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Keywords: Myotome
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Journal Articles
Journal: Development
Development (2020) 147 (10): dev183996.
Published: 26 May 2020
...Nitza Kahane; Chaya Kalcheim ABSTRACT Sonic hedgehog (Shh), produced in the notochord and floor plate, is necessary for both neural and mesodermal development. To reach the myotome, Shh has to traverse the sclerotome and a reduction of sclerotomal Shh affects myotome differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1159–1168.
Published: 15 March 2015
... correlates with a deficit in dermomyotome and myotome marker gene expression, suggesting that Ripply1 promotes myogenesis by terminating Tbx6-dependent inhibition of myogenic maturation. Together, our data suggest that Mesp-b is an intrinsic upstream regulator of skeletal muscle progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3605–3611.
Published: 15 September 2014
..., the addition of nuclei in limb muscles is three times more rapid than in trunk and is tightly associated with fiber growth. A complex interaction takes place in the trunk, where primary myotome cells from the medial somite border rarely fuse to one another, but readily do so with anterior and posterior border...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1740–1750.
Published: 15 April 2013
...Nitza Kahane; Vanessa Ribes; Anna Kicheva; James Briscoe; Chaya Kalcheim The development of a functional tissue requires coordination of the amplification of progenitors and their differentiation into specific cell types. The molecular basis for this coordination during myotome ontogeny is not well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (19): 4155–4166.
Published: 1 October 2011
... cells divide with a planar orientation. Here, we report that in the avian embryo, in addition to self-renewing, a subset of progenitors translocates into the myotome where they generate differentiated myocytes. By contrast, in the late epithelium, individual progenitors divide perpendicularly to produce...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2935–2945.
Published: 15 July 2011
...Osnat Halperin-Barlev; Chaya Kalcheim Pioneer myoblasts generate the first myotomal fibers and act as a scaffold to pattern further myotome development. From their origin in the medial epithelial somite, they dissociate and migrate towards the rostral edge of each somite, from which differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 755–765.
Published: 15 February 2011
...Ashish K. Maurya; Haihan Tan; Marcel Souren; Xingang Wang; Joachim Wittbrodt; Philip W. Ingham Different levels and timing of Hedgehog (Hh) signalling activity have been proposed to specify three distinct cell types in the zebrafish myotome. Two of these, the medial fast-twitch fibres (MFFs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (20): 3495–3504.
Published: 15 October 2009
... of basement membranes and are thought to be essential for initiation of basement membrane assembly. Here, we report that muscle progenitor cells populating the myotome migrate aberrantly in the ventral somite in the absence of sonic hedgehog (Shh) signalling, and we show that this defect is due to the failure...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (12): 2115–2126.
Published: 15 June 2008
... embryo. Genes Dev. 15 , 1563 -1576. Sacks, L. D., Cann, G. M., Nikovits, W., Jr, Conlon, S.,Espinoza, N. R. and Stockdale, F. E. ( 2003 ). Regulation of myosin expression during myotome formation. Development 130 , 3391 -3402. Schilling, T. F. and Kimmel, C. B. ( 1997 ). Musculoskeletal...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3251–3257.
Published: 15 September 2007
...: granatom@mail.med.upenn.edu ) 10 7 2007 © 2007. 2007 Zebrafish Growth cone Axon Guidance Myotome Plexin A3 Sidetracked Spinal motoneuron In recent years, many of the basic principles of axonal guidance have been defined at the molecular and cellular levels (reviewed...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (7): 1253–1257.
Published: 1 April 2007
... for growth have not been identified. We have used single cell lineage labeling in zebrafish to show that anterior border cells of epithelial somites are myogenic precursors responsible for zebrafish myotome growth. These cells move to the external surface of the embryonic myotome and express...
Journal Articles
Journal: Development
Development (2006) 133 (9): 1635–1644.
Published: 1 May 2006
...Fernanda Bajanca; Marta Luz; Karine Raymond; Gabriel G. Martins; Arnoud Sonnenberg; Shahragim Tajbakhsh; Margaret Buckingham; Sólveig Thorsteinsdóttir We addressed the potential role of cell-laminin interactions during epaxial myotome formation in the mouse embryo. Assembly of the myotomal...
Journal Articles
Journal: Development
Development (2005) 132 (20): 4461–4470.
Published: 15 October 2005
... cells. Thus, if Eph family members regulate neural crest migration patterning in zebrafish, the molecular mechanisms are likely to be distinct from those of avian and mammalian embryos, because in zebrafish neural crest migration occurs in the middle of the medial myotome surface, rather than through...
Journal Articles
Journal: Development
Development (2005) 132 (9): 2235–2249.
Published: 1 May 2005
... by apoptosis. At the interlimb level, epaxial Met expression is abolished, while it is preserved in Pax3 -deficient embryos. Within the myotome, absence of Six1 and Six4 impairs the expression of the myogenic regulatory factors myogenin and Myod1, and Mrf4 expression becomes undetectable. Myf5 expression...
Journal Articles
Journal: Development
Development (2005) 132 (4): 689–701.
Published: 15 February 2005
...Raz Ben-Yair; Chaya Kalcheim The dermomyotome develops into myotome and dermis. We previously showed that overall growth of the dermomyotome and myotome in the mediolateral direction occurs in a uniform pattern. While myofibers arise from all four dermomyotome lips, the dermis derives from both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (3): 515–528.
Published: 1 February 2005
... compartments, the myotome and sclerotome, in response to signals secreted from surrounding tissues. As the somite matures, the tendon lineage is established within the dorsolateral sclerotome, adjacent to and beneath the myotome. We examine interactions between the three lineages by observing tendon...
Journal Articles
Journal: Development
Development (2004) 131 (16): 3967–3980.
Published: 15 August 2004
... angioblasts to endothelial cells within and surrounding the brain. The early pattern of gene expression by transplant-derived cells was assessed using markers for dermamyotome ( paraxis ), lateral myotome( lbx1 ) and myogenic lineage ( myf5, myod ) commitment. In the head, paraxis is normally...
Journal Articles
Journal: Development
Development (2003) 130 (18): 4325–4336.
Published: 15 September 2003
...Raz Ben-Yair; Nitza Kahane; Chaya Kalcheim We have previously shown that overall growth of the myotome in the mediolateral direction occurs in a coherent and uniform pattern. We asked whether development of the dermomyotome and resultant dermis follow a similar pattern or are, alternatively...
Journal Articles
Journal: Development
Development (2003) 130 (15): 3415–3426.
Published: 1 August 2003
... in the mouse brain and is subjected to post-transcriptional regulation in neurons. Development 127 , 319 -331. Denetclaw, W. F. and Ordahl, C. P. ( 2000 ). The growth of the dermomyotome and formation of early myotome lineages in thoracolumbar somites of chicken embryos. Development 127 , 893 -905...
Journal Articles
Journal: Development
Development (2003) 130 (15): 3391–3402.
Published: 1 August 2003
...Loren D. Sacks; Gordon M. Cann; William Nikovits, Jr; Sandra Conlon; Nora R. Espinoza; Frank E. Stockdale The first skeletal muscle fibers to form in vertebrate embryos appear in the somitic myotome. PCR analysis and in situ hybridization with isoform-specific probes reveal differences...