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Keywords: Node
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (6): dev199999.
Published: 28 March 2022
... portion precursor map in anterior epiblasts at st. 4/5. Grafting outside the brain precursor region of mCherry-expressing nodes producing anterior mesendoderm (AME) or isolated AME tissues elicited new cell migration towards ectopic AME tissues. These locally convergent cells developed into secondary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 3915–3920.
Published: 15 September 2011
...Yoshihiro Komatsu; Vesa Kaartinen; Yuji Mishina Cilia at the node generate a leftward fluid flow that breaks left-right symmetry. However, the molecular mechanisms that regulate ciliogenesis at the node are largely unknown. Here, we show that the epiblast-specific deletion of the gene encoding...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (23): 3917–3925.
Published: 1 December 2009
...Shinya Oki; Keiko Kitajima; Sara Marques; José António Belo; Takahiko Yokoyama; Hiroshi Hamada; Chikara Meno The node at the anterior tip of the primitive streak serves as an initial generator of the left-right (L-R) axis in mammalian embryos. We now show that a small disturbance in molecular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (24): 4381–4393.
Published: 15 December 2007
... of e-cadherin , thereby perturbing cell movements during convergent extension, epiboly and node formation. Thus, although the role of Smad proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3893–3904.
Published: 1 November 2007
...Shinya Oki; Ryuju Hashimoto; Yuko Okui; Michael M. Shen; Eisuke Mekada; Hiroki Otani; Yukio Saijoh; Hiroshi Hamada Situs-specific organogenesis in the mouse results from leftward fluid flow in the node cavity and subsequent left-sided expression of Nodal in the lateral plate mesoderm (LPM). Nodal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (15): 2829–2840.
Published: 1 August 2007
..., the chordoneural hinge, but the localisation of such progenitors at earlier stages is so far untested. By studying gene expression, we have shown that a specific topological arrangement of domains persists from the streak to the tail bud, and includes an area (the node-streak border) in which ectoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (2): 297–306.
Published: 15 January 2006
... regulated by the coordination of five phylogenetically conserved enhancers having discrete regional coverage, among which the 420-bp long enhancer N-1, active in the node-proximal region, is probably involved directly in the genesis of the posterior neural plate. We investigated the signaling systems...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (21): 4719–4729.
Published: 1 November 2005
...Atsushi Sawada; Yuriko Nishizaki; Hiroko Sato; Yukari Yada; Rika Nakayama; Shinji Yamamoto; Noriyuki Nishioka; Hisato Kondoh; Hiroshi Sasaki The cell population and the activity of the organizer change during the course of development. We addressed the mechanism of mouse node development via...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (2): 263–274.
Published: 15 January 2004
... requirement for a repressor function of Lef/Tcf proteins during early mouse development. Tcf3 -/- embryos proceed through gastrulation to form mesoderm, but they develop expanded and often duplicated axial mesoderm structures, including nodes and notochords. These duplications are preceded by ectopic...
Journal Articles
Journal: Development
Development (2003) 130 (16): 3891–3902.
Published: 15 August 2003
... was required for repression in regions of the CNS where Shh is not normally expressed. We further show that Shh enhancer activity was detected in the mouse node from where the floor plate and notochord precursors derive. Shh reporter expression was restricted to the ventral (mesodermal)layer of the node...
Journal Articles
Journal: Development
Development (2003) 130 (9): 1725–1734.
Published: 1 May 2003
... that the fusion protein is functional. In transgenic embryos, Inv::GFP protein was detected in the node monocilia. The fusion protein was also present in other 9+0 monocilia,including those of kidney epithelial cells and the pituitary gland, but it was not localized to 9+2 cilia. The N-terminal region of Inv...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (20): 4685–4696.
Published: 15 October 2002
...Takeshi Fujiwara; Deborah B. Dehart; Kathleen K. Sulik; Brigid L. M. Hogan In the mouse and chick embryo, the node plays a central role in generating left-right (LR) positional information. Using several different strategies, we provide evidence in the mouse that bone morphogenetic protein 4 (Bmp4...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3597–3608.
Published: 1 August 2002
... Homeobox Gastrulation Mesendoderm Notochord Node Endoderm Mouse In Xenopus, members of the Mix/Bix family of Paired -like homeobox genes have been implicated as regulators of gastrulation. Mix.1 , the founding member of this family, was originally identified as an immediate-early response...
Journal Articles
Journal: Development
Development (2001) 128 (18): 3623–3634.
Published: 15 September 2001
... , and the ability of these cells to induce a second neural axis in the host embryo. This cell population can therefore be regarded as the mid-gastrula organizer and, together with the early-gastrula organizer and the node, constitute the organizer of the mouse embryo at successive stages of development. The profile...