaling...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199831.
Published: 14 October 2021
...Julia Falo-Sanjuan; Sarah J. Bray ABSTRACT The Notch pathway mediates cell-to-cell communication in a variety of tissues, developmental stages and organisms. Pathway activation relies on the interaction between transmembrane ligands and receptors on adjacent cells. As such, pathway activity could...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev196345.
Published: 2 August 2021
... in the nematode Caenorhabditis elegans is regulated by conserved Notch signaling. Here, we reveal that the exocyst complex regulates C. elegans GSC proliferation by modulating Notch signaling cell autonomously. Notch membrane density is asymmetrically maintained on GSCs. Knockdown of exocyst complex subunits...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (4): dev189191.
Published: 17 February 2021
...Toshiyuki Ohtsuka; Ryoichiro Kageyama ABSTRACT Neural stem cells (NSCs) gradually alter their characteristics during mammalian neocortical development, resulting in the production of various neurons and glial cells, and remain in the postnatal brain as a source of adult neurogenesis. Notch-Hes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev192203.
Published: 7 October 2020
...-positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in DN4 and DP cells is oncogenic. Here, we show that pre-TCR signalling leads to increased expression of the transcriptional repressor Bcl6...
Includes: Supplementary data