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Keywords: Motor neurons
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Journal Articles
Journal: Development
Development (2021) 148 (6): dev194514.
Published: 29 March 2021
... remains unclear. Here, we studied HOX clock pacing in human pluripotent stem cell-derived axial progenitors differentiating into diverse spinal cord motor neuron subtypes. We show that the progressive activation of caudal HOX genes is controlled by a dynamic increase in FGF signaling. Blocking the FGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev194415.
Published: 23 March 2021
...Matthew Wind; Antigoni Gogolou; Ichcha Manipur; Ilaria Granata; Larissa Butler; Peter W. Andrews; Ivana Barbaric; Ke Ning; Mario R. Guarracino; Marysia Placzek; Anestis Tsakiridis ABSTRACT The anteroposterior axial identity of motor neurons (MNs) determines their functionality and vulnerability...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (16): dev191023.
Published: 27 August 2020
...Kayt Scott; Rebecca O'Rourke; Austin Gillen; Bruce Appel ABSTRACT Spinal cord pMN progenitors sequentially produce motor neurons and oligodendrocyte precursor cells (OPCs). Some OPCs differentiate rapidly as myelinating oligodendrocytes, whereas others remain into adulthood. How pMN progenitors...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (17): dev174045.
Published: 6 September 2019
...Charlotte Chaimowicz; Pierre-Louis Ruffault; Cyril Chéret; Andrew Woehler; Niccolò Zampieri; Gilles Fortin; Alistair N. Garratt; Carmen Birchmeier ABSTRACT Feeding and breathing are essential motor functions and rely on the activity of hypoglossal and phrenic motor neurons that innervate the tongue...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (5): 830–836.
Published: 1 March 2017
... of organisation are largely unknown. We have previously shown that the assembly of motor neurons into nuclei depends on cadherin-mediated adhesion. Here, we demonstrate that the emergence of mature topography among motor nuclei involves a novel interplay between spontaneous activity, cadherin expression and gap...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4667–4680.
Published: 15 December 2014
... motor systems of invertebrates and vertebrates paved the way for understanding the transcriptional control of axon pathfinding. In mouse, chick, zebrafish, C. elegans and Drosophila , correlations between the transcription factors expressed in motor neurons and the target areas of their axons have...
Journal Articles
Journal: Development
Development (2014) 141 (9): 1875–1883.
Published: 1 May 2014
... of ventral neural tube segments, including motor neurons, in amphibian and avian embryos was observed to frequently result in the development of aneural limb muscle ( Hamburger, 1929 ; Honig et al., 1986 ; Swanson and Lewis, 1986 ; Taylor, 1944 ). Our own recent data provided a mechanistic basis for some...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (7): 1369–1383.
Published: 1 April 2007
... associated with dorsoventral patterning of the neural tube and acquisition of motor neuron progenitor domain identity. Concordant with its sites of expression and biochemistry, data are presented demonstrating that CYP1B1 is capable of eliciting responses that are consistent with the production of RA. Taken...
Includes: Supplementary data