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Keywords: Neural crest
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Journal Articles
Journal: Development
Development (2022) 149 (7): dev197947.
Published: 31 March 2022
... understanding of how physical forces influence developing sensory organs, both in the embryo and in organoid cultures. Mechanobiology Sensory development Neural crest Placodes Stem cells Organoids National Institute on Deafness and Other Communication Disorders http://dx.doi.org/10.13039...
Journal Articles
Journal: Development
Development (2022) 149 (4): dev200082.
Published: 24 February 2022
...Lomeli C. Shull; Ezra S. Lencer; Hyun Min Kim; Susumu Goyama; Mineo Kurokawa; James C. Costello; Kenneth Jones; Kristin B. Artinger ABSTRACT Cranial neural crest cell (NCC)-derived chondrocyte precursors undergo a dynamic differentiation and maturation process to establish a scaffold for subsequent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev200001.
Published: 2 December 2021
... ion channel Piezo1 on the migration of the neural crest, a multipotent embryonic cell population. We identify that Piezo1 is required for the migration of Xenopus cephalic neural crest. We show that loss of Piezo1 promotes focal adhesion turnover and cytoskeletal dynamics by controlling Rac1 activity...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (22): dev199468.
Published: 17 November 2021
...Jason A. Morrison; Rebecca McLennan; Jessica M. Teddy; Allison R. Scott; Jennifer C. Kasemeier-Kulesa; Madelaine M. Gogol; Paul M. Kulesa ABSTRACT The dynamics of multipotent neural crest cell differentiation and invasion as cells travel throughout the vertebrate embryo remain unclear. Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199684.
Published: 6 September 2021
.... 239 , 3446 - 3466 . 10.1002/dvdy.22484 Neilson , K. M. , Abbruzzesse , G. , Kenyon , K. , Bartolo , V. , Krohn , P. , Alfandari , D. and Moody , S. A. ( 2017 ). Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development . Dev. Biol...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199448.
Published: 13 July 2021
... that ablation of Srsf3 in the mouse neural crest lineage leads to facial clefting due to defective cranial neural crest cell proliferation and survival. Finally, we show that Srsf3 regulates the alternative RNA splicing of transcripts encoding protein kinases in the mouse facial process mesenchyme to regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev199441.
Published: 17 May 2021
... embryonic lethality. Here, we showed that kindlin2 is essential for neural crest (NC) formation in Xenopus embryos. Loss-of-function assays performed with kindlin2- specific morpholino antisense oligos (MOs) or with CRISPR/Cas9 techniques in Xenopus embryos severely inhibit the specification of the NC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev193565.
Published: 15 April 2021
... retroviruses allowed us to couple gene knockouts with long-term lineage analysis. We demonstrate the application of our newly engineered constructs and viruses by perturbing β-catenin in vitro and Sox10 , Pax6 and Pax7 in the neural crest, retina, and neural tube and segmental plate in vivo , respectively...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev196030.
Published: 15 February 2021
...Natalie J. Milmoe; Abigail S. Tucker ABSTRACT Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193888.
Published: 26 October 2020
...Manuel Rocha; Anastasia Beiriger; Elaine E. Kushkowski; Tetsuto Miyashita; Noor Singh; Vishruth Venkataraman; Victoria E. Prince ABSTRACT The neural crest is regionalized along the anteroposterior axis, as demonstrated by foundational lineage-tracing experiments that showed the restricted...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193193.
Published: 23 October 2020
...Weiyi Tang; Marianne E. Bronner ABSTRACT Since its discovery 150 years ago, the neural crest has intrigued investigators owing to its remarkable developmental potential and extensive migratory ability. Cell lineage analysis has been an essential tool for exploring neural crest cell fate...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (21): dev187997.
Published: 17 July 2020
... of KS2 patients, it is not clear whether differences exist in clinical manifestations relative to KS1. We mutated KMT2D in neural crest cells (NCCs) to study cellular and molecular functions in craniofacial development with respect to UTX. Similar to UTX, KMT2D NCC knockout mice demonstrate hypoplasia...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (13): dev186619.
Published: 13 July 2020
...Wael Noor El-Nachef; Marianne E. Bronner ABSTRACT The enteric nervous system (ENS) is essential for normal gastrointestinal function. Although the embryonic origin of enteric neurons from the neural crest is well established, conflicting evidence exists regarding postnatal enteric neurogenesis...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (21): dev187047.
Published: 13 July 2020
... mutants possess severe colobomas and our data demonstrate that Mitf activity is required within cranial neural crest cells (cNCCs) during CF closure. In the absence of Mitf function, cNCC migration and localization in the optic cup are perturbed. These data shed light on the cellular mechanisms underlying...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev183954.
Published: 12 April 2020
... and experimental demonstration of the physiological relevance of such activities are rare. Here, we have used chick neural crest (NC) cells, a highly migratory stem cell population likened to invasive cancer cells, as a model for physiological epithelial-mesenchymal transition (EMT). We demonstrate that MMP14...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181420.
Published: 21 February 2020
... in the developing optic cup require neural crest. Ultrastructural analysis reveals that basement membrane formation around the developing eye is also dependent on neural crest, but only specifically around the retinal pigment epithelium. Neural crest cells produce the extracellular matrix protein nidogen: impairing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (1): dev185231.
Published: 9 January 2020
...Rebecca McLennan; Mary C. McKinney; Jessica M. Teddy; Jason A. Morrison; Jennifer C. Kasemeier-Kulesa; Dennis A. Ridenour; Craig A. Manthe; Rasa Giniunaite; Martin Robinson; Ruth E. Baker; Philip K. Maini; Paul M. Kulesa ABSTRACT Neural crest migration requires cells to move through an environment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev180133.
Published: 16 December 2019
... types during embryogenesis. We show the RNA polymerase-associated factor 1 complex (Paf1C) is required to maintain multipotent progenitors of the neural crest (NC) lineage in zebrafish. Mutations affecting each Paf1C component result in near-identical NC phenotypes; alyron mutant embryos carrying a null...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev180075.
Published: 12 November 2019
... and disrupted intrinsic muscle patterning, with these defects reproduced following global Shh deletion from E10.5 in pCag - CreERTM; Shhflox/flox embryos. SHH responsiveness was diminished in local cranial neural crest cell (CNCC) populations in both mutants, with SHH targeting these cells through the primary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (18): dev177618.
Published: 23 September 2019
... endoderm. Pharyngeal endoderm Arch artery development Tbx1 Pax9 Neural crest 22q11 deletion syndrome Conotruncal heart malformations, which affect the outflow tract and aortic arch arteries, occur in 30% of all cases of congenital heart defects ( Thom et al., 2006 ). Approximately 20...
Includes: Supplementary data