... that the original work is properly attributed. Summary: Expression of the mouse T-box factor Eomes is controlled by a key gene-proximal enhancer-like element, with changes in chromatin accessibility influencing its activity in definitive endoderm. Eomesodermin Enhancer Capture-C Nodal signalling...

... NOTCH activation results in misregulation of NODAL signalling, a major determinant of early embryonic patterning. Our study reveals a previously unidentified role for canonical NOTCH signalling during mammalian gastrulation. It also exemplifies how in vivo studies can shed light on the mechanisms...

... proliferation along the A-P axis of the mouse embryo. Rather, we have identified that as AVE movements are being initiated, the epiblast proliferates at a much higher rate than the visceral endoderm. We show that these high levels of proliferation in the epiblast are dependent on Nodal signalling...

...Steven A. Harvey; Stefan Tümpel; Julien Dubrulle; Alexander F. Schier; James C. Smith During early zebrafish development the nodal signalling pathway patterns the embryo into three germ layers, in part by inducing the expression of no tail ( ntl ), which is essential for correct mesoderm formation...

... and axonal projections. The elaboration of habenular asymmetries requires the presence of a second asymmetric structure, the parapineal, the laterality of which is biased by unilateral Nodal signalling. Here we show that neurons are present earlier in the left habenula than in the right, but,in contrast...

...-mail: josh.brickman@ed.ac.uk ) * Present address: Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA 3 7 2006 © 2006. 2006 Endoderm Mesendoderm Hex Hhex PRH Anterior Wnt signalling Nodal signalling Organiser...

... allele in temperature shift-up and shift-down experiments to answer a central question pertaining to the timing of vertebrate floor plate induction. Abrogation of Cyc/Nodal signalling in the temperature-sensitive mutant embryos at various stages indicates that the floor plate in zebrafish is induced...

...Morgane Poulain; Thierry Lepage Endoderm specification in zebrafish is mediated by the zygotic transcription factors Bon/Mixer, Faust/Gata5, Casanova and Sox17, whose expression is induced by Nodal signalling. Bon/Mixer and Gata5 require Casanova in order to promote endoderm formation and all three...

...). While this study has helped to define the structure-function relationships between Cripto and nodal signalling, future studies based on these findings will provide new insight in the molecular basis of signal transduction controlled by EGF-CFC proteins. Furthermore, the generation of mouse models...