..., these observations could be explained by a requirement of Notch for the expression of the trunk determination gene Nkx6.1 . This was supported by the finding of direct binding of RBP-jκ to the Nkx6.1 proximal promoter. References Afelik S. , Chen Y. L. , Pieler T. ( 2006 ). Combined ectopic...

... address the mechanism by which the transcription factors Nkx6.1 (Nkx6-1) and Nkx6.2 (Nkx6-2) orchestrate development of the endocrine alpha- and beta-cell lineages. Specifically, we assayed for the rescue of insulin-producing beta-cells in Nkx6.1 mutant mice upon restoring Nkx6 activity in select...

...-producing cells in vitro could constitute a cure for diabetes, recent studies have explored the molecular program that underlies β-cell formation. From these studies, the homeodomain transcription factor NKX6.1 has proven to be a key player. In Nkx6.1 mutants, β-cell numbers are selectively reduced, while...

... program during CNS development. We have investigated the significance of these similar expression patterns by testing whether Nkx6 proteins expressed in ventral CNS of zebrafish and flies have similar functions. In zebrafish, Nkx6.1 is expressed in early-born primary and later-born secondary motoneurons...

... factor Nkx6.1 is required for the early specification of somatic motoneuron progenitors in the spinal cord. Our present analysis of hindbrain motoneuron development in Nkx6.1-deficient mouse embryos reveals that the early specification of branchio-motoneurons is independent of Nkx6.1 function...