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Keywords: Nkx6.2
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Journal Articles
Journal: Development
Development (2007) 134 (13): 2491–2500.
Published: 1 July 2007
... address the mechanism by which the transcription factors Nkx6.1 (Nkx6-1) and Nkx6.2 (Nkx6-2) orchestrate development of the endocrine alpha- and beta-cell lineages. Specifically, we assayed for the rescue of insulin-producing beta-cells in Nkx6.1 mutant mice upon restoring Nkx6 activity in select...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (13): 3139–3149.
Published: 1 July 2005
... other islet cell types develop normally. However, the molecular events downstream of NKX6.1, as well as the molecular pathways that ensure residualβ-cell formation in the absence of NKX6.1 are largely unknown. Here, we show that the Nkx6.1 paralog, Nkx6.2 , is expressed during pancreas development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (23): 5815–5826.
Published: 1 December 2003
.... Indirect immunofluorescence analyses were performed on cryosections as described previously ( Briscoe et al.,2000 ). The following primary antibodies were used: rabbit anti-Nkx6.1 ( Jensen et al.,1996 ); guinea pig anti-Nkx6.2 and mouse anti-Evx1( Vallstedt et al., 2001 );mouse anti-Islet1, mouse anti-2H3...