... studies, and how clonal analysis can be applied to questions regarding multipotency. We also highlight how effective progenitor cell tracing, when combined with recently developed molecular and imaging tools, such as single-cell transcriptomics, single-molecule fluorescence in situ hybridization and high...

... after embryonic development and following their descendants. Recently, transplantation experiments involving permanently labeled cells revealed multipotent neural stem cells (NSCs) of embryonic origin in the medaka retina. To analyze whether NSC potency is affected by developmental progression...

... by The Company of Biologists Ltd 2013 FoxY Hedgehog Notch Coelomic pouch Left/right asymmetry Multipotency Strongylocentrotus purpuratus The ability of certain cells to resist differentiation is an important feature of animal development. Most notably, sexually reproducing...

... Multipotency Neural crest Stem cells Mouse Most melanocytes in vertebrates originate from the neural crest (NC). The neural crest cells (NCCs) delaminate from the neural tube, migrate through the periphery ( Dorris, 1938 ; Dorris, 1939 ; DuShane, 1935 ; Rawles, 1947 ; Twitty, 1936...

...Nathan A. Mundell; Patricia A. Labosky Neural crest (NC) progenitors generate a wide array of cell types, yet molecules controlling NC multipotency and self-renewal and factors mediating cell-intrinsic distinctions between multipotent versus fate-restricted progenitors are poorly understood. Our...

... for understanding these processes. The skeletal and connective tissues of the developing limb all derive from a population of multipotent progenitor cells located in its distal tip. During limb outgrowth,these progenitors segregate into a chondrogenic lineage, located in the center of the limb bud, and soft...

... was identical with a tunicate C-type lectin (TC14-2) reported previously. The other was a novel C-type lectin, referred to as TC14-3. In living animals, they appeared to be coupled. This complex of lectins, when applied in vitro to tunicate multipotent cells of epithelial origin, blocked cell proliferation...

.... In addition, however, P 0 and PMP22 are both expressed in a multipotent cell type isolated from early DRG. Like neural crest stem cells (NCSCs), this P 0 /PMP22-positive cell gives rise to glia, neurons and smooth-muscle-like cells in response to instructive extracellular cues. In cultures of differentiating...

... that neurons and glial cells of the peripheral nervous system can originate from the same progenitors as cartilage, one of the mesectodermal derivatives of the NC. Moreover, we obtained evidence that the migrating cephalic NC contains a few highly multipotent precursors that are common to neurons, glia...