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Keywords: Neural tube
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Journal Articles
Journal: Development
Development (2023) 150 (19): dev202139.
Published: 10 October 2023
...Eirini Maniou; Faduma Farah; Abigail R. Marshall; Zoe Crane-Smith; Andrea Krstevski; Athanasia Stathopoulou; Nicholas D. E. Greene; Andrew J. Copp; Gabriel L. Galea ABSTRACT Closed spinal dysraphisms are poorly understood malformations classified as neural tube (NT) defects. Several, including...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201052.
Published: 18 October 2022
...JiSoo Park; Hao-An Hsiung; Irina Khven; Gioele La Manno; Matthias P. Lutolf ABSTRACT The embryonic neural tube is the origin of the entire adult nervous system, and disturbances in its development cause life-threatening birth defects. However, the study of mammalian neural tube development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (11): dev199660.
Published: 10 June 2022
...× Minimum Essential Medium (MEM; Gibco), 1× GlutaMax (Gibco) and neutralizing bicarbonate (Gibco)]. Four neural tube-containing collagen drops (5 µl) were distributed on a 35 mm glass-bottom culture dish (ibidi) (procedure modified from Das et al., 2012 ). Collagen polymerization was performed at 38°C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev192914.
Published: 15 December 2021
... possibilities to understand how boundary conditions that impose geometrical, mechanical and biochemical constraints pattern and shape the mammalian embryo. Morphogenesis Mechanobiology Self-organisation Embryogenesis Organoids Somitogenesis Neural tube Stem cells Gastruloids Stembryogenesis...
Journal Articles
Journal: Development
Development (2021) 148 (4): dev197566.
Published: 25 February 2021
... the sharp boundaries that delineate these gene expression patterns arise, despite the stochasticity associated with gene regulation, is poorly understood. We show, in the vertebrate neural tube, using perturbations of coding and regulatory regions, that the structure of the regulatory network contributes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev191494.
Published: 23 December 2020
...Andrew C. Symonds; Clare E. Buckley; Charlotte A. Williams; Jonathan D. W. Clarke ABSTRACT Using the zebrafish neural tube as a model, we uncover the in vivo mechanisms allowing the generation of two opposing apical epithelial surfaces within the centre of an initially unpolarised, solid organ. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183996.
Published: 26 May 2020
.... By investigating loss and gain of Shh function, and floor-plate deletions, we report that sclerotomal Shh is also necessary for neural tube development. Reducing the amount of Shh in the sclerotome using a membrane-tethered hedgehog-interacting protein or Patched1, but not dominant active Patched, decreased...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (23): dev176297.
Published: 4 December 2019
...Pilar Guerrero; Ruben Perez-Carrasco; Marcin Zagorski; David Page; Anna Kicheva; James Briscoe; Karen M. Page ABSTRACT Cell division, movement and differentiation contribute to pattern formation in developing tissues. This is the case in the vertebrate neural tube, in which neurons differentiate...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (22): dev182154.
Published: 25 November 2019
... Neural tube Neurogenesis Neuronal diversity Patterning The spinal cord is crucial for how we perceive and interact with our environment. Perception of sensory information from our skin, muscles and internal organs depends on the activities of several classes of neurons, the cell bodies...
Journal Articles
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (12): dev173807.
Published: 27 March 2019
...Julien Delile; Teresa Rayon; Manuela Melchionda; Amelia Edwards; James Briscoe; Andreas Sagner; Allon Klein; Barbara Treutlein ABSTRACT The coordinated spatial and temporal regulation of gene expression in the vertebrate neural tube determines the identity of neural progenitors and the function...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (4): 552–566.
Published: 15 February 2017
...Evanthia Nikolopoulou; Gabriel L. Galea; Ana Rolo; Nicholas D. E. Greene; Andrew J. Copp Neural tube closure has been studied for many decades, across a range of vertebrates, as a paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the severe congenital...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (12): 2183–2193.
Published: 15 June 2016
... µg/ml netrin 1 (R&D Systems), 0.5 mM L-glutamine (Gibco), 50 U/ml penicillin (Gibco) and 50 µg/ml streptomycin (Gibco). Wild-type and mutant mouse embryos (E13.5) were collected in cold PBS and dissected in cold Hank's Balanced Salt Solution (HBSS), 6.5% glucose (Gibco). Neural tubes were...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1305–1314.
Published: 1 April 2015
...Joaquim Grego-Bessa; Jeffrey Hildebrand; Kathryn V. Anderson The genetic control of mammalian epithelial polarity and dynamics can be studied in vivo at cellular resolution during morphogenesis of the mouse neural tube. The mouse neural plate is a simple epithelium that is transformed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (16): 3153–3158.
Published: 15 August 2014
... migration has not been studied in mammalian PCP mutants. Vangl2 Lp/Lp mouse embryos lack PCP signalling and undergo almost complete failure of neural tube closure. Here we show, however, that NC specification, migration and derivative formation occur normally in Vangl2 Lp/Lp embryos. The gene family member...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (7): 1467–1474.
Published: 1 April 2013
... differential gene expression. However, this view has been challenged, raising the possibility that distinct mechanisms are used to interpret different morphogens. Here, we investigate graded BMP signalling in the vertebrate neural tube. We show that defined exposure times to Bmp4 generate distinct levels...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 820–830.
Published: 15 February 2013
...Mary C. McKinney; Kazumi Fukatsu; Jason Morrison; Rebecca McLennan; Marianne E. Bronner; Paul M. Kulesa Neural crest (NC) cells emerge from the dorsal trunk neural tube (NT) and migrate ventrally to colonize neuronal derivatives, as well as dorsolaterally to form melanocytes. Here, we test whether...
Includes: Multimedia, Supplementary data