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Development (2013) 140 (5): 1034–1044.
Published: 1 March 2013
... undifferentiated precursor cells located above the eye. Here, we demonstrate a role for Foxc1 in modulating the influence of Bmp signaling on the expression of Msx2 and the specification of these cells. Inactivation of Foxc1 results in a dramatic reduction in skull vault growth and causes an expansion of Msx2...
Includes: Supplementary data
Development (2008) 135 (21): 3577–3586.
Published: 1 November 2008
... cells (NCCs) that ultimately specifies cardiac NCC function for OFT development, but does not regulate NCC migration to the heart. We show that Pbx1 directly activates Pax3 , leading to repression of its target gene Msx2 in NCCs. Compound Msx2/Pbx1 -null embryos display significant rescue of cardiac...
Includes: Supplementary data
Development (2005) 132 (22): 4937–4950.
Published: 15 November 2005
...Mamoru Ishii; Jun Han; Hai-Yun Yen; Henry M. Sucov; Yang Chai; Robert E. Maxson, Jr The neural crest is a multipotent, migratory cell population that contributes to a variety of tissues and organs during vertebrate embryogenesis. Here, we focus on the function of Msx1 and Msx2 , homeobox genes...
Sean M. Brugger, Amy E. Merrill, Jesus Torres-Vazquez, Nancy Wu, Man-Chun Ting, Jane Y.-M. Cho, Sonia L. Dobias, Soyun E. Yi, Karen Lyons, Jeffery R. Bell, Kavita Arora, Rahul Warrior, Robert Maxson
Development (2004) 131 (20): 5153–5165.
Published: 15 October 2004
... transcriptional responses in different cell types. Here,we identify a BMP-responsive enhancer of Msx2 , an immediate early target of bone morphogenetic protein (BMP) signaling. We show that the BMP-responsive region of Msx2 consists of a core element, required generally for BMP-dependent expression, and ancillary...
Mamoru Ishii, Amy E. Merrill, Yan-Shun Chan, Inna Gitelman, David P. C. Rice, Henry M. Sucov, Robert E. Maxson, Jr
Development (2003) 130 (24): 6131–6142.
Published: 15 December 2003
... such anomaly is familial calvarial foramina, persistent unossified areas within the skull vault. Mutations in MSX2 and TWIST are known to cause calvarial foramina in humans. Little is known of the cellular and developmental processes underlying this defect. Neither is it known whether MSX2 and TWIST function...
Liang Ma, Jian Liu, Tobey Wu, Maksim Plikus, Ting-Xin Jiang, Qun Bi, Yi-Hsin Liu, Sven Müller-Röver, Heiko Peters, John P. Sundberg, Rob Maxson, Richard L. Maas, Cheng-Ming Chuong
Development (2003) 130 (2): 379–389.
Published: 15 January 2003
...Liang Ma; Jian Liu; Tobey Wu; Maksim Plikus; Ting-Xin Jiang; Qun Bi; Yi-Hsin Liu; Sven Müller-Röver; Heiko Peters; John P. Sundberg; Rob Maxson; Richard L. Maas; Cheng-Ming Chuong Msx2 -deficient mice exhibit progressive hair loss, starting at P14 and followed by successive cycles of wavelike...
Development (2002) 129 (19): 4647–4660.
Published: 1 October 2002
...) Upregulation of Msx1 expression in frontonasal mass (arrow) and maxillary prominence. (D) Expression of Msx2 encompasses one-third of the maxillary prominence (lower arrow) and the lateral third of the frontonasal mass (upper arrow). Normal expression domain of Msx2 in the maxilla is restricted...
Stanford J. Kwang, Sean M. Brugger, Arthur Lazik, Amy E. Merrill, Lan-Ying Wu, Yi-Hsin Liu, Mamoru Ishii, Frank O. Sangiorgi, Michael Rauchman, Henry M. Sucov, Richard L. Maas, Robert E. Maxson, Jr.
Development (2002) 129 (2): 527–538.
Published: 15 January 2002
... does not occur. Downstream genes through which Pax3 regulates cardiac neural crest development are unknown. Here, using a combination of genetic and molecular approaches, we show that the deficiency of cardiac neural crest development in the Splotch mutant is caused by upregulation of Msx2 , a homeobox...
Juan Antonio Montero, Yolanda Gañan, Domingo Macias, Joaquin Rodriguez-Leon, Juan Jose Sanz-Ezquerro, Ramon Merino, Jesus Chimal-Monroy, M. Angela Nieto, Juan M. Hurle
Development (2001) 128 (11): 2075–2084.
Published: 1 June 2001
... for a positive influence of FGFs on BMP gene expression, the physiological implication of FGFs in apoptosis appears to result from their requirement for the expression of genes of the apoptotic cascade. We have identified MSX2 and Snail as candidate genes associated with apoptosis the expression of which...
Denis Houzelstein, Gwenola Auda-Boucher, Yvonnick Chéraud, Thierry Rouaud, Isabelle Blanc, Shahragim Tajbakhsh, Margaret E. Buckingham, Josiane Fontaine-Pérus, Benoît Robert
Development (1999) 126 (12): 2689–2701.
Published: 15 June 1999
... dermomyotome, remains to be determined. Msx2 , the sister gene to Msx1 , has also been reported to inhibit myogenesis ( Takahashi et al., 1996 ). Transcripts of Msx2 were not detectable in somites by in situ hybridisation (data not shown), but it should be kept in mind that Msx1 transcripts were...
Development (1998) 125 (7): 1241–1251.
Published: 1 April 1998
... as craniosynostosis, presumably involves disturbance of these interactions. Mutations in the homeobox gene Msx2 as well as the FGF receptors cause human craniosynostosis syndromes. Our histological analysis of mouse calvarial development demonstrated morphological differences in the sagittal suture between embryonic...
Development (1995) 121 (4): 1065–1076.
Published: 1 April 1995
...Angela D. Reginelli; Yao-Qi Wang; David Sassoon; Ken Muneoka ABSTRACT We report that during mouse fetal development transcripts of Msx1 and Msx2 become progressively restricted to cells that will form more distal digit structures; the Msx2 expression domain is always more distal than Msx1...