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Keywords: Neuromesodermal progenitors
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Journal Articles
Journal: Development
Development (2021) 148 (11): dev199408.
Published: 1 June 2021
...Zhi Ye; Christopher R. Braden; Andrea Wills; David Kimelman ABSTRACT During early embryogenesis, the vertebrate embryo extends from anterior to posterior because of the progressive addition of cells from a posteriorly localized neuromesodermal progenitor (NMp) population. An autoregulatory loop...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev194415.
Published: 23 March 2021
... challenging. Although the induction of cells resembling neuromesodermal progenitors (NMPs), the bona fide precursors of the spinal cord, offers a promising solution, the progressive specification of posterior MNs from these cells is not well defined. Here, we determine the signals guiding the transition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev180612.
Published: 16 February 2021
... of various cell types from a pool of posteriorly-located axial progenitors. Here, we review the key features of this process and the biology of axial progenitors, including neuromesodermal progenitors, the common precursors of the spinal cord and trunk musculature. We discuss recent developments...
Journal Articles
Journal: Development
Development (2020) 147 (22): dev185298.
Published: 27 November 2020
...Zhi Ye; David Kimelman ABSTRACT The early vertebrate embryo extends from anterior to posterior due to the addition of neural and mesodermal cells from a neuromesodermal progenitor (NMp) population located at the most posterior end of the embryo. In order to produce mesoderm throughout this time...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev177659.
Published: 15 July 2019
...Naoyuki Tahara; Hiroko Kawakami; Katherine Q. Chen; Aaron Anderson; Malina Yamashita Peterson; Wuming Gong; Pruthvi Shah; Shinichi Hayashi; Ryuichi Nishinakamura; Yasushi Nakagawa; Daniel J. Garry; Yasuhiko Kawakami ABSTRACT Bi-potential neuromesodermal progenitors (NMPs) produce both neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev180190.
Published: 24 June 2019
..., 2000 ; Weinstein et al., 1994 ), suggesting a relationship between the node and the establishment and maintenance of the NMPs. However, little is known about these interactions. Neuromesodermal progenitors Single cells Transcription Summary: Single cell analysis of mouse PSC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev168187.
Published: 20 May 2019
.../user-licence-1-1/ Summary: A protocol that efficiently produces neuromesodermal progenitors from a multipotent population with progenitors for a variety of mesodermal derivatives. Embryonic stem cells Neuromesodermal progenitors Axial extension Mammalian development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev164319.
Published: 2 October 2018
... molecular markers to identify them. Here, we elucidate the expression pattern of the transcription factor Nkx1-2 in the mouse embryo and show that it identifies axial progenitors throughout body axis elongation, including neuromesodermal progenitors and early neural and mesodermal progenitors. We create...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev161091.
Published: 30 July 2018
... the expression, regulation and function of the Myc family during mouse embryonic axis elongation and segmentation. Expression of both cMyc ( Myc – Mouse Genome Informatics) and MycN in the domains in which neuromesodermal progenitors (NMPs) and underlying caudal pre-somitic mesoderm (cPSM) cells reside...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 244–254.
Published: 15 January 2016
...), with changes quantitated (C; raw data and statistics are provided in Table 1). Cell fate changes are statistically significant (see Table 1). Midline progenitor cells Tailbud Canonical Wnt Notch Posterior growth Notochord Floor plate Hypochord Mesogenin 1 MPC PWPC Neuromesodermal progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2864–2875.
Published: 1 September 2015
...Domingos Henrique; Elsa Abranches; Laure Verrier; Kate G. Storey Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of patterning of the anterior neural plate. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1209–1221.
Published: 15 March 2014
...) precursor, whereas later-ingressing somitic mesoderm is generated by a neuromesodermal (NM) progenitor, which also gives rise to the neurectoderm of the spinal cord ( Tzouanacou et al., 2009 ). Epiblast stem cells Gastrulation Heterogeneity Neuromesodermal progenitors Primitive Streak...
Includes: Supplementary data