...Sophie E. Keegan; Julie Haskins; Andrew J. Simmonds; Sarah C. Hughes ABSTRACT Coordinated spatio-temporal regulation of the determination and differentiation of neural stem cells is essential for brain development. Failure to integrate multiple factors leads to defective brain structures or tumour...

...Stavroula Petridi; Dnyanesh Dubal; Richa Rikhy; Jelle van den Ameele ABSTRACT Neural stem cells (NSCs) in the developing and adult brain undergo many different transitions, tightly regulated by extrinsic and intrinsic factors. While the role of signalling pathways and transcription factors is well...

...Ángela del Águila; Mike Adam; Kristy Ullom; Nicholas Shaw; Shenyue Qin; Jacqueline Ehrman; Diana Nardini; Joseph Salomone; Brian Gebelein; Q. Richard Lu; Steven S. Potter; Ronald Waclaw; Kenneth Campbell; Masato Nakafuku ABSTRACT Distinct neural stem cells (NSCs) reside in different regions...

... of Biologists Ltd 2022 Summary: Notch signaling promotes neuroblast quiescence in Drosophila . Notch activity becomes attenuated in quiescent neuroblasts and low to no active Notch is required for neuroblast reactivation in response to dietary nutrients. Notch signaling Neural stem cell...

... and flexibility of cell polarity are implicated in the evolutionary expansion of the developing neocortex by promoting the amplification of neural progenitors and tangential migration of neurons. Brain development Brain evolution Cell polarity Neural stem cell Neuronal polarity Sigrid...

...Toshiyuki Ohtsuka; Ryoichiro Kageyama ABSTRACT Neural stem cells (NSCs) gradually alter their characteristics during mammalian neocortical development, resulting in the production of various neurons and glial cells, and remain in the postnatal brain as a source of adult neurogenesis. Notch-Hes...

... in prolonged mitosis due to extension of early mitotic stages. This disruption is correlated with depletion of the populations of upper layer neurons in the cortex. In contrast, early cortical neural stem cells proliferate and expand normally in the absence of Sp2. These results indicate a stage-specific...

.... In the telencephalon, the cell bodies of radial glia (RG) neural stem cells are localized in the ventricular zone (VZ), but they span the entire telencephalon with their processes ( Grandel et al., 2006 ; Adolf et al., 2006 ; Ganz et al., 2010 ). In the dorsal telencephalon (pallium), RG divide constitutively...

... knockout mice during development and after induced spinal cord injury in adults. Therefore, morphological changes in Wnt-producing cells appear to generate new Wnt signal targets. Wnt Morphogen Spinal cord Roof plate Neural stem cell Regeneration Mouse During embryogenesis and homeostasis...

...Anna E. Hakes; Leo Otsuki; Andrea H. Brand ABSTRACT Neural stem cells must balance symmetric and asymmetric cell divisions to generate a functioning brain of the correct size. In both the developing Drosophila visual system and mammalian cerebral cortex, symmetrically dividing neuroepithelial cells...

...Emmanuel Than-Trong; Sara Ortica-Gatti; Sébastien Mella; Chirag Nepal; Alessandro Alunni; Laure Bally-Cuif ABSTRACT Neural stem cells (NSCs) in the adult vertebrate brain are found in a quiescent state and can preserve long-lasting progenitor potential (stemness). Whether and how these two...

... is incomplete. In mice, under basal conditions, adult hippocampal neural stem cells (AH-NSCs) generate neurons and astrocytes, but not oligodendrocytes. The factors limiting oligodendrocyte production, however, remain unclear. Here, we reveal that the transcription factor NFIX plays a key role in this process...

...Caroline Dillard; Karine Narbonne-Reveau; Sophie Foppolo; Elodie Lanet; Cédric Maurange ABSTRACT Whether common principles regulate the self-renewing potential of neural stem cells (NSCs) throughout the developing central nervous system is still unclear. In the Drosophila ventral nerve cord...

... 2017. Published by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: Endothelium-derived soluble amyloid precursor protein negatively regulates the growth of neural stem cells to control neural stem cell number in the subventricular zone of the adult...

... are the predominant stem cell type to support cerebellar regeneration after injury in Zebrafish, as opposed to radial glia-like cells, which play a relatively minor role. Zebrafish Cerebellum Neural stem cell Neurogenesis Radial glia Regeneration Neural stem and progenitor cell populations...

...Raul Bardini Bressan; Pooran Singh Dewari; Maria Kalantzaki; Ester Gangoso; Mantas Matjusaitis; Claudia Garcia-Diaz; Carla Blin; Vivien Grant; Harry Bulstrode; Sabine Gogolok; William C. Skarnes; Steven M. Pollard Mammalian neural stem cell (NSC) lines provide a tractable model for discovery across...

... compartment or only from the compartment of origin, i.e. spiral ganglion, vestibular epithelium or OC. Potency of neural stem cells has been difficult to determine without adequate markers to use for tracing the lineage of progenitor cells and for the differentiated progeny, and, as a result, similar...

... that was presented at the Fusion meeting on Adult Neurogenesis, which was held in March 2016 in Cancun, Mexico. Adult neurogenesis Hippocampus Human pluripotent stem cell Neural stem cell Neurological disease Subventricular zone The human brain is complex, with millions of neuronal subtypes...

... level and the origin for the numerous distinct neurons present in a complex brain. Neural stem cell RNA-seq Transcription factor Type II neuroblast Antennal lobe Mushroom body The complex brain consists of numerous distinct types of neuron. Generating such cellular diversity involves...

... in vitro . Myelin Remyelination Astrocyte Stem cell Neural stem cell Glial progenitor cell Multiple sclerosis Leukodystrophy White matter Oligodendrocytes are the myelinating cells of the central nervous system (CNS), and the last major neural phenotype to form during development...