1-19 of 19
Keywords: Myoblast fusion
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199928.
Published: 25 January 2022
... regionalized in central regions of foetal muscles. We also identified a similar regionalization for the gene encoding the NOTCH ligand JAG2 along with an absence of NOTCH activity in TMEM8C + fusion-competent myocytes. NOTCH function in myoblast fusion had not been addressed so far. We analysed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168351.
Published: 27 November 2018
... in a temporal- and spatial-specific manner. Here, we show that WNT/β-catenin signaling is crucial for myoblast fusion through regulation of the nephrin ( Nphs1 ) gene in the Myog-Cre -expressing myoblast population. Mice deficient for the β-catenin gene in Myog-Cre -expressing myoblasts ( Ctnnb1 F/F ;Myog-Cre...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2289–2301.
Published: 1 June 2014
... that the membrane phosphoinositide PI(4,5)P2 is a crucial regulator of F-actin dynamics during myoblast fusion. PI(4,5)P2 is locally enriched and colocalizes spatially and temporally with the F-actin focus that defines the fusion site. PI(4,5)P2 enrichment depends on receptor engagement but is upstream or parallel...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 4040–4050.
Published: 1 November 2012
... ( eyal.schejter@weizmann.ac.il ; benny.shilo@weizmann.ac.il ) Competing interests statement The authors declare no competing financial interests. 6 8 2012 © 2012. 2012 Notch Myoblast fusion Myogenesis Drosophila Multinucleated muscle cells are characteristic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1640–1650.
Published: 1 May 2012
... primordium, suggesting that CNC cells play an instructive role in guiding tongue muscle development. Moreover, ablation of Smad4 results in defects in myogenic terminal differentiation and myoblast fusion. Despite compromised muscle differentiation, tendon formation appears unaffected in the tongue of Myf5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2347–2357.
Published: 1 June 2011
...Priyankana Mukherjee; Boaz Gildor; Ben-Zion Shilo; K. VijayRaghavan; Eyal D. Schejter Myoblast fusion provides a fundamental, conserved mechanism for muscle fiber growth. We demonstrate here that the functional contribution of Wsp, the Drosophila homolog of the conserved actin nucleation-promoting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1551–1562.
Published: 15 April 2011
...Shruti Haralalka; Claude Shelton; Heather N. Cartwright; Erin Katzfey; Evan Janzen; Susan M. Abmayr Myoblast fusion is an intricate process that is initiated by cell recognition and adhesion, and culminates in cell membrane breakdown and formation of multinucleate syncytia. In the Drosophila embryo...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (7): 1159–1168.
Published: 1 April 2009
.... Previous studies have not resolved the role of Hibris(Hbs), a paralog of Sns, suggesting that it functions as a positive regulator of myoblast fusion and as a negative regulator that antagonizes the activity of Sns. The results herein resolve this issue, demonstrating that sns and hbs function redundantly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (5): 849–857.
Published: 1 March 2008
... distinct steps of the founder/myotube differentiation programme. Thus, in mib2 mutants, the early process of myoblast fusion is compromised, as FMs undergo a reduced number of rounds of fusion with FCMs. At later stages, with the onset of muscle contraction, many muscles degenerate, display aberrant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (24): 4357–4367.
Published: 15 December 2007
...Brian E. Richardson; Karen Beckett; Scott J. Nowak; Mary K. Baylies Myoblast fusion is crucial for formation and repair of skeletal muscle. Here we show that active remodeling of the actin cytoskeleton is essential for fusion in Drosophila . Using live imaging, we have identified a dynamic F-actin...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3145–3153.
Published: 1 September 2007
...Catherine A. Moore; Caroline A. Parkin; Yannick Bidet; Philip W. Ingham Myoblast fusion follows a defined sequence of events that is strikingly similar in vertebrates and invertebrates. Genetic analysis in Drosophila has identified many of the molecules that mediate the different steps...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (18): 4501–4509.
Published: 15 September 2004
...Roxane H. Schröter; Simone Lier; Anne Holz; Sven Bogdan; Christian Klämbt; Lothar Beck; Renate Renkawitz-Pohl Drosophila myoblast fusion proceeds in two steps. The first one gives rise to small syncytia, the muscle precursor cells, which then recruit further fusion competent myoblasts to reach...
Journal Articles
Journal: Development
Development (2004) 131 (4): 743–754.
Published: 15 February 2004
... cells Myoblast fusion Notch Delta lethal of scute jelly belly Alk RTK signalling The early events of mesoderm formation and specification have been studied extensively (reviewed by Anderson,1998 ), whereas the molecular mechanisms leading to different mesodermal cell types...
Journal Articles
Journal: Development
Development (2003) 130 (25): 6257–6272.
Published: 22 December 2003
... functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling. Development 128 , 4251 -4264. Bate, M. ( 1990 ). The embryonic development of larval muscles in Drosophila. Development 110 , 791 -804. Bate, M. ( 1993 ). The mesoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (15): 3437–3446.
Published: 1 August 2003
...+ current increases with voltage. This 10 mV depolarization raised the cytoplasmic free Ca 2+ concentration, and triggered a tenfold acceleration of myoblast fusion. Our results suggest that any mechanism able to modulate intracellular Ca 2+ concentration could affect the rate of myoblast fusion. Many...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5061–5073.
Published: 15 December 2001
...Annette Rau; Detlev Buttgereit; Anne Holz; Richard Fetter; Stephen K. Doberstein; Achim Paululat; Nicole Staudt; Jim Skeath; Alan M. Michelson; Renate Renkawitz-Pohl Mutations in the rolling pebbles ( rols ) gene result in severe defects in myoblast fusion. Muscle precursor cells are correctly...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4489–4500.
Published: 15 November 2001
.... *Author for correspondence (e-mail: hnguyen@aecom.yu.edu ) 24 8 2001 © 2001. 2001 Drosophila Lmd Muscle specification Mef2 Differentiation Myoblast fusion The formation of the larval body wall musculature in Drosophila results from the sequential implementation...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4229–4239.
Published: 1 November 2001
... lack of myoblast fusion ( Fig. 6 ) ( Ruiz-Gomez et al., 2000 ). The genomic interval removed by Df(1)w 67k30 extends from white to kirre . As yet, there is no single embryonic lethal locus known within this region. Hence, the Df(1)w 67k30 phenotype could be caused by the removal of two...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4251–4264.
Published: 1 November 2001
... tissues. In the somatic mesoderm, Hbs is restricted to fusion competent myoblasts and is regulated by Notch and Ras signaling pathways. Embryos that lack or overexpress hbs show a partial block of myoblast fusion, followed by abnormal muscle morphogenesis. Abnormalities in visceral mesoderm are also...