... double knockout (dKO) mice display neural tube defects (NTDs) coupled with reduced proliferation and precocious differentiation of NPCs. Using ribosomal protein 24 hypomorphic mice ( Rpl24 Bst/+ ) as a genetic tool to dampen global protein synthesis, we found that Lin28a −/− ;Rpl24 Bst/+ compound mutants...

...Huili Li; Jing Zhang; Lee Niswander ABSTRACT Micronutrition is essential for neural tube closure, and zinc deficiency is associated with human neural tube defects. Here, we modeled zinc deficiency in mouse embryos, and used live imaging and molecular studies to determine how zinc deficiency affects...

...Jinzhe Mao; David M. McKean; Sunita Warrier; Joshua G. Corbin; Lee Niswander; Irene E. Zohn Neural tube defects (NTDs) are some of the most common birth defects observed in humans. The incidence of NTDs can be reduced by peri-conceptional folic acid supplementation alone and reduced even further...

... proteins govern epithelial cell behaviors by coordinating the assembly of both microtubule and actin cytoskeletons. * Author for correspondence (e-mail: wallingford@mail.utexas.edu ) 19 1 2007 © 2007. 2007 Shroom gamma-tubulin microtubule neural tube defect morphogenesis...

... for the looptail mouse, which lacks PCP signaling ( Kibar et al.,2001 ; Smith and Stein,1962 ; Wilson and Wyatt,1992 ). It will now be very interesting to assess directly the convergent extension of the neural plate at early stages in the looptail and Dishevelled mutant mice. Neural tube defects...

... of Cell Biology, NYU School of Medicine, New York, NY 10016, USA ‡ Author for correspondence (e-mail: w.richardson@ucl.ac.uk ) 09 10 2000 18 08 2000 © 2000 by Company of Biologists 2000 PDGF receptor-alpha YAC transgenesis Craniofacial development Neural tube defect...

... that the orpk mutation is a hypomorphic allele of the Tg737 gene. Unlike the orpk allele, where all homozygotes survive to birth, embryos homozygous for the Tg737 Δ 2-3 α Gal mutation arrest in development at mid-gestation and exhibit neural tube defects, enlargement of the pericardial sac and, most notably...

... Gene targeting Neural tube defect Hypocardiogenesis Cytoskeletal protein Attachment assay Focal adhesion plaque Cell migration Embryo fibroblast Focal adhesion kinase Paxillin pCAS 130 c-src Vinculin is a cytoskeletal protein of 117 kDa and is a major constituent of cell junctions...

... of development revealed developmental perturbations consisting of cranial neural tube defects (NTD) and heart malformations. Interestingly, breeding of the CMV43 transgene into the Cx43 knockout mice extended postnatal viability of mice homozygote for the Cx43 knockout allele, indicating that the CMV43 trangsene...

... somite defect neural tube defect in situ hybridization homologous recombination mouse RBP-Jк is a unique transcription factor that does not contain any of the known DNA-binding protein motifs such as zinc finger, helix turn helix, helix loop helix and leucine zipper ( Matsunami et al., 1989...