... neogenin (NEO1) and its membrane-bound ligand RGMB control the balance of neurons and glial cells produced in the OE. In this layered epithelium, neogenin is expressed in progenitor cells, while RGMB is restricted to adjacent newly born ORNs. Ablation of Rgmb via gene-targeting increases the number...

...Chenxi Tian; Herong Shi; Shan Xiong; Fenghua Hu; Wen-Cheng Xiong; Jun Liu The deleted in colorectal cancer (DCC) homolog neogenin functions in both netrin- and repulsive guidance molecule (RGM)-mediated axon guidance and in bone morphogenetic protein (BMP) signaling. How neogenin functions...

... statement The authors declare no competing financial interests. © 2011. 2011 DCC Adhesion Axon Neogenin Netrin UNC5 Netrins are a family of extracellular, laminin-related (see Glossary, Box 1 ) proteins that function as chemotropic guidance cues for migrating cells and axons...

..., respectively, and may mediate interactions between cells within a given layer ( Daniel et al., 1995 ; Radice et al.,1997 ). Interactions between the cell layers, at least in the EB,are provided by the secreted cue netrin 1 ( Ntn1 ), which is expressed by LECs, and binds its receptor neogenin ( Neo1 ), present...