1-20 of 27
Keywords: Myc
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (9): dev197111.
Published: 28 April 2021
... cells failing to express NANOS2. Single-cell RNA sequencing revealed that embryonic day 15.5 NANOS2-deficient germ cells and embryonal carcinoma cells developed a transcriptional profile enriched for MYC signaling, NODAL signaling and primed pluripotency. Moreover, lineage-tracing experiments...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev190231.
Published: 11 June 2020
... silencing complex (RISC). The mechanism for growth inhibition does not, however, involve canonical roles as part of the RISC; rather, AGO1 controls cell and tissue growth by functioning as a direct transcriptional repressor of the master regulator of growth, Myc. AGO1 depletion in wing imaginal discs drives...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev173005.
Published: 2 August 2019
... Drosophila epithelium causes cells to enter the endocycle through the activation of Yorkie-dependent genes ( Myc and E2f1 ). Myc is even sufficient to induce the endocycle in the uninjured post-mitotic epithelium. As result, epithelial cells enter S phase but mitosis is blocked by inhibition of mitotic gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev161091.
Published: 30 July 2018
...Ioanna Mastromina; Laure Verrier; Joana Clara Silva; Kate G. Storey; J. Kim Dale ABSTRACT The Myc transcriptional regulators are implicated in a range of cellular functions, including proliferation, cell cycle progression, metabolism and pluripotency maintenance. Here, we investigated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev154898.
Published: 14 June 2018
... these control mechanisms in the hyaloid vessels, a temporary vascular network in the mammalian eye that requires a Wnt/β-catenin response for scheduled regression. We investigated whether the hyaloid Wnt response was linked to the oncogene Myc , and the cyclin-dependent kinase inhibitor CDKN1A (P21), both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4173–4182.
Published: 15 November 2017
... in the renewing and differentiating populations of the nephron progenitor cells. How β-catenin stimulated these two distinct programs was unclear. Here, we show that β-catenin cooperates with the transcription factor Myc to activate the progenitor renewal program. Although in multiple contexts Myc is a target...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 612–623.
Published: 15 February 2017
..., as a regulator of ISC proliferation that is upregulated in old ISCs. We show that Nipped-A is required for maintaining the proliferative capacity of ISCs during aging and in response to tissue-damaging or tumorigenic stimuli. Interestingly, Drosophila Myc cannot compensate for the effect of the loss of Nipped...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 623–634.
Published: 15 February 2016
... on opposed changes of junction tensions in the clone bulk and its boundary with neighboring wt tissue. More generally, either clone bulk or boundary junction tension is modulated by the activation of Yorkie, Myc and Ras, yielding similar contact reductions with wt cells. Together, our data highlight...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (16): 2792–2800.
Published: 15 August 2015
...-myc is required for proper morphogenesis of the cochlea and to control correct patterning of the organ of Corti. We show here that the Otx2 gene, a mammalian ortholog of the Drosophila orthodenticle homeobox gene, is a crucial target of N-myc during inner ear development. Otx2 expression is lost in N...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (5): 988–1000.
Published: 1 March 2014
... regulation of the Hippo pathway . Proc. Natl. Acad. Sci. USA 109 , 484 – 489 . Clavería C. , Giovinazzo G. , Sierra R. , Torres M. ( 2013 ). Myc-driven endogenous cell competition in the early mammalian embryo . Nature 500 , 39 – 44 . Cordero J. B. , Macagno...
Journal Articles
Journal: Development
Development (2013) 140 (23): 4776–4787.
Published: 1 December 2013
...Ling Li; Sarah Anderson; Julie Secombe; Robert N. Eisenman The essential and highly conserved role of Myc in organismal growth and development is dependent on the control of Myc protein abundance. It is now well established that Myc levels are in part regulated by ubiquitin-dependent proteasomal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (24): 4524–4535.
Published: 15 December 2012
... Drosophila midgut as a model system to investigate the molecular events that mediate intestinal hyperplasia following loss of Apc in the intestine. Our results indicate that the conserved Wnt target Myc and its binding partner Max are required for the initiation and maintenance of intestinal stem cell (ISC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 4051–4061.
Published: 1 November 2012
..., wing cells with increased Myc or with optimum ribosome function become supercompetitors that kill their wild-type neighbors (called losers) up to several cell diameters away. Here, we report that modulating STAT activity levels regulates competitor status. Cells lacking STAT become losers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 983–993.
Published: 15 March 2009
.... and Baylies, M. K. ( 2006 ). The development of the Drosophila larval body wall muscles. Int. Rev. Neurobiol. 75 , 55 -70. Bello Roufai, M., Li, H. and Sun, Z. ( 2007 ). Heart-specific inhibition of protooncogene c-myc attenuates cold-induced cardiac hypertrophy. Gene Ther. 14 , 1406 -1416...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (19): 3191–3196.
Published: 1 October 2008
...Hassan Nakhai; Jens T. Siveke; Lidia Mendoza-Torres; Roland M. Schmid Recent studies have shown that Wnt/β-catenin signaling is essential for development of the exocrine pancreas, but the role ofβ-catenin-dependent target genes such as Myc during pancreatic development is not well known. Here, we...
Journal Articles
Journal: Development
Development (2008) 135 (14): 2467–2477.
Published: 15 July 2008
...Chen He; Huiqing Hu; Rickmer Braren; Shun-Yin Fong; Andreas Trumpp; Timothy R. Carlson; Rong A. Wang The c-myc proto-oncogene, which is crucial for the progression of many human cancers, has been implicated in key cellular processes in diverse cell types, including endothelial cells that line...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (11): 1903–1911.
Published: 1 June 2008
...Claudia O. Rodrigues; Steve T. Nerlick; Elsie L. White; John L. Cleveland; Mary Lou King Myc -deficient mice fail to develop normal vascular networks and Myc -deficient embryonic stem cells fail to provoke a tumor angiogenic response when injected into immune compromised mice. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (8): 1583–1592.
Published: 15 April 2007
...Sara Ota; Zi-Qiang Zhou; Doug R. Keene; Paul Knoepfler; Peter J. Hurlin The developing limb serves as a paradigm for studying pattern formation and morphogenetic cell death. Here, we show that conditional deletion of N-Myc(Mycn) in the developing mouse limb leads to uniformly small skeletal...
Journal Articles
Journal: Development
Development (2005) 132 (8): 1831–1841.
Published: 15 April 2005
... this process have yet to be fully elucidated, recent work has suggested that Myc functions to prevent premature cell fate decisions in neural crest forming regions of the early ectoderm. Here, we show that the small HLH protein Id3 is a Myc target that plays an essential role in the formation and maintenance...
Journal Articles
Journal: Development
Development (2005) 132 (5): 1147–1160.
Published: 1 March 2005
.... This is particularly evident in the mammary gland, where both age at exposure to a carcinogenic stimulus and the timing of a first full-term pregnancy can markedly alter the risk of developing breast cancer. Analogous to this, the biological consequences of activating oncogenes, such as MYC, can be influenced...