... , G. and Buckingham , M. ( 1997 ). Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD . Cell 89 , 127 - 138 . 10.1016/S0092-8674(00)80189-0 Tozer , S. , Bonnin , M.-A. , Relaix , F. , Di Savino , S. , García...

...). We finally studied Fgf4 and Fgf6 , which are involved in myogenesis through their expression in the medial myotome ( Grass et al., 1996 ). We found that expression of Fgf4 and Fgf6 appeared highly reduced in mutant embryos ( Fig. 5 U-X). In summary, re-segmentation of the paraxial mesoderm...

...: The genesis of myogenic stem cells and their homing process during development are poorly known processes. We identified SIX homeoproteins as important regulators of this homing. Pax7 Six1 Six4 Homing Stem cells Myogenesis Muscle development in mouse takes place from embryonic day (E) 8...

... and misregulation of genes involved in muscle differentiation. Deletion of Myh3 during embryonic myogenesis leads to the depletion of the myogenic progenitor cell pool and an increase in the myoblast pool, whereas fetal myogenesis-specific deletion of Myh3 causes the depletion of both myogenic progenitor...

...Shuo Yang; Allison Weske; Yingqiu Du; Juliana M. Valera; Kenneth L. Jones; Aaron N. Johnson ABSTRACT Nascent myotubes undergo a dramatic morphological transformation during myogenesis, in which the myotubes elongate over several cell diameters and are directed to the correct muscle attachment sites...

...Shuang Cui; Liang Li; Ruth T. Yu; Michael Downes; Ronald M. Evans; Julie-Ann Hulin; Helen P. Makarenkova; Robyn Meech ABSTRACT Canonical Wnts promote myoblast differentiation; however, the role of β-catenin in adult myogenesis has been contentious, and its mechanism(s) unclear. Using CRISPR...

...: A fundamentally different mechanism is demonstrated for how Ras signaling governs cell fate specification in the Drosophila somatic versus visceral mesoderms, providing insight into how signaling specificity is achieved. Myogenesis Signal integration Founder cell Muscle progenitor Fusion competent...

.... A. and Tapscott , S. J. ( 2005 ). MyoD and the transcriptional control of myogenesis . Semin. Cell Dev. Biol.   16 , 585 - 595 . 10.1016/j.semcdb.2005.07.006 Braun , T. , Rudnicki , M. A. , Arnold , H.-H. and Jaenisch , R. ( 1992 ). Targeted inactivation of the muscle regulatory...

...Jessica Williams; Nathan G. Boin; Juliana M. Valera; Aaron N. Johnson For skeletal muscle to produce movement, individual myofibers must form stable contacts with tendon cells and then assemble sarcomeres. The myofiber precursor is the nascent myotube, and during myogenesis the myotube completes...

...Amar J. Majmundar; David S. M. Lee; Nicolas Skuli; Rickson C. Mesquita; Meeri N. Kim; Arjun G. Yodh; Michelle Nguyen-McCarty; Bo Li; M. Celeste Simon Deeper insight into the molecular pathways that orchestrate skeletal myogenesis should enhance our understanding of, and ability to treat, human...

... and intrinsic regulatory mechanisms. Satellite cell Muscle stem cell Myogenesis Quiescence Cell cycle regulation Asymmetric division Self-renewal Skeletal muscle Regeneration Aging Skeletal muscles are made up of numerous multinucleated myofibers that possess the contractile machinery...

.... Cell 23 , 469 - 481 . 10.1016/j.devcel.2012.07.014 Buas M. F. , Kadesch T. ( 2010 ). Regulation of skeletal myogenesis by Notch . Exp. Cell Res. 316 , 3028 - 3033 . 10.1016/j.yexcr.2010.05.002 Buas M. F. , Kabak S. , Kadesch T. ( 2010 ). The Notch...

... signaling suppressed both head and trunk myogenesis. Our findings, corroborated by mathematical modeling, suggest that ERK shuttling between the nucleus and the cytoplasm provides a switch-like transition between proliferation and differentiation of muscle progenitors. * Author for correspondence...

... Competing interests The authors declare no competing financial interests. 10 4 2013 20 9 2013 © 2013. Published by The Company of Biologists Ltd 2013 MyoD NFAT Myogenesis Calcineurin Skeletal muscle Myogenic regulatory factors Myosin heavy chain...

... about the molecular mechanisms that control the early stages of muscle morphogenesis. To explore this facet of myogenesis, we performed a genetic screen for regulators of somatic muscle morphology in Drosophila , and identified the putative RNA-binding protein (RBP) Hoi Polloi (Hoip). Hoip is expressed...

... function of the Myod -/- ;Igf2 +/- diaphragm, we analyzed its formation during the embryonic and fetal waves of myogenesis. No difference was observed at E13.5 between wt, Myod -/- and Igf2 +/- single mutants and DM embryos. However, at E15.5, lack of Myod leads to a thinner diaphragm...

...Boaz Gildor; Eyal D. Schejter; Ben-Zion Shilo A major aspect of indirect flight muscle formation during adult Drosophila myogenesis involves transition of a semi-differentiated and proliferating pool of myoblasts to a mature myoblast population, capable of fusing with nascent myotubes...

... and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104 New York, NY 10032, USA Competing interests statement The authors declare no competing financial interests 9 7 2012 © 2012. Tailup/Islet1 Collier/EBF Tinman/Nkx2.5 Myogenesis Temporal...

... development. TGFβ family members play important roles in regulating myogenesis, but the functional significance of Smad-dependent TGFβ signaling in regulating tongue skeletal muscle development remains unclear. In this study, we have investigated Smad4-mediated TGFβ signaling in the development of occipital...

... of myogenesis. These include using conditional mutant mice, using morpholinos in zebrafish and using hypomorphic mutants in Drosophila adult development. However, we show here that Mef2 is absolutely required for a diverse range of Drosophila adult muscle types. These include the dorso-longitudinal muscles...