... neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from the dorsal telencephalon, whereas inhibitory interneurons are generated in its ventral portion. The transcriptional regulator PRDM16 is expressed by radial glia, neural progenitors present in both...

... the fast evolution of the human cortex. Cajal-Retzius cells Cortical folding Neural progenitors Neural stem cells Reelin The human cerebral cortex is probably the most-complex structure elaborated during biological evolution ( Rakic, 2009 ). Essential to our unique cognitive abilities...

... signaling response, likely by modulating primary cilia. MicroRNA Polarity Hedgehog Neural progenitors Zebrafish Spatial and temporal information are integrated in developing nervous systems to produce a large array of distinct types of neurons and glia. In very broad terms, spatial cues...

... Neural specification SoxC SoxB2 Brn1/2/4 ELAV FGF Neural progenitors Neural precursors Deuterostomes Evolution Strongylocentrotus purpuratus Diverse developmental mechanisms mediate the specification and differentiation of metazoan nervous systems. There are similarities suggesting...

...Robert N. Duncan; Yuanyuan Xie; Adam D. McPherson; Andrew V. Taibi; Joshua L. Bonkowsky; Adam D. Douglass; Richard I. Dorsky The vertebrate hypothalamus contains persistent radial glia that have been proposed to function as neural progenitors. In zebrafish, a high level of postembryonic...

... system allows for such targeted mutagenesis, and we therefore tested it in combination with a piggyBac transposase lineage labeling system to track the development of neocortical neural progenitors with targeted mutations in genes linked to neurodevelopmental disruptions and tumor formation. We show...

... reflects an increase in the number of neocortical neurons, which is determined during development and primarily reflects the number of neurogenic divisions of distinct classes of neural progenitor cells. Consequently, the evolutionary expansion of the neocortex and the concomitant increase in the numbers...

.... * Author for correspondence ( troy_ghashghaei@ncsu.edu ) Competing interests statement The authors declare no competing financial interests. 15 11 2012 © 2013. Published by The Company of Biologists Ltd 2013 Neurogenesis Neural stem cells Neural progenitors Sp2 Cell cycle M...

... is specifically expressed in radial glia and SVZ neural progenitors during human brain development. Expression of GFAPδ in radial glia starts at around 13 weeks of pregnancy and disappears before birth. GFAPδ is continuously expressed in the SVZ progenitors at later gestational ages and in the postnatal brain. Co...

... activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors. These findings suggest that Lfng acts in a feedback loop downstream of proneural genes, which, by promoting Notch activation, maintains the sensitivity of progenitors to lateral inhibition...

... how heterogeneous the neural progenitor cells are, owing to dynamic changes in their nuclear position and gene expression. To address this issue, we systematically analyzed the cDNA profiles of a large number of single progenitor cells at the mid-embryonic stage in mouse. By cluster analysis...

...Levan Mchedlishvili; Hans H. Epperlein; Anja Telzerow; Elly M. Tanaka Complete regeneration of the spinal cord occurs after tail regeneration in urodele amphibians such as the axolotl. Little is known about how neural progenitor cells are recruited from the mature tail, how they populate...

... prolongs neural proliferation by maintaining a mitotically active neuroblast. In the abdomen, Grh terminates neural proliferation by regulating the competence of neuroblasts to undergo apoptosis in response to Abdominal-A expression. This study shows how a factor specific to late-stage neural progenitors...

...Ari A. Gershon; Jeremy Rudnick; Lobina Kalam; Kathryn Zimmerman ABSTRACT The development of the vertebrate nervous system depends upon striking a balance between differentiating neurons and neural progenitors in the early embryo. Our findings suggest that the homeodomain-containing gene Xdbx...

... of Biologists 1997 neurogenesis neural progenitors olfactory epithelium olfactory placodes olfactory receptor neurons bHLH proteins Mash1 NeuroD achaete-scute homolog atonal homolog mouse The process of neurogenesis in the nervous system of vertebrates produces a large variety...

... expression of AS-C, in specific locations within the developing cuticle, are not understood. 20 December 1993 © 1994 by Company of Biologists 1994 retina neural progenitors achaete - scute homolog During the development of the vertebrate central nervous system, a large...