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Keywords: Neural induction
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Journal Articles
Journal: Development
Development (2018) 145 (5): dev159525.
Published: 9 March 2018
... the spatiotemporal dispersion of equivalent elements in mouse and the key influence of responsiveness to organizer signals. Axial organization Spemann Body plan Neural induction Organizer Vertebrate embryo In the context of an embryo, an ‘organizer’ refers to a group of cells that harbour...
Journal Articles
Journal: Development
Development (2017) 144 (1): 33–37.
Published: 1 January 2017
... , L. ( 2005 ). Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition . Development   132 , 299 - 310 . 10.1242/dev.01582 Hoffman , T. L. , Javier , A. L. , Campeau , S. A. , Knight , R. D. and Schilling , T. F. ( 2007 ). Tfap2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2864–2875.
Published: 1 September 2015
... system: as well as the neuroectoderm lineage, neuromesodermal progenitors contribute to the spinal cord. Neuromesodermal progenitors Wnt FGF Bipotent cells Neural induction Spinal cord Stem cells The vertebrate central nervous system (CNS) is first manifest as an ovoid region...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2611–2618.
Published: 15 June 2013
... target of miR-96 family members via gain- and loss-of-function analyses. Given the essential roles of ZEBs and PAX6 in neural induction, we propose a model by which miR-200 and miR-96 families coordinate to regulate neural induction. Under a chemically defined culture system, hESCs differentiate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 147–155.
Published: 1 January 2013
... ) that is transiently expressed in the developing neural plate in a temporal window corresponding to the period of a-lineage neural induction. Using a genetically encoded calcium indicator we observed multiple calcium transients throughout the developing neural plate in wild-type embryos, but not in mutant embryos...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 1034–1044.
Published: 1 March 2012
... ) Competing interests statement The authors declare no competing financial interests. 3 1 2012 © 2012. Neural induction Neural plate Neural border Anterior neural ridge Secondary prosencephalon Forebrain Telencephalon Fate map Neural patterning Cell...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 575–584.
Published: 15 February 2009
...Sei Kuriyama; Roberto Mayor Syndecan-4 (Syn4) is a heparan sulphate proteoglycan that is able to bind to some growth factors, including FGF, and can control cell migration. Here we describe a new role for Syn4 in neural induction in Xenopus . Syn4 is expressed in dorsal ectoderm and becomes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3861–3872.
Published: 1 November 2007
...Chenbei Chang; Richard M. Harland Vertebrate neural induction requires inhibition of bone morphogenetic protein (BMP) signaling in the ectoderm. However, whether inhibition of BMP signaling is sufficient to induce neural tissues in vivo remains controversial. Here we have addressed why inhibition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3359–3369.
Published: 15 September 2007
... required for neural induction in the mouse. We have analysed the role of BMP signalling in this process. We demonstrate that prior to gastrulation, Bmp2/4 signalling via Bmpr1a maintains epiblast pluripotency and prevents precocious neural differentiation of this tissue, at least in part by maintaining...
Journal Articles
Journal: Development
Development (2007) 134 (16): 2889–2894.
Published: 15 August 2007
...., 2003 ). We cross-reference our in vitro findings in vivo using the chick embryo, a well-studied model organism for the process of neural induction in higher vertebrates ( Stern, 2005a ; Streit and Stern, 1999 ). Here,early (preneural) genes that identify potential neural tissue include a different...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (16): 3265–3276.
Published: 15 August 2006
... of chordin . * Author for correspondence (e-mail: eweinber@sas.upenn.edu ) 9 6 2006 © 2006. 2006 β-Catenin FGF signaling Dorsal axis formation Neural induction Dorsoventral patterning Anteroposterior patterning Organizer Nodal Chordin Zebrafish FGF signaling...
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Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (15): 3581–3592.
Published: 1 August 2004
...., Yamashita, S., Shimizu,T., Solnica-Krezel, L., Hibi, M. and Hirano, T. ( 2000 ). Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Dev. Biol. 217 , 138 -152. Hongo, I., Kengaku, M. and Okamoto, H. ( 1999 ). FGF signaling and the anterior neural induction...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2071–2081.
Published: 15 May 2003
... suggests that EGF-CFC genes can also activate certain cellular responses independently of nodal signaling. Here, we show that FRL-1 , a Xenopus EGF-CFC gene, suppresses BMP signaling to regulate an early step in neural induction. Overexpression of FRL-1 in animal caps induced the early neural markers zic3...
Journal Articles
Journal: Development
Development (2003) 130 (2): 331–342.
Published: 15 January 2003
... expansion, consistent with conclusions drawn from overexpression studies ( Feledy et al., 1999 ; Luo et al., 2001b ). To ensure that the effects on the neural plate were not limited to Xsox2 or to early stages of neural induction, we examined the effects of the Dlx constructs on NCAM expression. NCAM...
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (23): 5421–5436.
Published: 1 December 2002
...' fragment). Their different inducing abilities were tested by conjugating either `green' or `brown' fragments with stage 9 animal caps,followed by in situ hybridization analysis of the conjugates at the corresponding of stage 22/23. A weak anterior neural induction was detected in the conjugates...