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Keywords: Neural development
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Journal Articles
Journal: Development
Development (2022) 149 (20): dev200506.
Published: 18 October 2022
... by The Company of Biologists Ltd 2022 Summary: This Spotlight discusses how findings in intestinal and cancer organoids could be applied to neural organoid models to probe metabolic changes during human neurodevelopment. Metabolism Neural development Organoids In vitro models National...
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201052.
Published: 18 October 2022
... to the accessibility of this model, phagocytosis of migrating neural crest cells could be observed in real time for the first time in a mammalian model. We thus introduce a tractable in vitro model to study some of the key morphogenetic and cell type derivation events during early neural development. * Author...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (17): dev200677.
Published: 7 September 2022
... the temporal cascade and neural stem cell competence in the embryonic central nervous system. Temporal patterning Neural development Neural stem cells Chronophage CTIP1/2 Bcl11a Bcl11b European Molecular Biology Organization http://dx.doi.org/10.13039/100004410 Wellcome Trust...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2020) 147 (12): dev184093.
Published: 22 June 2020
... as a homodimer to dominantly impose neural identity on pluripotent cells. E2A BHLH Neural development Pluripotent Following the establishment of the primary germ layers during gastrulation, the embryonic neural plate is specified from the anterior ectoderm at approximately embryonic day (E)7.5...
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Neural development
Journal: Development
Development (2020) 147 (4): dev182204.
Published: 26 February 2020
.... To examine the effect of altered oscillatory dynamics of Hes1, we generated two types of Hes1 knock-in mice, a shortened (type-1) and an elongated (type-2) Hes1 gene, and examined their phenotypes focusing on neural development. Although both mutations affected Hes1 oscillations, the type-1 mutation dampened...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev183269.
Published: 8 November 2019
.... Cadherin FGF Neural development Pluripotent Wnt Mouse There is an increasing appreciation that changes in adhesion and morphology help to regulate cell fate changes ( Gilmour et al., 2017 ). The homotypic adhesion molecule E-cadherin (also known as cadherin 1) is expressed on the surface...
Includes: Supplementary data
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In collection:
Neural development
Journal: Development
Development (2019) 146 (12): dev173807.
Published: 27 March 2019
... and their associated gene expression profiles, identifying co-regulated genes that mediate a temporal programme of neuronal subtype specification. Spinal cord Neural development Neural tube ScRNA-seq Single cell transcriptomics Neuronal circuits in the spinal cord receive and process incoming sensory...
Includes: Supplementary data
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In collection:
Neural development
Journal: Development
Development (2019) 146 (2): dev169763.
Published: 29 January 2019
... work is properly attributed. Summary: RNA interference identifies SoxN and Sox102F as key regulators of the morphological properties of a neuronal type of the fruit fly visual system that computes the direction of motion. Neural development Layer specificity Optic lobe Drosophila...
Includes: Supplementary data
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In collection:
Neural development
Journal: Development
Development (2018) 145 (22): dev172049.
Published: 19 November 2018
... of Biologists on ‘Thinking beyond the dish: taking in vitro neural differentiation to the next level’, highlighting the limitations and potential applications of organoid-based technologies. Neural development Organoids In vitro Neural differentiation Developmental biology aims...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (10): dev151415.
Published: 14 May 2018
..., highlighting recent studies that question the textbook model of axon guidance. Axon guidance Guidance cues Neural development Local translation MicroRNA Vesicular transport Neural circuits are the basis of neural function in health and disease, and the faulty assembly or disintegration...
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In collection:
Neural development
Journal: Development
Development (2018) 145 (9): dev159426.
Published: 2 May 2018
.... bHLH gene Neural development Neurogenesis Neuronal diversity Proneural gene The function of the nervous system relies on a large number of neurons with diverse functions. Even the simple nervous system of the nematode C. elegans has more than 100 classes of neurons, and this number...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (3): dev157446.
Published: 2 February 2018
... with abnormal axon innervation and defective peristalsis of the midgut. Neural development Enteric nervous system Ret signaling GDNF signaling Axon branching Drosophila The RET (rearranged during transfection) receptor tyrosine kinase is the leading susceptibility locus for Hirschsprung's...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3744–3754.
Published: 15 October 2017
... throughout the pancreas. A screen of pancreatic extracellular signals identified factors that stimulated islet cell development. These included semaphorin 3a, a guidance cue in neural development without known functions in the pancreas. In the fetal pancreas, peripheral mesenchymal cells expressed Sema3a...
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In collection:
Neural development
Journal: Development
Development (2017) 144 (10): 1807–1819.
Published: 15 May 2017
... circuit Neural development E/I balance Neurons in the brain are organized into circuits, and the activity of these circuits is regulated by the integration of excitatory and inhibitory synaptic inputs. Thus, appropriate numbers and proper positioning of excitatory and inhibitory synaptic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (7): 1160–1169.
Published: 1 April 2016
... that terminates G2 phase arrest and promotes neural development might be extrinsic to the pI cell. An appealing candidate for an extrinsic signal would be the steroid hormone ecdysone, because pI cell division in the microchaetae lineage roughly coincides with a minor peak in ecdysone expression ( Truman et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3286–3293.
Published: 1 October 2015
... by The Company of Biologists Ltd 2015 Summary: Unbiased functional genomics approaches reveal that Nkx2.2, Nkx6.1 and Olig2 directly repress multiple alternative fates during mammalian neural progenitor fate specification. Transcriptional regulation Fate specification Neural development Mouse...
Includes: Supplementary data
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