...Cristina Brischetto; Karsten Krieger; Christian Klotz; Inge Krahn; Séverine Kunz; Marina Kolesnichenko; Patrick Mucka; Julian Heuberger; Claus Scheidereit; Ruth Schmidt-Ullrich ABSTRACT Although the role of the transcription factor NF-κB in intestinal inflammation and tumor formation has been...

... to investigate nuclear factor kappa B (NF-κB) signaling, a critical regulator of inflammation, during the reprogramming of Müller glia into proliferating progenitors. We find that components of the NF-κB pathway are dynamically regulated by Müller glia after neuronal damage or treatment with growth factors...

... that Toll/TLRs carry out previously unanticipated functions in development, regulating cell fate, cell number, neural circuit connectivity and synaptogenesis. Furthermore, knowledge of their molecular mechanisms of action is expanding and has highlighted that Toll/TLRs function beyond the canonical NF-κB...

...Philip Tomann; Ralf Paus; Sarah E. Millar; Claus Scheidereit; Ruth Schmidt-Ullrich ABSTRACT In the epidermis of mice lacking transcription factor nuclear factor-kappa B (NF-κB) activity, primary hair follicle (HF) pre-placode formation is initiated without progression to proper placodes. NF-κB...

... growth and branching of the SMG via transcription factor NF-κB in the epithelium, and that the hedgehog pathway is an important mediator of Eda/NF-κB. We also sought to determine whether a similar reciprocal interplay between the Eda and Wnt/β-catenin pathways, which are known to operate in other skin...

... of a developmental switch in the intracellular signalling network required for an identical cellular response to the same extracellular signal in the same cell type. We show that although NF-κB signalling is required for BDNF-promoted neurite growth from both foetal and postnatal mouse sensory neurons...

...Robert DeLotto; Yvonne DeLotto; Ruth Steward; Jennifer Lippincott-Schwartz In Drosophila , the NF-κB/REL family transcription factor,Dorsal, redistributes from the cytoplasm to nuclei, forming a concentration gradient across the dorsoventral axis of the embryo. Using live imaging techniques...

... are likely to be mediated by transcription factor nuclear factor-κB (NF-κB), but the transcriptional targets of Edar have remained unknown. Using a quantitative approach, we show in cultured embryonic skin that Eda induced the expression of two Bmp inhibitors, Ccn2/Ctgf (CCN family protein 2/connective...

...Ruth Schmidt-Ullrich; Desmond J. Tobin; Diana Lenhard; Pascal Schneider; Ralf Paus; Claus Scheidereit A novel function of NF-κB in the development of most ectodermal appendages, including two types of murine pelage hair follicles, was detected in a mouse model with suppressed NF-κB activity( c...

...Humberto Gutierrez; Valerie A. Hale; Xavier Dolcet; Alun Davies The proper growth and elaboration of neural processes is essential for the establishment of a functional nervous system during development and is an integral feature of neural plasticity throughout life. Nuclear factor-kappa B(NF-κB...

... by Company of Biologists 1998 Dorsal NF-κB IL-1 Receptor Dorsoventral polarity plasma membrane Signal transduction Drosophila To determine whether the asymmetric distribution of Tube depends on Toll-mediated signaling, we examined Tube localization in genetic backgrounds that either...