.... ( 2003 ). T-antigen of human polyomavirus JC cooperates with IGF-IRS singaling system in cerebellar tumors of the childhood-medulloblastomas. Anticancer Res. 23 , 2035 -2041. Knoepfler, P. and Kenney, A. ( 2006 ). Neural precursors cycling at sonic speed: N-Myc pedals, GSK-3 breaks. Cell Cycle...

... and subsequently specify oligodendrocyte development. Our studies show that spatial and temporal differences in Hh signaling within a common population of neural precursors can contribute to cell fate diversification. † Author for correspondence (e mail: b.appel@vanderbilt.edu ) * These authors contributed...

... process of neural precursor cell (NPC) selection by basic helix-loop-helix (bHLH) proneural transcription factors in the peripheral nervous system (PNS) by atonal related proteins (ARPs) presents an excellent model in which to address this issue. Proneural ARPs belong to two highly related groups...

... © 2004. 2004 Cerebellum Sonic hedgehog Proliferation GSK3 Medulloblastoma Myc Neural precursor Mouse Nmyc1 (N-myc) Developmental programs that coordinate neuronal precursor proliferation and cell cycle exit are poorly understood. Signaling by the secreted factor Sonic hedgehog...

... Cerebellum Sonic hedgehog Proliferation Cyclopamine Medulloblastoma Nmyc Neural precursor TRRAP Mouse Signaling by the hedgehog family of secreted glycoproteins has been highly conserved through evolution ( Ingham and McMahon, 2001 ). Hedgehog activity is required for fundamental processes...

...Thomas S. Jacques; João B. Relvas; Stephen Nishimura; Robert Pytela; Gwynneth M. Edwards; Charles H. Streuli; Charles ffrench-Constant* ABSTRACT Proliferation and tangential migration of neural precursor cells are essential determinants of CNS development. We have established cell culture models...

...) that give rise to neural precursors, asense is one of a number of genes that are specifically expressed in the neural precursors themselves (the neural precursor genes). We have identified a mutant asense phenotype that may reflect this later expression pattern. As a step in understanding the determination...