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Keywords: Neural tube defect
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Neural development
Journal: Development
Development (2019) 146 (10): dev173765.
Published: 28 May 2019
... double knockout (dKO) mice display neural tube defects (NTDs) coupled with reduced proliferation and precocious differentiation of NPCs. Using ribosomal protein 24 hypomorphic mice ( Rpl24 Bst/+ ) as a genetic tool to dampen global protein synthesis, we found that Lin28a −/− ;Rpl24 Bst/+ compound mutants...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev169797.
Published: 13 December 2018
...Huili Li; Jing Zhang; Lee Niswander ABSTRACT Micronutrition is essential for neural tube closure, and zinc deficiency is associated with human neural tube defects. Here, we modeled zinc deficiency in mouse embryos, and used live imaging and molecular studies to determine how zinc deficiency affects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3079–3088.
Published: 15 September 2010
...Jinzhe Mao; David M. McKean; Sunita Warrier; Joshua G. Corbin; Lee Niswander; Irene E. Zohn Neural tube defects (NTDs) are some of the most common birth defects observed in humans. The incidence of NTDs can be reduced by peri-conceptional folic acid supplementation alone and reduced even further...
Journal Articles
Journal: Development
Development (2007) 134 (7): 1431–1441.
Published: 1 April 2007
... proteins govern epithelial cell behaviors by coordinating the assembly of both microtubule and actin cytoskeletons. * Author for correspondence (e-mail: wallingford@mail.utexas.edu ) 19 1 2007 © 2007. 2007 Shroom gamma-tubulin microtubule neural tube defect morphogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (24): 5815–5825.
Published: 15 December 2002
... for the looptail mouse, which lacks PCP signaling ( Kibar et al.,2001 ; Smith and Stein,1962 ; Wilson and Wyatt,1992 ). It will now be very interesting to assess directly the convergent extension of the neural plate at early stages in the looptail and Dishevelled mutant mice. Neural tube defects...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (11): 2347–2355.
Published: 1 June 2000
... that the orpk mutation is a hypomorphic allele of the Tg737 gene. Unlike the orpk allele, where all homozygotes survive to birth, embryos homozygous for the Tg737 Δ 2-3 α Gal mutation arrest in development at mid-gestation and exhibit neural tube defects, enlargement of the pericardial sac and, most notably...
Journal Articles
Journal: Development
Development (1998) 125 (2): 327–337.
Published: 15 January 1998
.... ( 1995 ). Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix . J. Biol. Chem . 270 , 22259 – 22262 . 10.1074/jbc.270.38.22259 Homologous recombination Gene targeting Neural tube defect Hypocardiogenesis Cytoskeletal...
Journal Articles
Journal Articles
Journal: Development
Development (1995) 121 (10): 3291–3301.
Published: 1 October 1995
... somite defect neural tube defect in situ hybridization homologous recombination mouse RBP-Jк is a unique transcription factor that does not contain any of the known DNA-binding protein motifs such as zinc finger, helix turn helix, helix loop helix and leucine zipper ( Matsunami et al., 1989...