... in the formation of V1R + /apical and V2R + /basal vomeronasal sensory neurons of rodents. Single cell RNA sequencing Vomeronasal organ Notch signaling Dll4 Neuronal dichotomy Mouse Neuronal differentiation Eunice Kennedy Shriver National Institute of Child Health and Human Development http...

.... C. elegans Lineage Neuronal differentiation Transcriptional control The complete lineage map of every individual cell in the nematode Caenorhabditis elegans provides an excellent opportunity to study how lineage affects cellular identity ( Sulston and Horvitz, 1977 ; Sulston et al...

... and neuronal differentiation . Development   130 , 3781 - 3794 . 10.1242/dev.00571 Dasen , J. S. , Liu , J.-P. and Jessell , T. M. ( 2003 ). Motor neuron columnar fate imposed by sequential phases of Hox-c activity . Nature   425 , 926 - 933 . 10.1038/nature02051 Dasen , J...

...-neural TF that represses dacapo . In addition to its effects on Asense and Prospero, Mnb also promotes the expression of the neuronal-specific RNA regulator Elav, strongly suggesting that Mnb facilitates neuronal differentiation. These actions of Mnb ensure the precise timing of neuronal birth, coupling...

...) in the zebrafish hindbrain. Delays in differentiation are reduced by knocking down N-cadherin, a manipulation expected to help destabilize adherens junctions (AJs). This suggested that delays in neuronal differentiation in epb41l5 -deficient embryos are related to a previously described role for Epb41l5...

... the developmental timing of this transition have not been fully elucidated, gradual elongation in the length of the cell cycle and coinciding accumulation of determinants that promote neuronal differentiation might function as a biological clock that regulates the onset of asymmetric division and neurogenesis. We...

... Competing interests statement The authors declare no competing financial interests. 15 3 2012 © 2012. GABAergic Mouse knockout Rp58 (Znf238, Zfp238) Cerebellum hypoplasia Glutamatergic Granule neuron progenitors Neuronal differentiation The structure...

...Christopher Hindley; Fahad Ali; Gary McDowell; Kevin Cheng; Alison Jones; Francois Guillemot; Anna Philpott Neurogenin 2 (Ngn2) controls neuronal differentiation cell-autonomously by transcriptional activation of targets such as NeuroD , while simultaneously controlling progenitor maintenance non...

... ) or undetectable ( Grpr , galanin) in mutants ( Fig. 2G-J ; data not shown), suggesting that neurons within the superficial dorsal horn require Bcl11a for terminal differentiation. Fig. 2. Analysis of neuronal differentiation in the Bcl11a mutant dorsal spinal cord. ( A-F ) Immunohistological analysis...

... that occurs as development progresses. However, the mechanistic basis of this regulation is unknown. The proneural transcription factor Neurogenin 2 (Ngn2) acts as a master regulator of neuronal differentiation. Here, we demonstrate that Ngn2 is phosphorylated on multiple serine-proline sites in response...

... of the NOTCH intracellular domain (NICD), stimulated Delta1 expression and was required for the neuronal differentiation induced by the decrease in NOTCH signaling. Nevertheless, although Mnb/Dyrk1a GoF led to extensive withdrawal of neuronal precursors from the cell cycle, it was insufficient to elicit...

... nuclei. Similarly, maintenance of noradrenergic differentiation during embryogenesis requires ongoing expression of Phox2b in sympathetic ganglia, and of Phox2a in the main noradrenergic center, the locus coeruleus. These data illustrate cases where the neuronal differentiation program does not unfold...

... on retinoblast cell cycle kinetics: id2a -overexpressing retinoblasts progress from S to M phase more rapidly and they undergo mitosis more frequently, which results in macrophthalmia. Mosaic analyses reveal that Id2a function in facilitating both cell cycle progression and neuronal differentiation in the retina...

... migrating NCCs mainly constituting melanocytic progenitors specifically require Wnt3a. Delamination of these cells involves a mechanism other than one that depends on Bmp4-Wnt1 signaling. The nature of the signals controlling neuronal differentiation has been more difficult to identify. Our results...

... and their respective signaling machineries, by acting in a dynamic, but strictly coordinated, spatiotemporal fashion, play a decisive role in determining hippocampal cell fate by inhibiting cell proliferation and promoting neuronal differentiation. We have also shown that BDNF, better known for TRK receptor-mediated...

... for Parkinson’s disease. * Author for correspondence (e-mail: horst.simon@urz.uni-heidelberg.de ) 17 2 2004 © 2004. 2004 Transcription factors Ventral tegmentum Neurodegenerative disease Neuronal survival Neuronal differentiation The pathological hallmark of Parkinson’s...

... neuronal cell type in Cnidaria. The molecular regulation of neuronal differentiation in Hydra is largely unknown. So far, only one of the genes involved in bilaterian neurogenesis has been isolated from Hydra , the bHLH transcription factor gene achaete-scute homolog Cnash ( Grens et al., 1995...

... positioning along the neurogenic cascade. During neurogenesis, cell cycle exit appears to be tightly coupled to migration to the mantle layer and to neuronal differentiation. We show that antagonizing Ebf gene activity allows the uncoupling of these processes. Ebf gene function is necessary to initiate...

... in Tcfap2a mutant mice prevented adequate assessment of the Tcfap2a mutant phenotype during neuronal differentiation. Thus, a potential role of Tfap2a during NA differentiation in vivo has not been previously investigated. We show that mutations isolated as mont blanc alleles[ mob ( Neuhauss et al...

... constitute the sm neurons of the abducens nucleus, while a smaller percentage represents the vm neurons of the superior salivatory nucleus. To test if the reduced Isl1 signal in r5 results from a defect in sm neuron differentiation, we examined the expression of the sm neuron marker Isl2 . At E10.5, Isl2...