...Tao He; Yu Fan; Juan Du; Mengyuan Yi; Yajuan Li; Min Liu; Alan Jian Zhu ABSTRACT Evolutionarily conserved Notch signaling is highly sensitive to changes in Notch receptor dose caused by intrinsic and environmental fluctuations. It is well known that epigenetic regulation responds dynamically...

...Jonathan M. Townson; Maria J. Gomez-Lamarca; Carmen Santa Cruz Mateos; Sarah J. Bray Active Notch signalling is elicited through receptor-ligand interactions that result in release of the Notch intracellular domain (NICD), which translocates into the nucleus. NICD activates transcription at target...

.... The Notch signaling pathway plays crucial roles during this process but the molecular mechanisms by which Notch impacts progenitor fate decisions have not been fully resolved. Here, we show that Notch signaling is essential for neocortical and hippocampal morphogenesis, and for the development of the corpus...

... endothelial growth factor (Vegf), Notch and cxcr4a signalling. Subsequently, veins produced veins in more proximal fin regions, transforming pre-existing artery-vein loops into a three-vessel pattern consisting of an artery and two veins. A distinct set of vascular plexuses formed at the base of the fin...

...Oren Gozlan; David Sprinzak ABSTRACT Notch signaling is a highly conserved signaling pathway that coordinates cellular differentiation during the development and homeostasis in numerous organs and tissues across metazoans. Activation of Notch signaling relies on direct contact between neighboring...

... Drosophila and vertebrates on how mitochondrial respiration and morphology interact with neural stem cell transitions in the developing and adult brain in vivo . Neural stem cell Mitochondria Oxidative phosphorylation Mitochondrial morphology Reactive oxygen species Notch Wellcome http...

... WNT Notch hiPSC Neurogenetic niche Cell transplantation Zbtb20 Laminin 511 European Commission http://dx.doi.org/10.13039/501100000780 603191 H2020 LEIT Information and Communication Technologies http://dx.doi.org/10.13039/100010669 732678 Although...

...Yan Li; Chao Tang; Fan Liu; Caiying Zhu; Feng Liu; Ping Zhu; Lu Wang ABSTRACT The earliest hematopoietic stem and progenitor cells (HSPCs) are generated from the ventral wall of the dorsal aorta, through endothelial-to-hematopoietic transition during vertebrate embryogenesis. Notch signaling...

...Kathryn Duvall; Lauren Crist; Alison J. Perl; Naomi Pode Shakked; Praneet Chaturvedi; Raphael Kopan ABSTRACT Notch signaling promotes maturation of nephron epithelia, but its proposed contribution to nephron segmentation into proximal and distal domains has been called into doubt. We leveraged...

...Yukino Wada; Hikaru Tsukatani; Chihiro Kuroda; Yurika Miyazaki; Miku Otoshi; Isao Kobayashi ABSTRACT During development, the somites play a key role in the specification of hematopoietic stem cells (HSCs). In zebrafish, the somitic Notch ligands Delta-c (Dlc) and Dld, both of which are regulated...

... whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed...

... regionalized in central regions of foetal muscles. We also identified a similar regionalization for the gene encoding the NOTCH ligand JAG2 along with an absence of NOTCH activity in TMEM8C + fusion-competent myocytes. NOTCH function in myoblast fusion had not been addressed so far. We analysed...

... cells are specified by JAK-STAT signaling from polar cells, and differentiation toward the polar cell fate is induced in early pFCs by Notch signaling ( Assa-Kunik et al., 2007 ; Dai et al., 2017 ; Lopez-Schier and St Johnston, 2001 ). Therefore, we next investigated whether a loss of JNK signaling...

... poorly understood. Here, we identify a regulatory pathway that controls alveolar progenitor differentiation and lactation by governing Notch activation in mouse. Loss of Robo1 in the mammary gland epithelium activates Notch signaling, which expands the alveolar progenitor cell population at the expense...

...Julia Falo-Sanjuan; Sarah J. Bray ABSTRACT The Notch pathway mediates cell-to-cell communication in a variety of tissues, developmental stages and organisms. Pathway activation relies on the interaction between transmembrane ligands and receptors on adjacent cells. As such, pathway activity could...

... in the nematode Caenorhabditis elegans is regulated by conserved Notch signaling. Here, we reveal that the exocyst complex regulates C. elegans GSC proliferation by modulating Notch signaling cell autonomously. Notch membrane density is asymmetrically maintained on GSCs. Knockdown of exocyst complex subunits...

... predicts an adhesion-dominant intercalation mechanism. Genetic experiments support this prediction, revealing a role for adhesion through the Nephrin proteins Roughest and Hibris. Second, we found that cone cell intercalation is regulated by the Notch pathway. Third, we show that endocytosis is required...

...Toshiyuki Ohtsuka; Ryoichiro Kageyama ABSTRACT Neural stem cells (NSCs) gradually alter their characteristics during mammalian neocortical development, resulting in the production of various neurons and glial cells, and remain in the postnatal brain as a source of adult neurogenesis. Notch-Hes...

...-positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in DN4 and DP cells is oncogenic. Here, we show that pre-TCR signalling leads to increased expression of the transcriptional repressor Bcl6...

...Katherine Leisan Luo; Ryan S. Underwood; Iva Greenwald ABSTRACT During animal development, ligand binding releases the intracellular domain of LIN-12/Notch by proteolytic cleavage to translocate to the nucleus, where it associates with the DNA-binding protein LAG-1/CSL to activate target gene...