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Keywords: Ngn3
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Journal Articles
Journal: Development
Development (2015) 142 (5): 871–882.
Published: 1 March 2015
.... Strikingly, inactivation of Hnf1b at different time points results in the absence of Ngn3 + endocrine precursors throughout embryogenesis. We further show that Hnf1b occupies novel Ngn3 putative regulatory sequences in vivo . Thus, Hnf1b plays a crucial role in the regulatory networks that control pancreatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2488–2499.
Published: 15 July 2012
... competent to differentiate into ductal and endocrine cells by inducing activators of cell differentiation. Notch signaling promotes the expression of Sox9, which cell-autonomously activates the pro-endocrine gene Ngn3 . However, at high Notch activity endocrine differentiation is blocked, as Notch also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2491–2500.
Published: 1 July 2007
... progenitor cell populations with different Nkx6 -expressing transgenes. Beta-cell formation and maturation was restored when Nkx6.1 was expressed in multipotential Pdx1 + pancreatic progenitors, whereas no rescue was observed upon expression in committed Ngn3 + (Neurog3 + ) endocrine progenitors. Although...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1495–1505.
Published: 15 April 2006
... cells, the undifferentiated spermatogonia. However, the relationship between the establishment of this population and the initiation of differentiation in the developing testes remains unclear. In this study, we have investigated this issue by using the unique expression of Ngn3, which is expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (10): 2447–2457.
Published: 15 May 2002
... the progeny of cells expressing either Ngn3 or Pdx1 at different stages of development. The results provide direct evidence that NGN3+ cells are islet progenitors during embryogenesis and in adult mice. In addition, we find that cells expressing Pdx1 give rise to all three types of pancreatic tissue: exocrine...