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Keywords: Msx1
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Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (21): dev189175.
Published: 24 June 2020
.... Mutations in human MSX1 have been linked to orofacial clefting and we show here that Msx1 deficiency causes a growth defect of the medial nasal process (Mnp) in mouse embryos. Although this defect alone does not disrupt lip formation, Msx1 -deficient embryos develop a cleft lip when the mother...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2697–2702.
Published: 1 July 2013
.... Msx1 is among several transcription factors that are induced by epithelial Bmp4 and that, in turn, are necessary for the induction and maintenance of dental mesenchymal Bmp4 expression. Thus, Msx1 -/- teeth arrest at early bud stage and show loss of Bmp4 expression in the mesenchyme. Ectopic expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 423–432.
Published: 15 January 2013
...Shihai Jia; Jing Zhou; Yang Gao; Jin-A Baek; James F. Martin; Yu Lan; Rulang Jiang Previous studies have suggested that Bmp4 is a key Msx1-dependent mesenchymal odontogenic signal for driving tooth morphogenesis through the bud-to-cap transition. Whereas all tooth germs were arrested at the bud...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4225–4233.
Published: 15 December 2009
..., such as Msx1 -null mutants. Exogenous Fgf7 inhibits Shh signaling and reverses the cranial neural crest (CNC) cell proliferation rescue in the Msx1/Dlx5 double knockout palatal mesenchyme. Thus, Dlx5-regulated Fgf7 signaling inhibits the expression of Shh, which in turn controls the fate of CNC cells through...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (19): 3267–3278.
Published: 1 October 2009
... and the inhibition of preplacodal genes such as Six1 . In addition, we demonstrate that Gbx2 is upstream of the neural fold specifiers Pax3 and Msx1 . Our results place Gbx2 as the earliest factor in the NC genetic cascade being directly regulated by the inductive molecules, and support the notion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (11): 1939–1949.
Published: 1 June 2009
... -deficient cells is sufficient to induce surrounding wild-type epithelial and mesenchymal cells to participate in the formation of new teeth. Strikingly, Msx1 , which is necessary for endogenous tooth development, is dispensable for supernumerary tooth formation. In addition, we identify Fgf8 , a known tooth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (10): 1717–1726.
Published: 15 May 2009
... of neurons does not seem to result from a defect in NCC specification as all the usual markers, with the exception of Msx1 , are expressed in the dorsal caudal-most NT as early as E4/HH24. However, Bmp4-Wnt1 signaling, which triggers trunk NCC delamination, is impaired in this region due to persistence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3459–3470.
Published: 15 October 2008
... pathway that controls the differentiation of mesDA neurons shows that, in the absence of Otx2, the expression of Lmx1a and Msx1 , and the proneural genes Ngn2 and Mash1 is not activated in Sox2 + mesDA progenitors, which largely fail to differentiate into Nurr1 + mesDA precursors. Furthermore...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (22): 4937–4950.
Published: 15 November 2005
...Mamoru Ishii; Jun Han; Hai-Yun Yen; Henry M. Sucov; Yang Chai; Robert E. Maxson, Jr The neural crest is a multipotent, migratory cell population that contributes to a variety of tissues and organs during vertebrate embryogenesis. Here, we focus on the function of Msx1 and Msx2 , homeobox genes...
Journal Articles
Journal: Development
Development (2004) 131 (16): 3955–3966.
Published: 15 August 2004
... expression of Noggin in the embryonic area, and downregulation of Msx1 , a BMP4 target gene, with Msx1 expression being ultimately restricted to the most distal embryonic and extra-embryonic somatopleural mesoderm. Msx1 downregulation thus correlates with the formation of the pterylae, and its maintenance...
Journal Articles
Journal: Development
Development (2003) 130 (21): 5123–5132.
Published: 1 November 2003
... formation in the mouse and found that regenerative capability correlated with the expression domain of the Msx1 gene. Using the stage 11 (E14.5) digit, we now show that digit tip regeneration occurs in organ culture and that Msx1 , but not Msx2 , mutant mice display a regeneration defect. Associated...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4435–4442.
Published: 1 October 2002
...-Choudhury et al., 2001 ). Another possibility is that blocking BMP signaling by Noggin alters the cell type of the presumptive ciliary epithelium to neuronal cells that do not express BMPs. The expression pattern of homeobox gene Msx1 suggests a role in tissue patterning in the anterior region...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4647–4660.
Published: 1 October 2002
... radioactive probes as previously described ( Rowe et al., 1991 ). Chicken probes were generously provided by the following individuals: Fgf-8, J. C. Ispizúa Belmonte; Msx1, Msx2 , S. Wedden; Bmp2, Bmp4, P. Francis-West; Bmp7, B. Houston; Noggin, R. Johnson; Tbx2, Shh, C. Tabin. The basis...
Journal Articles
Journal: Development
Development (2002) 129 (17): 4135–4146.
Published: 1 September 2002
...Zunyi Zhang; Yiqiang Song; Xiang Zhao; Xiaoyun Zhang; Cesar Fermin; YiPing Chen Cleft palate, the most frequent congenital craniofacial birth defects in humans, arises from genetic or environmental perturbations in the multi-step process of palate development. Mutations in the MSX1 homeobox gene...
Journal Articles
Journal: Development
Development (2002) 129 (2): 527–538.
Published: 15 January 2002
... genetic data show that loss of Msx1 function does not rescue Splotch mutants to viability. Although we have not examined the hearts of Msx1-Pax3 double mutant embryos, the simplest explanation for this lack of rescue is that the Msx1 knockout fails to suppress the lethal cardiac defect of Splotch...